Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14575602 | 0.88 | G6PD (0.41) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL14575603 | 0.88 | G6PD (0.41) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL264463 | 0.79 | G6PD (0.38) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL39273 | 0.79 | G6PD (0.38) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL14617615 | 0.73 | G6PD (0.45) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL18712230 | 0.73 | LTB4R (0.39) | TDP1FBP1ALDH1A1KMT2APRMT1 | |
| SCHEMBL1404270 | 0.70 | G6PD (0.42) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL7258762 | 0.69 | ALDH1A1 (0.43) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL7258759 | 0.69 | ALDH1A1 (0.43) | G6PDTDP1FBP1ALDH1A1KMT2A | |
| SCHEMBL268060 | 0.68 | BCHE (0.41) | G6PDTDP1FBP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922075-A2 | ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS | Oklahoma Medical Research Foundation (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007019065-A2 | ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20070032453-A1 | ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2007-02-08 | — | — | US | disclosed |
| US-20050272724-A1 | Spin trapping pharmaceutical compositions and methods for use thereof | CARNEY JOHN M | 2005-12-08 | — | — | US | disclosed |
| US-20050107366-A1 | Spin trapping pharmaceutical compositions and methods for use thereof | CARNEY JOHN M (US) | 2005-05-19 | — | — | US | disclosed |
| US-6403627-B1 | FOR TREATMENT OF DYSFUNCTIONS AND DISEASE CONDITIONS ARISING FROM OXIDATIVE DAMAGE; PHENYL N-TERT-BUTYLNITRONE DERIVATIVES | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2002-06-11 | — | — | US | disclosed |
| EP-0590072-B1 | USE OF SPIN TRAPPING FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATION OF LIPIDS AND PROTEINS | OKLAHOMA MED RES FOUND (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0949915-A4 | NITRONE FREE RADICAL TRAP TREATMENT OF DEMENTIA ASSOCIATED WITH AIDS VIRUS (HIV-1) INFECTION | OKLAHOMA MED RES FOUND (US) | 2001-07-04 | — | — | EP | disclosed |
| US-6107315-A | Method of treatment of conditions associated with oxidative tissue damage | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0736004-B1 | (2,4-DISULFOPHENYL) N-TERTIARY BUTYL NITRONE, ITS SALTS, AND THEIR USE AS PHARMACEUTICAL RADICAL TRAPPING AGENTS | OKLAHOMA MED RES FOUND (US) | 2000-05-10 | — | — | EP | disclosed |
| EP-0496796-B1 | METHOD AND COMPOSITIONS FOR INHIBITION OF DISORDERS ASSOCIATED WITH OXIDATIVE DAMAGE | OKLAHOMA MED RES FOUND (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0590072-A1 | USE OF SPIN TRAPPING FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATION OF LIPIDS AND PROTEINS | Oklahoma Medical Research Foundation (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0518951-A4 | PHENYL BUTYL NITRONE COMPOSITIONS FOR PREVENTION OF GASTRIC ULCERATION | — | 1993-02-24 | — | — | EP | disclosed |
| EP-0518951-A1 | PHENYL BUTYL NITRONE COMPOSITIONS FOR PREVENTION OF GASTRIC ULCERATION | Oklahoma Medical Research Foundation (US) | 1992-12-23 | — | — | EP | disclosed |
| WO-1992022290-A1 | USE OF SPIN TRAPPING FOR THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATION OF LIPIDS AND PROTEINS | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 1992-12-23 | — | — | WO | disclosed |
| EP-0496796-A1 | METHOD AND COMPOSITIONS FOR INHIBITION OF DISORDERS ASSOCIATED WITH OXIDATIVE DAMAGE. | OKLAHOMA MED RES FOUND (US) | 1992-08-05 | — | — | EP | disclosed |
| WO-1991013618-A1 | PHENYL BUTYL NITRONE COMPOSITIONS FOR PREVENTION OF GASTRIC ULCERATION | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 1991-09-19 | — | — | WO | disclosed |
| US-5036097-A | Antiinflammatory agents/non-steriodal | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 1991-07-30 | — | — | US | disclosed |
| US-5025032-A | For ischemia or inflammation of brain or nervous system | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 1991-06-18 | — | — | US | disclosed |
| WO-1991005552-A1 | METHOD AND COMPOSITIONS FOR INHIBITION OF DISORDERS ASSOCIATED WITH OXIDATIVE DAMAGE | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 1991-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272724-A1 | Spin trapping pharmaceutical compositions and methods for use thereof | PPOX, TXN2, TXN | G6PD 651/4885TDP1 279/4885FBP1 1971/4885 |
| US-20050107366-A1 | Spin trapping pharmaceutical compositions and methods for use thereof | PPOX, TXN2, TXN | G6PD 651/4885TDP1 279/4885FBP1 1971/4885 |
| US-20070032453-A1 | ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS | MGMT, NOS3, NNMT | G6PD 153/4885TDP1 1105/4885FBP1 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.