Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010705 | 0.92 | HTR1B (0.46) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL5010596 | 0.90 | HTR1B (0.41) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL5009727 | 0.89 | HTR1B (0.40) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL2338566 | 0.86 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KMT2ACYP2A6L3MBTL1 | |
| SCHEMBL516226 | 0.77 | SIGMAR1 (0.48) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL1573639 | 0.75 | ALDH1A1 (0.41) | SIGMAR1ALDH1A1KMT2ACYP2A6MMP9 | |
| SCHEMBL9313557 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL5012208 | 0.75 | SIGMAR1 (0.43) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A | |
| SCHEMBL7411647 | 0.74 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1KMT2ACYP2A6L3MBTL1 | |
| SCHEMBL7772408 | 0.74 | SIGMAR1 (0.53) | SIGMAR1HTR1BHTR1DALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| US-7071211-B2 | Small organic molecules that increase the activity of gelatinase a in ocular cells | BAUSCH & LOMB INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20060121090-A1 | Ocular compositions that increases the activity of gelatinase a in ocular cells | BAUSCH & LOMB INCORPORATED | 2006-06-08 | — | — | US | disclosed |
| EP-1542687-A1 | SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS | BAUSCH & LOMB INCORPORATED (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004028538-A1 | SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS | BAUSCH & LOMB INCORPORATED (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040068017-A1 | Small organic molecules that increase the activity of Gelatinase A in ocular cells | BAUSCH & LOMB INCORPORATED | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060121090-A1 | Ocular compositions that increases the activity of gelatinase a in ocular cells | MMP3, MMP13, MMP1 | SIGMAR1 4124/4885HTR1B 4277/4885HTR1D 4520/4885 |
| US-20040068017-A1 | Small organic molecules that increase the activity of Gelatinase A in ocular cells | MMP1, MMP3, MMP10 | SIGMAR1 2529/4885HTR1B 3749/4885HTR1D 4105/4885 |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | SIGMAR1 1156/4885HTR1B 4003/4885HTR1D 4198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.