Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.47 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 7/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL1094530 | 0.97 | FABP3 (0.53) | FABP3EPHX2FAAHGMNNUSP2 | |
| SCHEMBL25301056 | 0.91 | CA2 (0.56) | EPHX2CA2CA1MAPTRECQL | |
| SCHEMBL2123674 | 0.91 | CA2 (0.56) | EPHX2CA2CA1MAPTRECQL | |
| SCHEMBL3018922 | 0.91 | CA2 (0.56) | EPHX2CA2CA1MAPTRECQL | |
| SCHEMBL8076961 | 0.87 | FAAH (0.50) | FABP3EPHX2FAAHGMNNUSP2 | |
| SCHEMBL31402375 | 0.84 | EPHX2 (0.48) | FABP3EPHX2FAAH | |
| SCHEMBL1534918 | 0.84 | FAAH (0.51) | FABP3EPHX2FAAHGMNNUSP2 | |
| Sulfuric Acid SCHEMBL325122 | 0.83 | CA2 (0.67) | FABP3EPHX2CA2CA1FAAH | |
| SCHEMBL2231242 | 0.83 | EPHX2 (0.44) | FABP3EPHX2FAAH | |
| Sulfuric Acid SCHEMBL2231589 | 0.82 | CA2 (0.70) | FABP3EPHX2CA2CA1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040137056-A1 | Wet granulation formulation for bisphosphonic acids | KATDARE ASHOK V (US) | 2004-07-15 | — | — | US | claimed |
| US-6692764-B2 | TREATMENT AND PREVENTION OF DISEASES INVOLVING BONE RESORPTION, ESPECIALLY OSTEOPOROSIS, PAGET'S DISEASE, MALIGNANT HYPERCALCEMIA, AND METASTATIC BONE DISEASE; BINDER-FREE TABLETS | MERCK & CO., INC. | 2004-02-17 | — | — | US | claimed |
| US-20030032628-A1 | Wet granulation formulation for bisphosphonic acids | MERCK & CO., INC. | 2003-02-13 | — | — | US | claimed |
| EP-0756484-B1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | claimed |
| US-20020137727-A1 | Wet granulation formulation for bisphosphonic acids | MERCK & CO., INC. | 2002-09-26 | — | — | US | claimed |
| US-20010007863-A1 | Wet granulation formulation for bisphosphonic acids | MERCK & CO., INC. | 2001-07-12 | — | — | US | claimed |
| EP-0756484-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO. INC. (US) | 1997-02-05 | — | — | EP | claimed |
| WO-1995029679-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1995-11-09 | — | — | WO | claimed |
| EP-3206671-B1 | PROCESS FOR PREPARING A DIRECTLY COMPRESSIBLE ERYTHRITOL AND USES THEREOF | CARGILL INC (US) | 2024-06-12 | — | — | EP | disclosed |
| EP-3146537-B1 | AMPHIPHILIC MAGNETIC NANOPARTICLES AND AGGREGATES TO REMOVE HYDROCARBONS AND METAL IONS AND SYNTHESIS THEREOF | MILANO POLITECNICO (IT) | 2020-04-08 | — | — | EP | disclosed |
| US-10463620-B2 | Process for preparing a directly compressible erythritol and uses thereof | CARGILL, INCORPORATED (US) | 2019-11-05 | — | — | US | disclosed |
| US-10418159-B2 | Amphiphilic magnetic nanoparticles and aggregates to remove hydrocarbons and metal ions and synthesis thereof | POLITECNICO DI MILANO (IT) | 2019-09-17 | — | — | US | disclosed |
| EP-2691415-B1 | METHOD FOR PRODUCING SOLID FORMULATIONS COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS | ABLYNX NV (BE) | 2018-07-11 | — | — | EP | disclosed |
| US-20170304206-A1 | PROCESS FOR PREPARING A DIRECTLY COMPRESSIBLE ERYTHRITOL AND USES THEREOF | CARGILL, INCORPORATED | 2017-10-26 | — | — | US | disclosed |
| EP-0857020-A4 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | MERCK & CO INC (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0857020-A1 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | Merck & Co., Inc. (US) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015191-A1 | WET GRANULATION FORMULATION OF A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |
| EP-0756484-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO. INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| WO-1996012476-A1 | WET GRANULATION FORMULATION FOR A PIPERAZINYLCAMPHORSULFONYL OXYTOCIN RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | disclosed |
| WO-1995029679-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1995-11-09 | — | — | WO | disclosed |