Water

Water

SCHEMBL4418331

O.O=S(=O)(O)CC(O)CCl.[NaH]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 1/20 0.42
SLC22A6 Q4U2R8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23793924 0.97 CA1 (0.43) CA1CA2CA9SLC22A6
SCHEMBL272977 0.97 CA1 (0.43) CA1CA2CA9SLC22A6
SCHEMBL20582199 0.95
SCHEMBL151184 0.95
SCHEMBL27498737 0.92 CA1 (0.43) CA1CA2CA9SLC22A6
Hydrogen Sulfide SCHEMBL28099567 0.92 CA1 (0.43) CA1CA2CA9SLC22A6
Ammonia Solution, Strong SCHEMBL27517712 0.92 CA1 (0.43) CA1CA2CA9SLC22A6
SCHEMBL29761917 0.92 CA1 (0.43) CA1CA2CA9SLC22A6
SCHEMBL28040116 0.92 CA1 (0.43) CA1CA2CA9SLC22A6
Ether SCHEMBL9859454 0.81 CA1 (0.34) CA1CA2CA9SLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12528775-B2 Oxygenated and amino- or ammonium-containing phosphonic acid derivatives and their medical use GRI BIO, INC. (US) 2026-01-20 US disclosed
EP-3597634-B1 OXYGENATED AMMONIUM-CONTAINING SULFONIC ACIDS AND THEIR MEDICAL USE GRI BIO INC (US) 2025-02-26 EP disclosed
US-20230265052-A1 OXYGENATED AND AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE ALTIUM GROWTH FUND, LP 2023-08-24 US disclosed
US-11453642-B2 Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use GRI BIO, INC. (US) 2022-09-27 US disclosed
US-20210114979-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE ALTIUM GROWTH FUND, LP 2021-04-22 US disclosed
US-10815195-B2 Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use GRI BIO, INC. (US) 2020-10-27 US disclosed
EP-2809648-B1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID DERIVATIVES AND THEIR MEDICAL USE GRI BIO INC (US) 2019-04-03 EP disclosed
US-20170369430-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE ALTIUM GROWTH FUND, LP 2017-12-28 US disclosed
US-9751834-B2 Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use GRI BIO, INC. (US) 2017-09-05 US disclosed
US-20150284320-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE GLYCOREGIMMUNE, INC. (US) 2015-10-08 US disclosed
EP-2809648-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE Jado Technologies GmbH (DE) 2014-12-10 EP disclosed
WO-2012160186-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE JADO TECHNOLOGIES GMBH (DE) 2012-11-29 WO disclosed
EP-1109779-B8 NOVEL MERCAPTANS AND DISULFIDES BIONUMERIK PHARMACEUTICALS INC (US) 2009-05-27 EP disclosed
EP-1109779-B1 NOVEL MERCAPTANS AND DISULFIDES BIONUMERIK PHARMACEUTICALS INC (US) 2009-03-11 EP disclosed
EP-1109779-A4 NOVEL MERCAPTANS AND DISULFIDES BIONUMERIK PHARMACEUTICALS INC (US) 2003-04-16 EP disclosed
EP-1109779-A1 NOVEL MERCAPTANS AND DISULFIDES BIONUMERIK PHARMACEUTICALS, INC. (US) 2001-06-27 EP disclosed
US-6160167-A Mercaptans and disulfides BIONUMERIK PHARMACEUTICALS, INC. (US) 2000-12-12 US disclosed
WO-2000012469-A1 NOVEL MERCAPTANS AND DISULFIDES BIONUMERIK PHARMACEUTICALS, INC. (US) 2000-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11453642-B2 Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use AADAT, ASS1, IL4I1 CA1 46/4885CA2 29/4885CA9 52/4885
US-12528775-B2 Oxygenated and amino- or ammonium-containing phosphonic acid derivatives and their medical use OXGR1, OXER1, MALT1 CA1 98/4885CA2 20/4885CA9 152/4885
US-20210114979-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE AADAT, ASS1, IL4I1 CA1 46/4885CA2 29/4885CA9 52/4885
US-20230265052-A1 OXYGENATED AND AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE ASS1, AADAT, ASPH CA1 46/4885CA2 24/4885CA9 43/4885
US-20170369430-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE AADAT, ASS1, ALAD CA1 113/4885CA2 89/4885CA9 95/4885
US-20150284320-A1 OXYGENATED AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE AADAT, ASS1, IL4I1 CA1 44/4885CA2 28/4885CA9 52/4885
US-10815195-B2 Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use ASS1, AADAT, ASPH CA1 48/4885CA2 20/4885CA9 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.