Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807922 | 0.84 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL3868022 | 0.76 | MAPT (0.53) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL29881669 | 0.76 | ALDH1A1 (0.72) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL18074682 | 0.76 | LMNA (0.53) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL79949 | 0.76 | LMNA (0.53) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL5498592 | 0.76 | ALDH1A1 (0.72) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL11543811 | 0.73 | PARP1 (0.50) | MAPTALDH1A1PARP1RAB9ASMN1; SMN2 | |
| SCHEMBL18122808 | 0.72 | MAOA (0.59) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL17272797 | 0.72 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAHTTKDM4E | |
| SCHEMBL8807782 | 0.72 | KDM4E (0.48) | MAPTALDH1A1LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1262181-B1 | USE OF ISOTHIAZOLE DERIVATIVES AS UREASE INHIBITORS FOR THE TREATMENT OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | OTSUKA PHARMA CO LTD (JP) | 2007-05-16 | — | — | EP | claimed |
| US-20040058952-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. | 2004-03-25 | — | — | US | claimed |
| US-20030060482-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-27 | — | — | US | claimed |
| EP-1262181-A1 | UREASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-04 | — | — | EP | claimed |
| US-20180296505-A1 | BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS | STC UNM (US) | 2018-10-18 | — | — | US | disclosed |
| US-20170056345-A1 | BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS | STC.UNM | 2017-03-02 | — | — | US | disclosed |
| EP-2042334-A2 | Method of producing heat-sensitive transfer image-receiving sheet | Fujifilm Corporation (JP) | 2009-04-01 | — | — | EP | disclosed |
| EP-1948659-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007085540-A1 | 1H-INDAZ0L-4-YL-2 , 4-PYRIMIDINEDIAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-08-02 | — | — | WO | disclosed |
| EP-1262181-B1 | USE OF ISOTHIAZOLE DERIVATIVES AS UREASE INHIBITORS FOR THE TREATMENT OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | OTSUKA PHARMA CO LTD (JP) | 2007-05-16 | — | — | EP | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |
| WO-2006129100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-12-07 | — | — | WO | disclosed |
| US-20040058952-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. | 2004-03-25 | — | — | US | disclosed |
| US-20030060482-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-27 | — | — | US | disclosed |
| EP-1262181-A1 | UREASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-5834601-A | DYEING CELLULOSE, WOOL, POLYAMIDE | DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) | 1998-11-10 | — | — | US | disclosed |
| US-5187265-A | Medical diagnosis | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5187105-A | Process for determining thiols using chromogenic benzoisothiazolone derivatives | MILES INC. (US) | 1993-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060482-A1 | Urease inhibitors | PGC, SLC14A1, USP1 | MAPT 3175/4885ALDH1A1 592/4885LMNA 4823/4885 |
| US-20180296505-A1 | BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS | TREH, ACHE, UMPS | MAPT 883/4885ALDH1A1 833/4885LMNA 4111/4885 |
| US-20040058952-A1 | Urease inhibitors | PGC, SLC14A1, USP1 | MAPT 3175/4885ALDH1A1 592/4885LMNA 4823/4885 |
| US-20170056345-A1 | BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS | TREH, ACHE, UMPS | MAPT 883/4885ALDH1A1 833/4885LMNA 4111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.