Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442244 | 0.86 | ACHE (0.43) | ACHEBCHEGRIN1GRIN2APARP1 | |
| SCHEMBL437952 | 0.81 | ACHE (0.45) | ACHE | |
| SCHEMBL12210442 | 0.81 | ACHE (0.49) | ACHEBCHEGRIN1GRIN2ACHEK1 | |
| SCHEMBL25544293 | 0.79 | CHEK1 (0.41) | CHEK1PARP1PIM1RPS6KA3HTR1A | |
| SCHEMBL442268 | 0.79 | ACHE (0.46) | ACHEBCHEGRIN1GRIN2ACHEK1 | |
| SCHEMBL439004 | 0.79 | ACHE (0.43) | ACHE | |
| SCHEMBL437945 | 0.78 | ACHE (0.47) | ACHEHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL437126 | 0.78 | NOS3 (0.38) | KDM4EALDH1A1GAATP53CYP3A4 | |
| SCHEMBL437195 | 0.76 | UHRF1 (0.35) | PSMB5NOS3NOS2 | |
| SCHEMBL437067 | 0.75 | MAOB (0.46) | PARP1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |