SCHEMBL4547564

SCHEMBL4547564

CC(C)(C)NCC(=O)C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.37
VDR P11473 2/20 0.34
DPP8 Q6V1X1 1/20 0.33
DPP9 Q86TI2 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8056854 0.84 RECQL (0.33) DPP4VDR
SCHEMBL12467629 0.77 DPP4 (0.34) DPP4DPP8DPP9
SCHEMBL10072496 0.77 VDR (0.39) DPP4VDRCA12CA1CA2
SCHEMBL41886 0.77
SCHEMBL1717828 0.77 HMGCR (0.41) DPP4DPP8DPP9ALDH1A1LMNA
SCHEMBL10774381 0.77 VDR (0.36) VDRCA12CA1CA2CA9
SCHEMBL13404866 0.75 POLB (0.37) CA12CA2CA9KMT2AALDH1A1
SCHEMBL21938427 0.75 MEN1 (0.37) DPP4DPP8DPP9KMT2AALDH1A1
SCHEMBL22384807 0.75 VDR (0.34) VDR
SCHEMBL759391 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239863-A1 GIP RECEPTOR AGONIST AND USE THEREOF HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) 2024-07-18 US disclosed
US-20240226225-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-07-11 US disclosed
US-20240226313-A1 CEACAM5 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF SEAGEN INC. 2024-07-11 US disclosed
US-20240226225-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-07-11 US disclosed
US-20240209053-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-06-27 US disclosed
US-20240209053-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-06-27 US disclosed
US-12018057-B2 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases JANSSEN BIOTECH, INC. (US) 2024-06-25 US disclosed
US-20240066131-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-02-29 US disclosed
US-20240066131-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-02-29 US disclosed
US-20240018189-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-01-18 US disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 US disclosed
US-20120107237-A1 ARG-GLY-ASP-CONJUGATED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME STC.UNM (US) 2012-05-03 US disclosed
WO-2011156003-A2 PEPTOID AND SYNTHETIC OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME NEW YORK UNIVERSITY (US) 2011-12-15 WO disclosed
US-20110033380-A1 COMPOUNDS AND METHODS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME STC UNM (MX) 2011-02-10 US disclosed
US-20100317057-A1 SEMI-RECOMBINANT PREPARATION OF GLP-1 ANALOGUES NOVO NORDISK A/S (DK) 2010-12-16 US disclosed
US-20100285144-A1 POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-11-11 US disclosed
US-20100247668-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-09-30 US disclosed
US-20100247669-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-09-30 US disclosed
US-20080287347-A1 Novel Lipopeptides as Antibacterial Agents CUBIST PHARMACEUTICALS, INC. 2008-11-20 US disclosed
US-7408025-B2 Lipopeptides as antibacterial agents CUBIST PHARMACEUTICALS, INC. (US) 2008-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240226313-A1 CEACAM5 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF EPCAM, TOP2A, SPAG5 DPP4 2123/4885VDR 4762/4885DPP8 1841/4885
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 DPP4 1529/4885VDR 3622/4885DPP8 1418/4885
US-20240018189-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, VIP, HDGF DPP4 841/4885VDR 831/4885DPP8 863/4885
US-20080287347-A1 Novel Lipopeptides as Antibacterial Agents CLPTM1, NGLY1, VIP DPP4 437/4885VDR 2879/4885DPP8 461/4885
US-20100247669-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 DPP4 4583/4885VDR 4572/4885DPP8 4247/4885
US-20110033380-A1 COMPOUNDS AND METHODS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME MC1R, MC3R, MC4R DPP4 738/4885VDR 397/4885DPP8 1537/4885
US-20120107237-A1 ARG-GLY-ASP-CONJUGATED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME MC1R, MC3R, MC4R DPP4 432/4885VDR 454/4885DPP8 698/4885
US-20240239863-A1 GIP RECEPTOR AGONIST AND USE THEREOF GIPR, GLP1R, GPR119 DPP4 67/4885VDR 421/4885DPP8 102/4885
US-12018057-B2 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases IL23R, IL1RN, VIP DPP4 375/4885VDR 251/4885DPP8 252/4885
US-20240066131-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, VIP, HDGF DPP4 841/4885VDR 831/4885DPP8 863/4885
US-20100247668-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 DPP4 4583/4885VDR 4572/4885DPP8 4247/4885
US-20100285144-A1 POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE EPOR, TTPA, PDS5A DPP4 4711/4885VDR 4496/4885DPP8 4315/4885
US-20240226225-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, SLC40A1, FTH1 DPP4 2638/4885VDR 1424/4885DPP8 2365/4885
US-20240209053-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, SLC40A1, FTH1 DPP4 2165/4885VDR 1372/4885DPP8 1928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.