Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694455 | 0.81 | CHRNB2 (0.44) | SMN1; SMN2 | |
| SCHEMBL4692415 | 0.80 | RAB9A (0.49) | HRH4DRD2DRD3POLBSMN1; SMN2 | |
| SCHEMBL4692755 | 0.80 | ALDH1A1 (0.45) | DRD2DRD3 | |
| SCHEMBL4691846 | 0.79 | DPP4 (0.46) | HRH4HRH3DRD2DRD3CA12 | |
| SCHEMBL4689903 | 0.79 | P2RX7 (0.41) | POLBCA12CA1CA2CA7 | |
| SCHEMBL4691802 | 0.77 | CCR5 (0.48) | SMN1; SMN2 | |
| SCHEMBL4691301 | 0.77 | HCRTR1 (0.44) | — | |
| SCHEMBL4691928 | 0.77 | MAPK1 (0.41) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL4691673 | 0.77 | HCRTR1 (0.38) | — | |
| SCHEMBL4692648 | 0.77 | HCRTR1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |