SCHEMBL448144

SCHEMBL448144

Cc1cc(C)c(OBOc2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 3/20 0.38
ACHE P22303 1/20 0.35
ALDH1A1 P00352 3/20 0.32
MAPT P10636 2/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
GLA P06280 1/20 0.31
TSHR P16473 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5424156 0.79 SCN4A (0.41) RAPGEF4MAPTKDM4ELMNAKMT2A
SCHEMBL3437814 0.79 RAPGEF4 (0.35) RAPGEF4ACHEALDH1A1MAPTKDM4E
SCHEMBL4342022 0.77 ALDH1A1 (0.46) ACHEALDH1A1GAAKMT2ACYP1A2
SCHEMBL11420240 0.73 RAPGEF4 (0.43) RAPGEF4ACHEALDH1A1MAPTKDM4E
SCHEMBL242786 0.73 RAPGEF4 (0.43) RAPGEF4ACHEALDH1A1MAPTKDM4E
SCHEMBL4520516 0.72
Phosphine SCHEMBL22634061 0.71 RAPGEF4 (0.41) RAPGEF4ACHEALDH1A1MAPTKDM4E
SCHEMBL129762 0.71 ACHE (0.57) RAPGEF4ACHEALDH1A1MAPTLMNA
SCHEMBL10798387 0.71 RAPGEF4 (0.41) RAPGEF4ACHEALDH1A1MAPTKDM4E
SCHEMBL2122566 0.70 KMT2A (0.31) ACHEALDH1A1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9362122-B2 Process for contact doping YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2016-06-07 US claimed
WO-2012137211-A1 PROCESS FOR CONTACT DOPING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2012-10-11 WO claimed
WO-1995005081-A1 BIOCIDAL COMPOSITIONS CONTAINING ORGANOBORON COMPOUNDS U.S. BORAX INC. (US) 1995-02-23 WO claimed
US-12565508-B2 Group III and lanthanide bis-phenyl-phenoxy metal-ligand complexes DOW GLOBAL TECHNOLOGIES LLC (US) 2026-03-03 US disclosed
US-12497414-B2 Group III and Lanthanide bis-phenyl-phenoxy metal-ligand complexes DOW GLOBAL TECHNOLOGIES LLC (US) 2025-12-16 US disclosed
EP-4606806-A1 TRANSITION METAL COMPOUND AND CATALYST COMPOSITION COMPRISING THE SAME LG CHEM, LTD. (KR) 2025-08-27 EP disclosed
EP-4097151-B1 GROUP III AND LANTHANIDE BIS-PHENYL-PHENOXY METAL-LIGAND COMPLEXES DOW GLOBAL TECHNOLOGIES LLC (US) 2025-08-06 EP disclosed
EP-3990503-B1 OLEFIN POLYMERIZATION CATALYSTS BEARING A THIAZOLE OR IMIDAZOLE DOW GLOBAL TECHNOLOGIES LLC (US) 2025-07-23 EP disclosed
US-12286502-B2 Olefin polymerization catalysts bearing a thiazole or imidazole DOW GLOBAL TECHNOLOGIES LLC (US) 2025-04-29 US disclosed
EP-4298135-B1 BIS-PHENOXY-ETHER LIGANDS FOR GROUP IV POLYOLEFIN CATALYSIS DOW GLOBAL TECHNOLOGIES LLC (US) 2025-04-16 EP disclosed
US-20250002519-A1 NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME UNIV YALE (US) 2025-01-02 US disclosed
US-20030139402-A1 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated byVLA-4 KONRADI ANDREI W (US) 2003-07-24 US disclosed
US-20030125324-A1 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 KONRADI ANDREI W (US) 2003-07-03 US disclosed
US-6492372-B1 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 ELAN PHARMACEUTICALS, INC. 2002-12-10 US disclosed
EP-1144388-A1 ACYL DERIVATIVES WHICH TREAT VLA-4 RELATED DISORDERS Elan Pharmaceuticals, Inc. (US) 2001-10-17 EP disclosed
WO-2000043372-A1 ACYL DERIVATIVES WHICH TREAT VLA-4 RELATED DISORDERS ELAN PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed
WO-1995005081-A1 BIOCIDAL COMPOSITIONS CONTAINING ORGANOBORON COMPOUNDS U.S. BORAX INC. (US) 1995-02-23 WO disclosed
EP-0199260-B1 BORONIC ACID ADDUCTS OF TECHNETIUM-99M DIOXIME COMPLEXES E.R. Squibb & Sons, Inc. (US) 1989-12-06 EP disclosed
US-4705849-A Boronic acid adducts of technetium-99m dioxime complexes E. R. SQUIBB & SONS, INC. (US) 1987-11-10 US disclosed
EP-0199260-A2 Boronic acid adducts of technetium-99M dioxime complexes E.R. Squibb & Sons, Inc. (US) 1986-10-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139402-A1 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated byVLA-4 VCAM1, ICAM1, ITGB4 RAPGEF4 1132/4885ACHE 747/4885ALDH1A1 386/4885
US-12565508-B2 Group III and lanthanide bis-phenyl-phenoxy metal-ligand complexes SCO2, CBR3, SOD1 RAPGEF4 3046/4885ACHE 3347/4885ALDH1A1 4089/4885
US-20250002519-A1 NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME TIMCC, YAP1, TET2 RAPGEF4 927/4885ACHE 814/4885ALDH1A1 1759/4885
US-20030125324-A1 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 VCAM1, ICAM1, ITGB4 RAPGEF4 1462/4885ACHE 652/4885ALDH1A1 260/4885
US-12497414-B2 Group III and Lanthanide bis-phenyl-phenoxy metal-ligand complexes SSB, SOD1, LGALS3 RAPGEF4 1324/4885ACHE 1607/4885ALDH1A1 3746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.