Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLTC | Q00610 | 8/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.33 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL31670338 | 1.00 | CLTC (0.46) | CLTCFTOP2RY12CDK2P2RY2 | |
| SCHEMBL1615000 | 0.78 | ALDH1A1 (0.39) | CLTC | |
| Potassium Ion SCHEMBL5415633 | 0.75 | CLTC (0.45) | CLTCFTOMEN1POLBCCR6 | |
| Lithium Ion SCHEMBL25250540 | 0.72 | CLTC (0.42) | CLTCFTOP2RY12MEN1POLB | |
| Lithium Ion SCHEMBL29354256 | 0.72 | CLTC (0.42) | CLTCFTOP2RY12MEN1POLB | |
| Lithium Ion SCHEMBL94590 | 0.71 | CLTC (0.42) | CLTCFTOP2RY12MEN1POLB | |
| Lithium Ion SCHEMBL95351 | 0.69 | CLTC (0.44) | CLTCMEN1KMT2A | |
| Lithium Ion SCHEMBL29875131 | 0.69 | CLTC (0.44) | CLTCMEN1KMT2A | |
| SCHEMBL30608350 | 0.67 | TYMS (0.44) | CLTCP2RY4 | |
| Potassium Ion SCHEMBL3736126 | 0.65 | TYMS (0.53) | CLTCMEN1POLBKMT2APKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471118-B1 | Colorant precursor compounds containing one polyoxyalkylene group | XEROX CORP (US) | 2008-06-18 | — | — | EP | disclosed |
| EP-1216830-B1 | Negative photo- or heat- sensitive lithographic printing plate | FUJI PHOTO FILM CO LTD (JP) | 2007-03-07 | — | — | EP | disclosed |
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-6794116-B2 | ADDITION POLYMER; PHOTOPOLYMERIZATION | FUJI PHOTO FILM CO., LTD. (JP) | 2004-09-21 | — | — | US | disclosed |
| US-20020142249-A1 | Addition polymer; photopolymerization | FUJIFILM CORPORATION (JP) | 2002-10-03 | — | — | US | disclosed |
| EP-1216830-A2 | Negative photo- or heat- sensitive lithographic printing plate | Fuji Photo Film Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |