Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 5/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977891 | 1.00 | OSBP (0.43) | OSBPCHRNA7CYP3A4MEN1MAPT | |
| SCHEMBL14201287 | 0.93 | MAOB (0.43) | OSBPMAPTKMT2AMAPK1ALDH1A1 | |
| SCHEMBL14523859 | 0.83 | PTPN1 (0.47) | CHRNA7CYP3A4MEN1MAPTHPGD | |
| SCHEMBL4982221 | 0.76 | PTPN1 (0.51) | CHRNA7CYP3A4MEN1MAPTHPGD | |
| SCHEMBL5519370 | 0.76 | PTPN1 (0.51) | CHRNA7CYP3A4MEN1MAPTHPGD | |
| SCHEMBL15620334 | 0.76 | NFKB1 (0.48) | CHRNA7CYP3A4MEN1MAPTHPGD | |
| SCHEMBL15620335 | 0.72 | NFKB1 (0.48) | CHRNA7CYP3A4MEN1MAPTHPGD | |
| SCHEMBL14523845 | 0.71 | MAOB (0.52) | CYP3A4MEN1MAPTHPGDKMT2A | |
| SCHEMBL5997891 | 0.71 | MAOB (0.52) | CYP3A4MEN1MAPTHPGDKMT2A | |
| SCHEMBL14518094 | 0.70 | MAOB (0.45) | MEN1MAPTKMT2AMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070092551-A1 | Therapeutic agent | TAKARA BIO INC. (JP) | 2007-04-26 | — | — | US | claimed |
| EP-1623704-A1 | THERAPEUTIC AGENT | TAKARA BIO INC. (JP) | 2006-02-08 | — | — | EP | claimed |
| US-7361774-B2 | Chalcone compound | TAKARA BIO INC. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-20080008773-A1 | Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species | OHNOGI HIROMU | 2008-01-10 | — | — | US | disclosed |
| US-20070092551-A1 | Therapeutic agent | TAKARA BIO INC. (JP) | 2007-04-26 | — | — | US | disclosed |
| US-20060039998-A1 | Remedies | TAKARA BIO INC. (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-1623704-A1 | THERAPEUTIC AGENT | TAKARA BIO INC. (JP) | 2006-02-08 | — | — | EP | disclosed |
| US-20050272809-A1 | Remedies | TAKARA BIO INC. (JP) | 2005-12-08 | — | — | US | disclosed |
| EP-1574506-A1 | REMEDIES | TAKARA BIO INC. (JP) | 2005-09-14 | — | — | EP | disclosed |
| EP-1563841-A1 | REMEDIES | TAKARA BIO INC. (JP) | 2005-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080008773-A1 | Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species | BMP2, BMP1, BMP4 | OSBP 309/4885CHRNA7 4816/4885CYP3A4 4790/4885 |
| US-20050272809-A1 | Remedies | NOS2, AKR1C3, CBR1 | OSBP 438/4885CHRNA7 734/4885CYP3A4 2724/4885 |
| US-20070092551-A1 | Therapeutic agent | FABP4, GPR119, IAPP | OSBP 486/4885CHRNA7 4487/4885CYP3A4 3641/4885 |
| US-20060039998-A1 | Remedies | BMP2, BMP1, BMP6 | OSBP 201/4885CHRNA7 4571/4885CYP3A4 4862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.