Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044102 | 0.91 | MAPT (0.40) | CNR1MAPTHTR2AHTR2CSLC6A4 | |
| SCHEMBL5039421 | 0.87 | HTR2A (0.48) | CNR1HTR2AHTR2CSLC6A4CNR2 | |
| SCHEMBL5043850 | 0.87 | NCEH1 (0.41) | CNR1HTR2AHTR2CSLC6A4CNR2 | |
| SCHEMBL5044496 | 0.86 | ATP4A (0.37) | MAPT | |
| SCHEMBL5047187 | 0.86 | HDAC3 (0.36) | — | |
| SCHEMBL5047889 | 0.86 | MGLL (0.36) | MAPTHTR2AHTR2CSLC6A4 | |
| SCHEMBL5040330 | 0.85 | NTMT1 (0.40) | CNR1CNR2 | |
| SCHEMBL5048696 | 0.84 | CDC25A (0.43) | MAPT | |
| SCHEMBL5047653 | 0.84 | ATP4A (0.38) | MAPT | |
| SCHEMBL5040295 | 0.83 | DNM1L (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |