Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494579 | 0.82 | ALDH1A1 (0.43) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL4492513 | 0.82 | ALDH1A1 (0.43) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL4504869 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL4488093 | 0.78 | VDR (0.40) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL4559832 | 0.78 | TP53 (0.46) | ALDH1A1LMNANPSR1MAPTPKM | |
| SCHEMBL4488101 | 0.78 | BRD4 (0.43) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL4492331 | 0.77 | LMNA (0.42) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL4485664 | 0.77 | KDM4E (0.40) | ALDH1A1LMNANPSR1MAPTMEN1 | |
| SCHEMBL4482567 | 0.76 | PLA2G2A (0.43) | ALDH1A1KMT2AKDM4ETDP1 | |
| SCHEMBL4490040 | 0.76 | GFER (0.47) | ALDH1A1NPSR1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |