SCHEMBL433511

SCHEMBL433511

C[C](C)Cc1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
IDO1 P14902 1/20 0.46
ALDH1A1 P00352 3/20 0.46
POLB P06746 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46
CTBP2 P56545 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.44
SLC6A2 P23975 2/20 0.43
SLC6A3 Q01959 2/20 0.43
TAAR1 Q96RJ0 1/20 0.43
HTR2A P28223 1/20 0.43
SLC6A4 P31645 1/20 0.43
HRH1 P35367 1/20 0.43
HTR2B P41595 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10558734 0.80 IDO1 (0.47) NPC1RAB9AL3MBTL1IDO1ALDH1A1
SCHEMBL9782634 0.80 NPC1 (0.46) NPC1RAB9AL3MBTL1IDO1ALDH1A1
SCHEMBL48823 0.80 L3MBTL1 (0.55) NPC1RAB9AL3MBTL1ALDH1A1POLB
SCHEMBL9342572 0.78 L3MBTL1 (0.44) NPC1RAB9AL3MBTL1IDO1ALDH1A1
Formaldehyde SCHEMBL2079424 0.77 L3MBTL1 (0.52) NPC1RAB9AL3MBTL1ALDH1A1POLB
SCHEMBL4226247 0.76 IDO1 (0.48) NPC1RAB9AL3MBTL1IDO1ALDH1A1
SCHEMBL6522029 0.76 CA2 (0.54) NPC1RAB9AALDH1A1KDM4EMEN1
SCHEMBL6616424 0.76 LPL (0.48) L3MBTL1IDO1ALDH1A1TAAR1MAPK1
SCHEMBL7946947 0.75 TAAR1 (0.50) IDO1ALDH1A1POLBKDM4EGAA
SCHEMBL7151264 0.75 NPC1 (0.50) NPC1RAB9AL3MBTL1ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113999223-A Flavone derivative containing thiazole, preparation method and application thereof 扬州大学 2022-02-01 CN claimed
EP-3363788-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2018-08-22 EP claimed
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2013-06-27 US claimed
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2012-08-23 US claimed
US-20240083839-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-03-14 US disclosed
US-11771695-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-10-03 US disclosed
US-11746091-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-09-05 US disclosed
EP-4225730-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS The Regents of the University of California (US) 2023-08-16 EP disclosed
US-20230165252-A1 ACTIVE COMPOUND COMBINATIONS BAYER AKTIENGESELLSCHAFT (DE) 2023-06-01 US disclosed
US-20230054449-A1 PYRIDAZINE (THIO)AMIDES AS FUNGICIDAL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2023-02-23 US disclosed
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2022-08-04 US disclosed
CN-109970708-B Cannabinoid receptor modulators 艾尼纳制药公司 2022-06-21 CN disclosed
EP-0362264-A1 NEW ARALKYL ESTERS AND PROCESSES FOR THEIR PREPARATION AKTIEBOLAGET ASTRA (SE) 1990-04-11 EP disclosed
WO-1988009327-A1 NEW ARALKYL ESTERS AND PROCESSES FOR THEIR PREPARATION AKTIEBOLAGET ASTRA (SE) 1988-12-01 WO disclosed
EP-0293351-A2 New aralkyl esters and processes for their preparation AKTIEBOLAGET ASTRA (SE) 1988-11-30 EP disclosed
US-4501746-A HERBICIDES; PLANT GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1985-02-26 US disclosed
EP-0035228-B1 TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1985-01-02 EP disclosed
US-4372953-A Tetrazole derivatives, and anti-ulcer composition containing the same OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1983-02-08 US disclosed
US-4098896-A FUNGICIDES CHEVRON RESEARCH COMPANY (US) 1978-07-04 US disclosed
US-4031087-A INSECTICIDES SHELL OIL COMPANY (US) 1977-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 NPC1 558/4885RAB9A 1558/4885L3MBTL1 4099/4885
US-20230165252-A1 ACTIVE COMPOUND COMBINATIONS CYP51A1, ERG28, BROX NPC1 2222/4885RAB9A 2628/4885L3MBTL1 3879/4885
US-11746091-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 NPC1 558/4885RAB9A 1558/4885L3MBTL1 4099/4885
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS CNR2, CNR1, OPRL1 NPC1 1184/4885RAB9A 1386/4885L3MBTL1 4838/4885
US-20230054449-A1 PYRIDAZINE (THIO)AMIDES AS FUNGICIDAL COMPOUNDS PNPO, TPMT, BLVRB NPC1 4090/4885RAB9A 2990/4885L3MBTL1 1804/4885
US-11771695-B2 Cannabinoid receptor modulators CNR2, CNR1, OPRL1 NPC1 1184/4885RAB9A 1386/4885L3MBTL1 4838/4885
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 NPC1 558/4885RAB9A 1558/4885L3MBTL1 4099/4885
US-20240083839-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS PRMT8, SIRT1, PRMT3 NPC1 704/4885RAB9A 924/4885L3MBTL1 1480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.