Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398103 | 1.00 | POLB (0.44) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL20148150 | 1.00 | POLB (0.44) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| Hydrochloric Acid SCHEMBL28114698 | 0.98 | POLB (0.43) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL19779833 | 0.85 | ACHE (0.43) | POLBSMN1; SMN2LMNANFE2L2ALDH1A1 | |
| SCHEMBL19900300 | 0.85 | MAOB (0.43) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL5771963 | 0.85 | NFE2L2 (0.35) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL5771965 | 0.85 | NFE2L2 (0.35) | POLBSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL5302952 | 0.85 | CYP1A2 (0.54) | SMN1; SMN2LMNARAB9AALDH1A1MEN1 | |
| SCHEMBL19900073 | 0.85 | ACHE (0.43) | POLBSMN1; SMN2LMNANFE2L2ALDH1A1 | |
| SCHEMBL2164318 | 0.85 | CYP1A2 (0.54) | SMN1; SMN2LMNARAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116912-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | TERNS PHARMACEUTICALS, INC. | 2024-04-11 | — | — | US | disclosed |
| EP-4271377-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | Terns Pharmaceuticals, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-116887827-A | Compounds and methods for modulating FXR | 拓臻制药公司 | 2023-10-13 | — | — | CN | disclosed |
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | ARDELYX, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | ARDELYX, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | ARDELYX, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| CN-110845486-B | Triazole alcohol derivative and preparation method and application thereof | 中国人民解放军第二军医大学 | 2023-03-21 | — | — | CN | disclosed |
| WO-2022147448-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | TERNS PHARMACEUTICALS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| WO-2022147448-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | TERNS PHARMACEUTICALS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| US-20210300927-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | ARDELYX, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-20040077675-A1 | Compounds and methods for inhibiting MRP1 | BONJOUKLIAN ROSANNE (US) | 2004-04-22 | — | — | US | disclosed |
| US-6686469-B2 | TREATMENT FOR PLANT PROPAGATION MATERIAL FOR PARASITICIDES | NOVARTIS ANIMAL HEALTH US, INC. | 2004-02-03 | — | — | US | disclosed |
| US-6670373-B1 | Inhibiting resistant neoplasms where the resistance is conferred by multidrug resistance protein; N-3,4,5-trimethoxyphenyl-3-(3-azidomethyl-isoxazolo(4,5-c) -1,2-dihydro-6-chloro-quinolin-2-on-1-yl)phenylacetamide | ELI LILLY AND COMPANY | 2003-12-30 | — | — | US | disclosed |
| US-20030195226-A1 | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors | SIT SING-YUEN (US) | 2003-10-16 | — | — | US | disclosed |
| WO-2003065989-A2 | (OXIME)CARBAMOYL FATTY ACID AMIDE HYDROLASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-08-14 | — | — | WO | disclosed |
| US-20030004347-A1 | Pesticidal pyrimidine-derivatives | NOVARTIS ANIMAL HEALTH US, INC. | 2003-01-02 | — | — | US | disclosed |
| EP-1224189-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1175407-A1 | PESTICIDAL PYRIMIDINE-DERIVATIVES | Syngenta Participations AG (CH) | 2002-01-30 | — | — | EP | disclosed |
| WO-2001027116-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
| WO-2000066565-A1 | PESTICIDAL PYRIMIDINE-DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718619-B2 | Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators | FXR1, FXR2, NR1H4 | POLB 3462/4885SMN1; SMN2 4791/4885LMNA 4510/4885 |
| US-20210300927-A1 | ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS | FXR1, FXR2, NR1H4 | POLB 3462/4885SMN1; SMN2 4791/4885LMNA 4510/4885 |
| US-20040077675-A1 | Compounds and methods for inhibiting MRP1 | ABCC1, ABCB1, ABCB11 | POLB 979/4885SMN1; SMN2 4456/4885LMNA 2127/4885 |
| US-20030195226-A1 | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors | FAAH, FAAH2, NCEH1 | POLB 2973/4885SMN1; SMN2 1362/4885LMNA 4276/4885 |
| US-20030004347-A1 | Pesticidal pyrimidine-derivatives | CTRC, HCN1, DDT | POLB 3555/4885SMN1; SMN2 1456/4885LMNA 2765/4885 |
| US-20240116912-A1 | COMPOUNDS AND METHODS FOR MODULATING FXR | NR1H4, FXR1, FXR2 | POLB 3424/4885SMN1; SMN2 4878/4885LMNA 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.