Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406835 | 0.90 | CHRM3 (0.40) | CHRM3MCHR1DRD4DRD2WNT1 | |
| SCHEMBL4396992 | 0.89 | KMT2A (0.41) | CHRM3MCHR1DRD4DYRK1AKCNH2 | |
| SCHEMBL4396337 | 0.88 | HTR7 (0.43) | — | |
| SCHEMBL4396457 | 0.88 | HRH3 (0.42) | HRH3DRD2KCNH2 | |
| SCHEMBL4410349 | 0.88 | HRH3 (0.42) | HRH3DRD2KCNH2 | |
| SCHEMBL4396410 | 0.88 | L3MBTL1 (0.40) | MCHR1HRH3WNT1DYRK1A | |
| SCHEMBL913892 | 0.87 | DRD4 (0.43) | CHRM3MCHR1HRH3DRD4HTR2A | |
| SCHEMBL4401571 | 0.86 | HPGDS (0.39) | WNT1DYRK1A | |
| SCHEMBL4394199 | 0.85 | CHRM3 (0.41) | CHRM3WNT1DYRK1A | |
| SCHEMBL4405570 | 0.83 | TLR7 (0.43) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |