Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11221338 | 0.78 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL8629680 | 0.77 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL8630238 | 0.77 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL8629170 | 0.77 | CASP3 (0.46) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL5267951 | 0.74 | ALOX15 (0.47) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL15392970 | 0.73 | NOTUM (0.36) | NPC1RAB9ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL3613332 | 0.73 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL5945934 | 0.73 | NOTUM (0.54) | NOTUML3MBTL1HSD11B1C1R | |
| SCHEMBL352664 | 0.71 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDNOTUM | |
| SCHEMBL11324245 | 0.70 | L3MBTL1 (0.55) | NPC1RAB9AALDH1A1KDM4ECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239853-A1 | New compounds | BIOVITRUM AB (SE) | 2005-10-27 | — | — | US | claimed |
| WO-2005075471-A2 | THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | BIOVITRUM AB (SE) | 2005-08-18 | — | — | WO | claimed |
| CN-110846675-B | Synthetic method of 2- (5-aryl-1, 3, 4-oxadiazole-2-yl) aniline compound | 阜阳师范大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-110846675-A | Synthetic method of 2- (5-aryl-1, 3, 4-oxadiazole-2-yl) aniline compound | 阜阳师范大学 | 2020-02-28 | — | — | CN | disclosed |
| US-20090136472-A1 | Use of thiazole derivatives and analogues in disorders caused by free fatty acids | BETAGENON AB (SE) | 2009-05-28 | — | — | US | disclosed |
| WO-2008090356-A1 | THIAZOLIDINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND DISORDERS CAUSED BY EXCESS ADIPOSITY | BETAGENON AB (SE) | 2008-07-31 | — | — | WO | disclosed |
| EP-1906956-A2 | USE OF THIAZOLE DERIVATIVES AND ANALOGUES IN DISORDERS CAUSED BY FREE FATTY ACIDS | Betagenon AB (SE) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007010281-A2 | USE OF THIAZOLE DERIVATIVES AND ANALOGUES IN DISORDERS CAUSED BY FREE FATTY ACIDS | BETAGENON AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| US-20050239853-A1 | New compounds | BIOVITRUM AB (SE) | 2005-10-27 | — | — | US | disclosed |
| WO-2005075471-A2 | THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | BIOVITRUM AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239853-A1 | New compounds | HSD11B1, CYP11B1, HSD3B1 | NPC1 277/4885RAB9A 2649/4885SMN1; SMN2 3733/4885 |
| US-20090136472-A1 | Use of thiazole derivatives and analogues in disorders caused by free fatty acids | FFAR2, FFAR1, FFAR4 | NPC1 778/4885RAB9A 3790/4885SMN1; SMN2 2257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.