SCHEMBL4404031

SCHEMBL4404031

Cn1c(C(F)(F)F)cc(=O)n(-c2cc(C(=O)Cl)c(Cl)cc2F)c1=O

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MAPT P10636 1/20 0.31
TSHR P16473 1/20 0.31
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29449329 1.00 POLB (0.32) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL2976620 0.91 NOTUM (0.34) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL9423295 0.91 POLB (0.32) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL9497444 0.89 POLB (0.32) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL31362249 0.89 LMNA (0.34) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL27559360 0.87 GAA (0.36) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL30704867 0.87 GAA (0.36) POLBAPEX1HPGDSMN1; SMN2MAPT
SCHEMBL9497450 0.87 GRM4 (0.30)
SCHEMBL10698384 0.86 HPGD (0.32) HPGDSMN1; SMN2
SCHEMBL10695876 0.86 BCAT1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4289824-A1 URACIL COMPOUND CONTAINING CARBOXYLATE FRAGMENT AND PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION, AND USE Jiangsu Flag Chemical Industry Co., Ltd. (CN) 2023-12-13 EP disclosed
US-8362026-B2 Crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methyl-ethyl)amino]sulfonyl]benzamide BASF SE (DE) 2013-01-29 US disclosed
US-8362026-B2 Crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methyl-ethyl)amino]sulfonyl]benzamide BASF SE (DE) 2013-01-29 US disclosed
US-8357695-B2 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BASF SE (DE) 2013-01-22 US disclosed
US-8357695-B2 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BASF SE (DE) 2013-01-22 US disclosed
EP-2079714-B1 HYDRATES OF 2-CHLORO-5-Ý3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORO-METHYL)-1-(2H)-PYRIMIDINYL¨-4-FLUORO-N-ÝÝMETHYL-(1-METHYLETHYL)-AMINO¨SULPHONYL¨BENZAMIDE BASF SE (DE) 2012-09-26 EP disclosed
EP-2081914-B1 CRYSTALLINE FORM OF 2-CHLORO-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUOROMETHYL)-1-(2H)-PYRIMIDINYL]-4-FLUORO-N-[[METHYL-(1-METHYL-ETHYL)AMINO]SULPHONYL]BENZAMIDE BASF SE (DE) 2011-03-02 EP disclosed
US-20100105562-A1 Crystalline Form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BASF Agro B.V. (NL) 2010-04-29 US disclosed
US-20100105562-A1 Crystalline Form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BASF Agro B.V. (NL) 2010-04-29 US disclosed
US-20100035905-A1 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BASF Agro B.V. (CH) 2010-02-11 US disclosed
CN-100509771-C Method for the production of sulphamic acid halogenides BASF AG (DE) 2009-07-08 CN disclosed
WO-2008043835-A2 CRYSTALLINE FORM OF 2-CHLORO-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUOROMETHYL)-1-(2H)-PYRIMIDINYL]-4-FLUORO-N-[[METHYL-(1-METHYL-ETHYL)AMINO]SULPHONYL]BENZAMIDE BASF SE (DE) 2008-04-17 WO disclosed
WO-2008043836-A1 HYDRATES OF 2-CHLORO-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORO-METHYL)-1-(2H)-PYRIMIDINYL]-4-FLUORO-N-[[METHYL-(1-METHYLETHYL)-AMINO]SULPHONYL]BENZAMIDE BASF SE (DE) 2008-04-17 WO disclosed
US-7232926-B2 Method for the production of sulphamic acid halogenides BASF AKTIENGESELLSCHAFT (DE) 2007-06-19 US disclosed
CN-1681793-A Novel benzohydrazide derivatives as herbicides and desiccant compositions contaning them ISHIHARA SANGYO KAISHA (JP) 2005-10-12 CN disclosed
US-20050221990-A1 Novel benzohydrazide derivatives as herbicides and desiccant compositions contaning them ISHIHARA SANGYO KAISHA, LTD. (JP) 2005-10-06 US disclosed
CN-1653043-A Preparation of sulfamoyl halides BASF AG (DE) 2005-08-10 CN disclosed
US-20050159622-A1 Method for the production of sulphamic acid halogenides BASF AKTIENGESELLSCHAFT (DE) 2005-07-21 US disclosed
US-6770597-B2 Benzohydrazide derivatives as herbicides and desiccant compositions containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 2004-08-03 US disclosed
US-20040018942-A1 Novel benzohydrazide derivatives as herbicides and desiccant compositions containing them ISHIHARA SANGYO KAISHA, LTD. 2004-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050221990-A1 Novel benzohydrazide derivatives as herbicides and desiccant compositions contaning them DDT, ZYX, CBX4 POLB 2240/4885APEX1 4581/4885HPGD 3065/4885
US-20100105562-A1 Crystalline Form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide BROX, NT5C, DCUN1D5 POLB 3291/4885APEX1 2717/4885HPGD 4063/4885
US-20040018942-A1 Novel benzohydrazide derivatives as herbicides and desiccant compositions containing them DDT, HDHD5, DDX41 POLB 2901/4885APEX1 4114/4885HPGD 3335/4885
US-20050159622-A1 Method for the production of sulphamic acid halogenides AS3MT, ARSA, SRM POLB 1692/4885APEX1 934/4885HPGD 4004/4885
US-20100035905-A1 Hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide DHX15, DHX35, BROX POLB 1622/4885APEX1 1503/4885HPGD 2068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.