SCHEMBL4823690

SCHEMBL4823690

COc1ccc2c(c1)[nH]c1cnccc12

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHUK O15111 2/20 0.79
ACHE P22303 3/20 0.62
DYRK1A Q13627 11/20 0.57
CLK1 P49759 5/20 0.57
CDK5 Q00535 5/20 0.57
CDK5R1 Q15078 5/20 0.57
CLK2 P49760 3/20 0.57
CLK3 P49761 3/20 0.57
CLK4 Q9HAZ1 3/20 0.57
DYRK1B Q9Y463 3/20 0.57
KDM4E B2RXH2 3/20 0.57
ALDH1A1 P00352 3/20 0.57
HPGD P15428 3/20 0.57
HSD17B10 Q99714 2/20 0.57
MAOA P21397 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
DYRK3 O43781 1/20 0.57
CCNT1 O60563 1/20 0.57
CCNB2 O95067 1/20 0.57
CYP1A2 P05177 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3685010 0.89 CHUK (1.00) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL29986061 0.89 CHUK (1.00) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL27098859 0.89 ACHE (0.79) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL30667681 0.89 ACHE (0.79) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL20483684 0.86 CHUK (0.59) CHUKACHEKDM4EALDH1A1HPGD
SCHEMBL29533596 0.84 KDM4E (0.68) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL2330779 0.84 KDM4E (0.68) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL17520087 0.83 CHUK (0.56) CHUKDYRK1AKDM4EALDH1A1HPGD
SCHEMBL30667654 0.81 CHUK (0.54) CHUKACHEDYRK1ACLK1CDK5
SCHEMBL24277835 0.79 DYRK1A (0.60) CHUKACHEDYRK1ACLK1CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111787945-B Engineered nanovesicles as checkpoint blockers for cancer immunotherapy 北卡罗莱纳州立大学 2024-11-29 CN claimed
CN-113782760-B MOF material and preparation method thereof, proton exchange membrane and preparation method thereof, and fuel cell 深圳氢时代新能源科技有限公司 2022-11-08 CN claimed
US-20220125809-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH STAMETS PAUL EDWARD (US) 2022-04-28 US claimed
US-12622940-B2 Combined fungal composition for modulating an inflammatory response TURTLE BEAR HOLDINGS, LLC (US) 2026-05-12 US disclosed
US-12622938-B2 Compositions and methods for modulating inflammatory response TURTLE BEAR HOLDINGS, LLC (US) 2026-05-12 US disclosed
US-20260108544-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS LLC (US) 2026-04-23 US disclosed
US-20260048048-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS LLC (US) 2026-02-19 US disclosed
US-20250325533-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS LLC (US) 2025-10-23 US disclosed
US-12403150-B2 Tryptamine compositions for enhancing neurite outgrowth TURTLE BEAR HOLDINGS, LLC (US) 2025-09-02 US disclosed
US-20250205254-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS LLC (US) 2025-06-26 US disclosed
US-20250177354-A1 THERAPEUTIC COMBINATIONS, COMPOSITIONS, AND METHODS FOR DESIGNING AND PRODUCING ENTACTOGENIC MINDSTATES MINDSTATE DESIGN LABS INC (US) 2025-06-05 US disclosed
US-20210069170-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH TURTLE BEAR HOLDINGS, LLC 2021-03-11 US disclosed
US-10381578-B2 Organometallic compound and organic light-emitting device including the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2019-08-13 US disclosed
US-7348336-B2 Substituted β-carbolines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-03-25 US disclosed
US-7348336-B2 Substituted β-carbolines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-03-25 US disclosed
US-7348336-B2 Substituted β-carbolines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-03-25 US disclosed
US-20060166978-A1 Substituted beta carbolines SANOFI-AVENTIS DEUTSCHLAND GMBH 2006-07-27 US disclosed
US-7026331-B2 Substituted beta-carbolines SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2006-04-11 US disclosed
US-20040110759-A1 Substituted beta carbolines AVENTIS PHARMA DEUTSCHLAND GMBH 2004-06-10 US disclosed
US-6627637-B2 I kappa B kinase inhibitors for treating various disorders including arthritis AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2003-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12622940-B2 Combined fungal composition for modulating an inflammatory response SORD, ERG28, IL1B CHUK 1036/4885ACHE 1166/4885DYRK1A 2997/4885
US-20040110759-A1 Substituted beta carbolines CSNK1A1, CSNK2A1, CSNK2B CHUK 52/4885ACHE 904/4885DYRK1A 2551/4885
US-10381578-B2 Organometallic compound and organic light-emitting device including the same L1CAM, MSL1, CHRM1 CHUK 3731/4885ACHE 961/4885DYRK1A 4546/4885
US-12622938-B2 Compositions and methods for modulating inflammatory response IL1B, IL1R1, ERG28 CHUK 1909/4885ACHE 1979/4885DYRK1A 2438/4885
US-12403150-B2 Tryptamine compositions for enhancing neurite outgrowth HTR1B, HTR6, BDNF CHUK 2664/4885ACHE 32/4885DYRK1A 1663/4885
US-20250177354-A1 THERAPEUTIC COMBINATIONS, COMPOSITIONS, AND METHODS FOR DESIGNING AND PRODUCING ENTACTOGENIC MINDSTATES CNR2, CNR1, HTR6 CHUK 1412/4885ACHE 368/4885DYRK1A 711/4885
US-20260048048-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF CHUK 2856/4885ACHE 40/4885DYRK1A 2215/4885
US-20250325533-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, BDNF, HTR6 CHUK 2779/4885ACHE 35/4885DYRK1A 1607/4885
US-20210069170-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF CHUK 2664/4885ACHE 32/4885DYRK1A 1663/4885
US-20220125809-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF CHUK 2664/4885ACHE 32/4885DYRK1A 1663/4885
US-20060166978-A1 Substituted beta carbolines NFKBIA, RELA, IKBKG CHUK 8/4885ACHE 2205/4885DYRK1A 3941/4885
US-20250205254-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF CHUK 2664/4885ACHE 32/4885DYRK1A 1663/4885
US-20260108544-A1 TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH HTR1B, HTR6, BDNF CHUK 3444/4885ACHE 30/4885DYRK1A 825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.