Sugi Predict

Sugi Predict / Compounds / SCHEMBL500232

SCHEMBL500232

SCHEMBL500232

Fc1ccc(-c2cs[c]n2)cc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 5/20 0.46
▸ ALOX5 P09917 3/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ AR P10275 3/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ NPC1 O15118 4/20 0.38
▸ ATP4A P20648 2/20 0.38
▸ ATP4B P51164 2/20 0.38
▸ NPY5R Q15761 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ MAPK10 P53779 1/20 0.35
▸ MAPK14 Q16539 1/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3415318 0.81 ALDH1A3 (0.58) RAB9AALDH1A1KDM4ENPC1SMN1; SMN2
SCHEMBL468050 0.80 KIF11 (0.50) ALOX5ALDH1A1KDM4EL3MBTL1MEN1
SCHEMBL7228611 0.79 RAB9A (0.44) RAB9AALDH1A1KDM4EL3MBTL1NPC1
SCHEMBL468044 0.79 RAB9A (0.41) RAB9AALOX5ALDH1A1KDM4EL3MBTL1
SCHEMBL10515566 0.79 LTA4H (0.46) RAB9AALDH1A1ARKDM4ENPC1
SCHEMBL1916309 0.79 KMT2A (0.47) RAB9AALDH1A1KDM4EL3MBTL1NPC1
SCHEMBL5540279 0.79 RAB9A (0.47) RAB9AALDH1A1ARKDM4ENPC1
SCHEMBL2752236 0.79 RAB9A (0.41) RAB9AALDH1A1KDM4EL3MBTL1NPC1
SCHEMBL70645 0.78 ALDH1A1 (0.42) RAB9AALDH1A1ARKDM4EL3MBTL1
SCHEMBL443517 0.78 LMNA (0.43) RAB9AARKDM4ENPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3919486-B1 NOVEL HETEROARYL-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2023-06-07 — — EP claimed
US-10076517-B2 Methods and pharmaceutical compositions for the treatment of fibrosis INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE KA RECHERCHE MÉDICALE (FR) 2018-09-18 — — US claimed
CN-105339370-B Compound and and its pharmaceutical composition for treating diseases associated with inflammation 加拉帕戈斯股份有限公司 2017-09-15 — — CN claimed
CN-105339370-A Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders GALAPAGOS NV 2016-02-17 — — CN claimed
CN-102459167-B Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA NV 2015-04-01 — — CN claimed
EP-2038265-B1 Human protein-tyrosine phosphatase inhibitors and methods of use AERPIO THERAPEUTICS INC (US) 2015-03-18 — — EP claimed
EP-2421825-B9 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-20 — — EP claimed
US-8691805-B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2014-04-08 — — US claimed
EP-2421825-B1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2014-01-01 — — EP claimed
US-20130244997-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (US) 2013-09-19 — — US claimed
US-20080004267-A1 Human protein tyrosine phosphatase inhibitors and methods of use THE PROCTER & GAMBLE COMPANY (US) 2008-01-03 — — US claimed
US-20070259925-A1 DPP IV INHIBITORS BOEHRINGER MARKUS 2007-11-08 — — US claimed
CN-1713907-A N-substituted pyrrolidine derivatives as dipeptidyl peptidase IV inhibitors HOFFMANN LA ROCHE (CH) 2005-12-28 — — CN claimed
US-20050096348-A1 DPP IV inhibitors BOEHRINGER MARKUS (CH) 2005-05-05 — — US claimed
EP-1441719-A1 N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-08-04 — — EP claimed
US-20030130281-A1 DPP IV inhibitors HOFFMAN-LA ROCHE INC. 2003-07-10 — — US claimed
WO-2003037327-A1 N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS F. HOFFMANN-LA-ROCHE AG (CH) 2003-05-08 — — WO claimed
WO-2001074793-A2 SUBSTITUTED THIAZOLES AND THE USE THEREOF AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2001-10-11 — — WO claimed
EP-0476455-B1 Phenyl-substituted 2-thiazolyl tetrazolium salt indicators BAYER AG (US) 1998-11-04 — — EP claimed
US-5290536-A Phenyl substituted 2-thiazolyl tetrazolium salt indicators MILES INC. (US) 1994-03-01 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10076517-B2 Methods and pharmaceutical compositions for the treatment of fibrosis LIPA, MGLL, PNLIP RAB9A 3523/4885ALOX5 93/4885ALDH1A1 779/4885
US-20130244997-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA RAB9A 851/4885ALOX5 154/4885ALDH1A1 364/4885
US-20070259925-A1 DPP IV INHIBITORS DPP4, DPP3, DPP7 RAB9A 3061/4885ALOX5 4546/4885ALDH1A1 233/4885
US-20030130281-A1 DPP IV inhibitors DPP4, DPP3, DPP7 RAB9A 3016/4885ALOX5 4663/4885ALDH1A1 133/4885
US-20050096348-A1 DPP IV inhibitors DPP4, DPP3, DPP7 RAB9A 3061/4885ALOX5 4546/4885ALDH1A1 233/4885
US-20080004267-A1 Human protein tyrosine phosphatase inhibitors and methods of use PTPRCAP, PTPRC, PPP5C RAB9A 2893/4885ALOX5 4329/4885ALDH1A1 4349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.