Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485204 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL4494579 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL4488093 | 0.76 | VDR (0.40) | ALDH1A1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL4504869 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL4559832 | 0.75 | TP53 (0.46) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL4490747 | 0.75 | PGR (0.43) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL4492331 | 0.75 | LMNA (0.42) | ALDH1A1MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL4485664 | 0.75 | KDM4E (0.40) | ALDH1A1KDM4EMEN1KMT2ATSHR | |
| SCHEMBL4490040 | 0.73 | GFER (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL4482567 | 0.73 | PLA2G2A (0.43) | ALDH1A1KDM4EKMT2AHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |