Sugi Predict

Sugi Predict / Compounds / SCHEMBL469144

SCHEMBL469144

SCHEMBL469144

CCCCC(C)c1ccc(O)cc1O

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TYR P14679 5/20 0.49
▸ HTT P42858 2/20 0.46
▸ TSHR P16473 2/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ TP53 P04637 1/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ ALOX5 P09917 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ SRC P12931 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL70058 0.93 TYR (0.51) TYRHTTTSHRMEN1TP53
SCHEMBL71452 0.89 TYR (0.49) TYRHTTTSHRMEN1TP53
SCHEMBL10532360 0.86 RORC (0.45) TYRHTTTSHRMEN1TP53
SCHEMBL28638697 0.84 SRC (0.60) HTTTSHRMEN1TP53MAPT
SCHEMBL18704829 0.84 ESR1 (0.42) TYRHTTTSHRMEN1TP53
SCHEMBL29477949 0.83 SRC (0.59) HTTTSHRMEN1TP53MAPT
Potassium SCHEMBL29477955 0.83 SRC (0.59) HTTTSHRMEN1TP53MAPT
SCHEMBL18986199 0.81 TYR (0.49) TYRSRC
SCHEMBL1104213 0.81 TSHR (0.61) TYRTSHRALOX15
SCHEMBL29492442 0.81 TSHR (0.61) TYRTSHRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8318217-B2 Compositions comprising an anti-inflammatory blend JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2012-11-27 — — US disclosed
US-20120128613-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR 2012-05-24 — — US disclosed
US-20120128605-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT JOHNSON & JOHNSON CONSUMER INC. 2012-05-24 — — US disclosed
US-20120101156-A1 COMPOSITIONS COMPRISING A RETINOID AND AN NFkB-INHIBITOR AND THEIR METHODS OF USE KENVUE BRANDS LLC 2012-04-26 — — US disclosed
US-20120064149-A1 HIGH-CLARITY AQUEOUS CONCENTRATES OF 4-HEXYLRESORCINOL JOHNSON KALONDA TYMIKA (US) 2012-03-15 — — US disclosed
US-20120045492-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF JOHNSON & JOHNSON CONSUMER COMPANIES, INC. 2012-02-23 — — US disclosed
US-20120045529-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF KENVUE BRANDS LLC 2012-02-23 — — US disclosed
US-20120045491-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF KENVUE BRANDS LLC 2012-02-23 — — US disclosed
US-20120045531-A1 METHODS OF TREATING CELLULITE KENVUE BRANDS LLC 2012-02-23 — — US disclosed
US-20120045407-A1 COMPOSITIONS COMPRISING PAULOWNIN AND/OR PAULOWNIA EXTRACTS AND USES THEREOF KENVUE BRANDS LLC 2012-02-23 — — US disclosed
US-8084504-B2 High-clarity aqueous concentrates of 4-hexylresorcinol JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2011-12-27 — — US disclosed
US-8075930-B2 Extracts of Phyllanthus niruri JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2011-12-13 — — US disclosed
US-8075931-B2 Extracts of Phyllanthus niruri JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2011-12-13 — — US disclosed
US-20110081431-A1 COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A NON-RETINOID COLLAGEN PROMOTER KENVUE BRANDS LLC 2011-04-07 — — US disclosed
US-20110082217-A1 HIGH-CLARITY AQUEOUS CONCENTRATES OF 4-HEXYLRESORCINOL KENVUE BRANDS LLC 2011-04-07 — — US disclosed
US-20110081430-A1 COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER JOHNSON & JOHNSON CONSUMER COMPANIES, INC. 2011-04-07 — — US disclosed
US-20110081433-A1 COMPOSITIONS COMPRISING AN ANTI-INFLAMMATORY BLEND JOHNSON & JOHNSON CONSUMER INC. 2011-04-07 — — US disclosed
US-20110081305-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT JOHNSON & JOHNSON CONSUMER COMPANIES, INC. 2011-04-07 — — US disclosed
US-20110081308-A1 EXTRACTS OF PHYLLANTHUS NIRURI JOHNSON & JOHNSON CONSUMER INC. 2011-04-07 — — US disclosed
US-20110081432-A1 EXTRACTS OF PHYLLANTHUS NIRURI JOHNSON & JOHNSON CONSUMER INC. 2011-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120045492-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF CAT, TEX10, CD68 TYR 596/4885HTT 1635/4885TSHR 4574/4885
US-20120045491-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF CAT, TEX10, CD68 TYR 596/4885HTT 1635/4885TSHR 4574/4885
US-20110081431-A1 COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A NON-RETINOID COLLAGEN PROMOTER NFKBIA, NFRKB, NFKB1 TYR 4184/4885HTT 3686/4885TSHR 3297/4885
US-20120045407-A1 COMPOSITIONS COMPRISING PAULOWNIN AND/OR PAULOWNIA EXTRACTS AND USES THEREOF PNN, CUTA, NCL TYR 30/4885HTT 3270/4885TSHR 4845/4885
US-20120128605-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT CUTA, NQO1, RBP4 TYR 5/4885HTT 1074/4885TSHR 4410/4885
US-20120045529-A1 COMPOSITIONS COMPRISING PAULOWNIA TOMENTOSA WOOD EXTRACTS AND USES THEREOF CAT, TEX10, CD68 TYR 596/4885HTT 1635/4885TSHR 4574/4885
US-20120101156-A1 COMPOSITIONS COMPRISING A RETINOID AND AN NFkB-INHIBITOR AND THEIR METHODS OF USE NFKBIA, NFKB2, NFKB1 TYR 1074/4885HTT 3568/4885TSHR 4236/4885
US-20120064149-A1 HIGH-CLARITY AQUEOUS CONCENTRATES OF 4-HEXYLRESORCINOL RFC4, RBP4, KEAP1 TYR 838/4885HTT 16/4885TSHR 4235/4885
US-20120045531-A1 METHODS OF TREATING CELLULITE CUTA, PYGM, FABP4 TYR 159/4885HTT 4243/4885TSHR 4538/4885
US-20110081430-A1 COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER NFKBIA, NFKB1, NFKB2 TYR 199/4885HTT 620/4885TSHR 4455/4885
US-20110081308-A1 EXTRACTS OF PHYLLANTHUS NIRURI CUTA, COLGALT1, COL1A1 TYR 224/4885HTT 2143/4885TSHR 4484/4885
US-20110081433-A1 COMPOSITIONS COMPRISING AN ANTI-INFLAMMATORY BLEND NFKBIA, NFKB2, NFKB1 TYR 2278/4885HTT 1636/4885TSHR 4885/4885
US-20120128613-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT CUTA, NQO1, RBP4 TYR 5/4885HTT 1074/4885TSHR 4410/4885
US-20110082217-A1 HIGH-CLARITY AQUEOUS CONCENTRATES OF 4-HEXYLRESORCINOL RFC4, RBP4, KEAP1 TYR 838/4885HTT 16/4885TSHR 4235/4885
US-20110081432-A1 EXTRACTS OF PHYLLANTHUS NIRURI CUTA, COLGALT1, COL1A1 TYR 224/4885HTT 2143/4885TSHR 4484/4885
US-20110081305-A1 COMPOSITIONS COMPRISING A SKIN-LIGHTENING RESORCINOL AND A SKIN DARKENING AGENT CUTA, NQO1, RBP4 TYR 5/4885HTT 1074/4885TSHR 4410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.