SCHEMBL437166

SCHEMBL437166

CC(C)=C1C2CCC1c1c(N)cccc12

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 0.32
SLC6A4 P31645 3/20 0.32
SLC6A3 Q01959 3/20 0.32
CYP3A4 P08684 2/20 0.32
RGS12 O14924 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
ALOX12 P18054 1/20 0.32
NFKB1 P19838 1/20 0.32
HTR2A P28223 1/20 0.32
MAPK1 P28482 1/20 0.32
ADRA1A P35348 1/20 0.32
PTGS2 P35354 1/20 0.32
HRH1 P35367 1/20 0.32
OPRM1 P35372 1/20 0.32
GNAI1 P63096 1/20 0.32
KCNH2 Q12809 1/20 0.32
TSHR P16473 1/20 0.30
PIK3CA P42336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14701145 0.87 SLC6A2 (0.31) SLC6A2SLC6A4SLC6A3CYP3A4RGS12
SCHEMBL9267056 0.87 SLC6A2 (0.31) SLC6A2SLC6A4SLC6A3CYP3A4RGS12
SCHEMBL6981992 0.84 ADRA2A (0.31) ADRA2A
SCHEMBL12459370 0.83 SLC6A2 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4RGS12
SCHEMBL30367219 0.83 ADRA2A (0.30) ADRA2A
SCHEMBL30626982 0.83 ADRA2A (0.30) ADRA2A
SCHEMBL2297652 0.83 ADRA2A (0.30) ADRA2A
SCHEMBL10098727 0.76
SCHEMBL13227173 0.73 ADRA2A (0.42) MAPK1TSHRADRA2A
SCHEMBL12533480 0.73 ADRA2A (0.32) SLC6A2SLC6A4SLC6A3CYP3A4RGS12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11647749-B2 Fungicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2023-05-16 US disclosed
US-20170202220-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-07-20 US disclosed
US-9642365-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2017-05-09 US disclosed
EP-2347655-B1 SYNERGISTIC FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2016-12-14 EP disclosed
US-20160192655-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2016-07-07 US disclosed
US-9314022-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2016-04-19 US disclosed
US-9115043-B2 Process for the preparation of benzonorbornenes SYNGENTA CROP PROTECTION, LLC (US) 2015-08-25 US disclosed
US-20150141712-A1 PROCESS FOR THE PREPARATION OF BENZONORBORNENES SYNGENTA PARTICIPATIONS AG (CH) 2015-05-21 US disclosed
US-8680337-B2 Process for the production of amides Sungenta Limited (GB) 2014-03-25 US disclosed
US-20140024532-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2014-01-23 US disclosed
US-7956194-B2 Microbiocidal (E.G. fungicidal) 1,2,3-triazole derivatives SYNGENTA CROP PROTECTION, INC. (US) 2011-06-07 US disclosed
EP-2258690-A1 Tricyclic amines as intermediates in the synthesis of fungicidal carboxamide derivatives Syngenta Participations AG (CH) 2010-12-08 EP disclosed
US-20100216640-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2010-08-26 US disclosed
US-20090306166-A1 Method of Controlling Phytopathogenic Diseases on Turfgrass SYNGENTA CROP PROTECTION, INC. (US) 2009-12-10 US disclosed
US-20090306166-A1 Method of Controlling Phytopathogenic Diseases on Turfgrass SYNGENTA CROP PROTECTION, INC. (US) 2009-12-10 US disclosed
US-20090163569-A1 PROCESS FOR THE PRODUCTION OF AMIDES SYNGENTA CROP PROTECTION, INC. (US) 2009-06-25 US disclosed
US-20070265267-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2007-11-15 US disclosed
US-20070265267-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2007-11-15 US disclosed
US-20070244121-A1 Synergistic Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070244121-A1 Synergistic Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11647749-B2 Fungicidal compositions BROX, RER1, BLVRB SLC6A2 4332/4885SLC6A4 4309/4885SLC6A3 3416/4885
US-20150141712-A1 PROCESS FOR THE PREPARATION OF BENZONORBORNENES CCL5, CXCR2, CXCR3 SLC6A2 4583/4885SLC6A4 3895/4885SLC6A3 1609/4885
US-20140024532-A1 FUNGICIDAL COMPOSITIONS BROX, RER1, BLVRB SLC6A2 4332/4885SLC6A4 4309/4885SLC6A3 3416/4885
US-20160192655-A1 FUNGICIDAL COMPOSITIONS BROX, RER1, BLVRB SLC6A2 4332/4885SLC6A4 4309/4885SLC6A3 3416/4885
US-20100216640-A1 FUNGICIDAL COMPOSITIONS BROX, RER1, BLVRB SLC6A2 4249/4885SLC6A4 4329/4885SLC6A3 3334/4885
US-20170202220-A1 FUNGICIDAL COMPOSITIONS BROX, RER1, BLVRB SLC6A2 4332/4885SLC6A4 4309/4885SLC6A3 3416/4885
US-20070265267-A1 FUNGICIDAL COMPOSITIONS CRY1, ERG28, DDT SLC6A2 2581/4885SLC6A4 2862/4885SLC6A3 2189/4885
US-20070244121-A1 Synergistic Fungicidal Compositions DDT, CRY1, HCN1 SLC6A2 1645/4885SLC6A4 1582/4885SLC6A3 795/4885
US-20090163569-A1 PROCESS FOR THE PRODUCTION OF AMIDES C5, CFH, C9 SLC6A2 3219/4885SLC6A4 2896/4885SLC6A3 2694/4885
US-20090306166-A1 Method of Controlling Phytopathogenic Diseases on Turfgrass MAPT, TBCA, TTL SLC6A2 3523/4885SLC6A4 3429/4885SLC6A3 4527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.