SCHEMBL4360178

SCHEMBL4360178

O=C(c1cc([N+](=O)[O-])cc(S(=O)(=O)[O-])c1)c1cc([N+](=O)[O-])cc(S(=O)(=O)[O-])c1.[Na+].[Na+]

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 4/20 0.43
CA1 known ✓ P00915 3/20 0.43
CA12 known ✓ O43570 1/20 0.43
ALOX5 known ✓ P09917 2/20 0.37
CYP3A4 P08684 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
GAA P10253 2/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
SRD5A2 P31213 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
TP53 P04637 1/20 0.39
LMNA P02545 1/20 0.39
ALDH1A1 P00352 3/20 0.38
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4360179 0.84 CYP3A4 (0.47) CYP3A4SMN1; SMN2CA2CA1CA12
SCHEMBL28540842 0.83 CYP19A1 (0.52) CYP3A4SMN1; SMN2CA2CA1CA12
SCHEMBL11221351 0.83 HTT (0.48) CA2CA1CA12CA9CA14
SCHEMBL4360176 0.83 CYP3A4 (0.46) CYP3A4SMN1; SMN2CA2CA1CA12
Lithium Ion SCHEMBL28617436 0.79 CYP19A1 (0.52) CYP3A4SMN1; SMN2CA2CA1CA12
SCHEMBL1566658 0.79 CYP3A4 (0.68) CYP3A4SMN1; SMN2GAAKMT2ASRD5A2
SCHEMBL14421292 0.75 CES2 (0.55) CA2CA1CA12CA9CA14
SCHEMBL2820718 0.75 ACP1 (0.43) CYP3A4CA2CA1CA12CA9
SCHEMBL8439600 0.75 CA2 (0.49) CYP3A4SMN1; SMN2CA2CA1CA12
SCHEMBL28533048 0.72 KMT2A (0.40) CA2CA1CA12CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1457511-B1 CROSSLINKABLE AROMATIC RESINS HAVING PROTONIC ACID GROUPS AND ION CONDUCTIVE POLYMER MEMBRANES BINDERS AND FUEL CELLS MADE BY USING THE SAME MITSUI CHEMICALS INC (JP) 2009-07-15 EP disclosed
EP-1457511-A1 CROSSLINKABLE AROMATIC RESINS HAVING PROTONIC ACID GROUPS AND ION CONDUCTIVE POLYMER MEMBRANES BINDERS AND FUEL CELLS MADE BY USING THE SAME Mitsui Chemicals, Inc. (JP) 2004-09-15 EP disclosed