Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiobenzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.42 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.42 |
| ▸ | PAM | P19021 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28550151 | 0.89 | PAM (0.50) | PAMALOX15TDP1MAPK1KMT2A | |
| Thiobenzoic Acid SCHEMBL162937 | 0.84 | PAM (0.46) | PAMALOX15TDP1MAPK1KMT2A | |
| Thiobenzoic Acid SCHEMBL10793587 | 0.81 | PAM (0.43) | PAMALOX15TDP1MAPK1KMT2A | |
| Thiobenzoic Acid SCHEMBL28582374 | 0.75 | CA2 (0.55) | CA2CA4TDP1KMT2ACES1 | |
| Thiobenzoic Acid SCHEMBL29374102 | 0.75 | CA2 (0.55) | CA2CA4TDP1KMT2ACES1 | |
| Thiobenzoic Acid SCHEMBL2165575 | 0.75 | CA2 (0.55) | CA2CA4TDP1KMT2ACES1 | |
| Thiobenzoic Acid SCHEMBL28468362 | 0.73 | CA2 (0.52) | CA2CA4TDP1KMT2ACES1 | |
| Thiobenzoic Acid SCHEMBL28345225 | 0.73 | CA2 (0.52) | CA2CA4TDP1KMT2ACES1 | |
| Thiobenzoic Acid SCHEMBL9416254 | 0.73 | NPC1 (0.43) | CES1MAPTALDH1A1PTPN1CES2 | |
| SCHEMBL14740677 | 0.72 | ERCC5 (0.47) | TDP1KMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402690-B2 | Chain transfer agents for raft polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2008-07-22 | — | — | US | disclosed |
| US-20070123670-A1 | Chain transfer agents for raft polymerization in aqueous media | MCCORMICK CHARLES L | 2007-05-31 | — | — | US | disclosed |
| US-7186786-B2 | Chain transfer agents for RAFT polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2007-03-06 | — | — | US | disclosed |
| US-7179872-B2 | Chain transfer agents for RAFT polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2007-02-20 | — | — | US | disclosed |
| US-20060111531-A1 | Chain transfer agents for RAFT polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI | 2006-05-25 | — | — | US | disclosed |
| US-20060111532-A1 | Chain transfer agents for RAFT polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI | 2006-05-25 | — | — | US | disclosed |
| US-6855840-B2 | Chain transfer agents for raft polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030195310-A1 | Chain transfer agents for raft polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI | 2003-10-16 | — | — | US | disclosed |
| US-20030191262-A1 | Chain transfer agents for raft polymerization in aqueous media | UNIVERSITY OF SOUTHERN MISSISSIPPI | 2003-10-09 | — | — | US | disclosed |
| WO-2003066685-A2 | CHAIN TRANSFER AGENTS FOR RAFT POLYMERIZATION IN AQUEOUS MEDIA | UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195310-A1 | Chain transfer agents for raft polymerization in aqueous media | TRRAP, NEFM, TMT1A | CA2 1845/4885CA4 812/4885PAM 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.