Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLTC | Q00610 | 15/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL29354256 | 0.77 | CLTC (0.42) | CLTCFTOMEN1POLBCCR6 | |
| Lithium Ion SCHEMBL25250540 | 0.77 | CLTC (0.42) | CLTCFTOMEN1POLBCCR6 | |
| Lithium Ion SCHEMBL94590 | 0.76 | CLTC (0.42) | CLTCFTOMEN1POLBCCR6 | |
| Potassium Ion SCHEMBL31670338 | 0.75 | CLTC (0.46) | CLTCFTOMEN1POLBCCR6 | |
| Potassium Ion SCHEMBL4636440 | 0.75 | CLTC (0.46) | CLTCFTOMEN1POLBCCR6 | |
| Lithium Ion SCHEMBL29875131 | 0.67 | CLTC (0.44) | CLTCMEN1KMT2A | |
| Lithium Ion SCHEMBL95351 | 0.67 | CLTC (0.44) | CLTCMEN1KMT2A | |
| SCHEMBL16097930 | 0.62 | ALDH1A1 (0.33) | CLTC | |
| SCHEMBL8032702 | 0.61 | ALDH1A1 (0.33) | CLTC | |
| SCHEMBL21946061 | 0.61 | CLTC (0.36) | CLTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093474-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2007-04-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093474-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | CLTC 369/4885FTO 4015/4885MEN1 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.