Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.57 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477472 | 0.89 | PGR (0.48) | ARCFTRLMNACYP19A1KMT2A | |
| SCHEMBL4494579 | 0.88 | ALDH1A1 (0.43) | ARLMNAKMT2AMEN1POLB | |
| SCHEMBL4490040 | 0.83 | GFER (0.47) | PLA2G2AKDM4EMAPTHTTALDH1A1 | |
| SCHEMBL4485664 | 0.82 | KDM4E (0.40) | LMNAKMT2AMEN1POLBKDM4E | |
| SCHEMBL4491745 | 0.82 | AR (0.43) | ARPOLBKDM4EMAPTALDH1A1 | |
| SCHEMBL4492336 | 0.82 | AR (0.47) | ARLMNAKMT2AMEN1POLB | |
| SCHEMBL4559832 | 0.78 | TP53 (0.46) | LMNAKMT2AMEN1MAPTHTT | |
| SCHEMBL4490747 | 0.78 | PGR (0.43) | LMNAKMT2AMEN1PLA2G2AKDM4E | |
| SCHEMBL4488093 | 0.77 | VDR (0.40) | LMNAKMT2AMEN1POLBMAPT | |
| SCHEMBL4504869 | 0.77 | ALDH1A1 (0.42) | LMNAKMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |