Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9999688 | 0.93 | ENPP2 (0.54) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL11576495 | 0.91 | TSHR (0.52) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL13971231 | 0.87 | CALM1 (0.75) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| SCHEMBL7613502 | 0.87 | CALM1 (0.75) | CALM1IDH1PRSS1PRSS2PRSS3 | |
| SCHEMBL123838 | 0.84 | TSHR (0.61) | TSHRPRSS1PRSS2PRSS3ENPP2 | |
| Hydrochloric Acid SCHEMBL2068170 | 0.84 | IDH1 (0.44) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL12782166 | 0.83 | IDH1 (0.42) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL8713097 | 0.83 | ENPP2 (0.42) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL12002732 | 0.83 | IDH1 (0.42) | TSHRCALM1IDH1PRSS1PRSS2 | |
| SCHEMBL27299642 | 0.83 | SLC5A2 (0.49) | TSHRIDH1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629155-B2 | Small molecule antagonist compound TAC5 series having toll-like receptor 3/7/8/9 inhibitory function | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2023-04-18 | — | — | US | disclosed |
| US-20210214372-A1 | SMALL MOLECULE ANTAGONIST COMPOUND TAC5 SERIES HAVING TOLL-LIKE RECEPTOR 3/7/8/9 INHIBITORY FUNCTION | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2021-07-15 | — | — | US | disclosed |
| US-20210214372-A1 | SMALL MOLECULE ANTAGONIST COMPOUND TAC5 SERIES HAVING TOLL-LIKE RECEPTOR 3/7/8/9 INHIBITORY FUNCTION | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2021-07-15 | — | — | US | disclosed |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-24 | — | — | US | disclosed |
| US-9856278-B2 | Lysophosphatidylserine derivative | THE UNIVERSITY OF TOKYO (JP) | 2018-01-02 | — | — | US | disclosed |
| US-9828338-B2 | Carbamate derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-28 | — | — | US | disclosed |
| US-20170210767-A1 | LYSOPHOSPHATIDYLSERINE DERIVATIVE | THE UNIVERSITY OF TOKYO (JP) | 2017-07-27 | — | — | US | disclosed |
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20160068482-A1 | CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-03-10 | — | — | US | disclosed |
| US-4622337-A | INSECTICIDES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-11-11 | — | — | US | disclosed |
| US-4464391-A | Pesticides | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-08-07 | — | — | US | disclosed |
| EP-0095636-A1 | N-substituted imino esters, process for their preparation and their use in pesticides | BAYER AG (DE) | 1983-12-07 | — | — | EP | disclosed |
| US-4411912-A | Insecticidal isovaleric acid esters | ZOECON CORPORATION (US) | 1983-10-25 | — | — | US | disclosed |
| US-4327109-A | INSECTICIDES | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1982-04-27 | — | — | US | disclosed |
| US-4243819-A | Substituted amino acids | ZOECON CORPORATION (US) | 1981-01-06 | — | — | US | disclosed |
| US-4229469-A | Insecticidal alkadienylcyclopropanecarboxylates | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1980-10-21 | — | — | US | disclosed |
| US-4113968-A | FROM A 1-HALO-3-ALKENE-2-OL | KURARAY CO., LTD. (JP) | 1978-09-12 | — | — | US | disclosed |
| US-3998868-A | INSECTICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-12-21 | — | — | US | disclosed |
| US-3954814-A | INSECTICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068482-A1 | CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS | NAAA, FAAH, FAAH2 | TSHR 4069/4885CALM1 2771/4885IDH1 2951/4885 |
| US-20190023701-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | EPX, MPO, SERPINB1 | TSHR 2587/4885CALM1 3804/4885IDH1 1331/4885 |
| US-20170210767-A1 | LYSOPHOSPHATIDYLSERINE DERIVATIVE | LPAR3, LPAR1, LPAR4 | TSHR 526/4885CALM1 2248/4885IDH1 4182/4885 |
| US-11629155-B2 | Small molecule antagonist compound TAC5 series having toll-like receptor 3/7/8/9 inhibitory function | TLR5, TLR8, TLR9 | TSHR 617/4885CALM1 2892/4885IDH1 4492/4885 |
| US-10407422-B2 | Triazolopyridine inhibitors of myeloperoxidase | EPX, MPO, SERPINB1 | TSHR 2587/4885CALM1 3804/4885IDH1 1331/4885 |
| US-20210214372-A1 | SMALL MOLECULE ANTAGONIST COMPOUND TAC5 SERIES HAVING TOLL-LIKE RECEPTOR 3/7/8/9 INHIBITORY FUNCTION | TLR5, TLR8, TLR9 | TSHR 617/4885CALM1 2892/4885IDH1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.