Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.77 |
| ▸ | CA1 known ✓ | P00915 | 17/20 | 0.75 |
| ▸ | CA2 known ✓ | P00918 | 17/20 | 0.75 |
| ▸ | CA12 known ✓ | O43570 | 13/20 | 0.68 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 13/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL4362953 | 0.94 | CA1 (0.75) | THRBCA1CA2CA12CA9 | |
| SCHEMBL9019655 | 0.91 | CA1 (0.81) | THRBCA1CA2CA12CA9 | |
| SCHEMBL8830317 | 0.91 | CA1 (0.81) | THRBCA1CA2CA12CA9 | |
| SCHEMBL5308757 | 0.87 | THRB (1.00) | THRBCA1CA2CA12CA9 | |
| SCHEMBL137550 | 0.87 | THRB (1.00) | THRBCA1CA2CA12CA9 | |
| Water SCHEMBL28117119 | 0.84 | THRB (0.93) | THRBCA1CA2CA12CA9 | |
| SCHEMBL9067544 | 0.84 | THRB (0.93) | THRBCA1CA2CA12CA9 | |
| SCHEMBL665710 | 0.84 | — | — | |
| SCHEMBL10968142 | 0.83 | MAPK1 (0.56) | THRBCA1CA2CA12CA9 | |
| SCHEMBL11117831 | 0.80 | THRB (0.87) | THRBCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930318-B1 | Process for producing diphenyl sulfone compound | NIPPON SODA CO (JP) | 2017-03-08 | — | — | EP | disclosed |
| EP-1273570-B1 | PROCESS FOR PRODUCING DIPHENYL SULFONE COMPOUND | NIPPON SODA CO (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-7619120-B2 | Processes for the preparation of diphenylsulfone compounds | NIPPON SODA CO., LTD. (JP) | 2009-11-17 | — | — | US | disclosed |
| EP-1930318-A2 | Process for producing diphenyl sulfone compound | Nippon Soda Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
| US-20050065377-A1 | Processes for the preparation of diphenylsulfone compounds | NIPPON SODA CO., LTD | 2005-03-24 | — | — | US | disclosed |
| US-6831201-B2 | Aqueous solution containing dihydroxydiphenyl sulfone monoether compound is adjusted pH to a preset value, extracted with an organic solvent and separated to an organic and an aqueous layers, and that water or water adjusted to a fixed pH | NIPPON SODA CO., LTD. (JP) | 2004-12-14 | — | — | US | disclosed |
| US-20030092941-A1 | Process for producing diphenyl sulfone compound | NIPPON SODA CO., LTD. (JP) | 2003-05-15 | — | — | US | disclosed |
| EP-1273570-A1 | PROCESS FOR PRODUCING DIPHENYL SULFONE COMPOUND | NIPPON SODA CO., LTD. (JP) | 2003-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092941-A1 | Process for producing diphenyl sulfone compound | ASH2L, AP2S1, HACL2 | THRB 3161/4885CA1 1213/4885CA2 201/4885 |
| US-20050065377-A1 | Processes for the preparation of diphenylsulfone compounds | AP2S1, ASH2L, SRMS | THRB 3040/4885CA1 2033/4885CA2 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.