Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | PPM1D | O15297 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28138572 | 0.78 | DAO (0.48) | DAOPPM1DKDM4CEPHX2 | |
| SCHEMBL27975645 | 0.76 | DAO (0.45) | DAOPPM1DKDM4C | |
| SCHEMBL3557808 | 0.74 | ALDH1A1 (0.36) | RIPK1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28133767 | 0.70 | GPR84 (0.38) | DAOPPM1D | |
| SCHEMBL27712207 | 0.70 | MCL1 (0.41) | DAOPPM1DKDM4CSPHK1 | |
| SCHEMBL9336982 | 0.68 | RIPK1 (0.63) | RIPK1EPHX2 | |
| SCHEMBL28139210 | 0.66 | CYP2C19 (0.43) | ALDH1A1 | |
| SCHEMBL16880582 | 0.66 | CYP11B2 (0.42) | RIPK1CYP11B2 | |
| SCHEMBL14569581 | 0.65 | ROCK2 (0.44) | RIPK1CYP11B2 | |
| SCHEMBL14569489 | 0.65 | EPHX2 (0.47) | RIPK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963312-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007061930-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |