Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435915 | 0.88 | P2RX7 (0.60) | POLBKMT2ATP53LMNAP2RX7 | |
| Hydrochloric Acid SCHEMBL433923 | 0.86 | HSD11B1 (0.49) | KMT2ATP53LMNAP2RX7MAPT | |
| SCHEMBL433860 | 0.84 | P2RX7 (0.55) | TP53LMNAP2RX7CYP2D6 | |
| SCHEMBL433922 | 0.82 | SMN1; SMN2 (0.53) | KMT2ATP53LMNAP2RX7ALDH1A1 | |
| SCHEMBL432970 | 0.82 | CYP1A2 (0.44) | KMT2ATP53LMNAP2RX7MAPT | |
| Hydrochloric Acid SCHEMBL433170 | 0.82 | SMN1; SMN2 (0.52) | KMT2ATP53LMNAP2RX7ALDH1A1 | |
| SCHEMBL435467 | 0.80 | ALDH1A1 (0.44) | POLBKMT2ATP53P2RX7MAPT | |
| SCHEMBL434266 | 0.79 | MAPT (0.53) | POLBKMT2ATP53LMNAP2RX7 | |
| SCHEMBL434790 | 0.78 | OPRM1 (0.47) | POLBKMT2AP2RX7ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL435636 | 0.78 | HTT (0.48) | KMT2AP2RX7MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |