SCHEMBL509281

SCHEMBL509281

C=C1CCN(CCCC)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
HPGD P15428 3/20 0.46
KDM4E B2RXH2 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HSD17B10 Q99714 2/20 0.46
TSHR P16473 1/20 0.46
ALOX15 P16050 1/20 0.45
GRM5 P41594 3/20 0.42
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ALOX5 P09917 2/20 0.34
TP53 P04637 1/20 0.33
GAA P10253 1/20 0.33
GBA1 P04062 1/20 0.33
FAAH O00519 1/20 0.33
MGLL Q99685 1/20 0.33
THRB P10828 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL508661 0.88 GRM5 (0.39) ALDH1A1NPC1RAB9AHPGDKDM4E
SCHEMBL30778313 0.80 ALDH1A1 (0.48) ALDH1A1NPC1RAB9AHPGDKDM4E
SCHEMBL508107 0.79
SCHEMBL22728341 0.76 KMT2A (0.32) KMT2A
SCHEMBL11419141 0.75
SCHEMBL1725665 0.74 ALDH1A1 (0.43) ALDH1A1NPC1RAB9AHPGDKDM4E
SCHEMBL18530458 0.71
SCHEMBL22728272 0.71 TSHR (0.41) TSHR
SCHEMBL4424409 0.70 MEN1 (0.45) ALDH1A1NPC1RAB9AHPGDKDM4E
SCHEMBL25756596 0.70 MEN1 (0.45) ALDH1A1NPC1RAB9AHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 727 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12638614-B2 Method for making silicone hydrogel contact lenses ALCON INC. (CH) 2026-05-26 US claimed
US-20260132236-A1 LIGHT ABSORBERS FOR OPHTHALMC LENS MATERALS AND DEVICES ALCON INC (CH) 2026-05-14 US claimed
US-20260131506-A1 METHOD FOR MAKING EMBEDDED HYDROGEL CONTACT LENSES ALCON INC (CH) 2026-05-14 US claimed
US-12595368-B2 UV/HEVL-filtering contact lenses ALCON INC. (CH) 2026-04-07 US claimed
EP-4713721-A1 UV/HEVL-FILTERING SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2026-03-25 EP claimed
US-12570784-B2 Method for making embedded hydrogel contact lenses ALCON INC. (CH) 2026-03-10 US claimed
EP-4514596-B1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES ALCON INC (CH) 2026-03-04 EP claimed
EP-3759528-B1 SILICONE HYDROGEL CONTACT LENSES ALCON INC (CH) 2026-03-04 EP claimed
US-20260042269-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES ALCON INC (CH) 2026-02-12 US claimed
US-20260042268-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES ALCON INC (CH) 2026-02-12 US claimed
US-20120029111-A1 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF ALCON INC. (CH) 2012-02-02 US claimed
WO-2012016097-A2 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF NOVARTIS AG (CH) 2012-02-02 WO claimed
WO-2012016098-A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING NOVARTIS AG (CH) 2012-02-02 WO claimed
WO-2011075377-A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011071790-A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES NOVARTIS AG (CH) 2011-06-16 WO claimed
US-20110140292-A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS ALCON INC. (CH) 2011-06-16 US claimed
US-20110133350-A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES ALCON INC. (CH) 2011-06-09 US claimed
WO-2011056761-A1 A SILICONE HYDROGEL LENS WITH A GRAFTED HYDROPHILIC COATING NOVARTIS AG (CH) 2011-05-12 WO claimed
US-20110102736-A1 SILICONE HYDROGEL LENS WITH A GRAFTED HYDROPHILIC COATING ALCON INC. (CH) 2011-05-05 US claimed
US-20100298446-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS ALCON INC. (CH) 2010-11-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132236-A1 LIGHT ABSORBERS FOR OPHTHALMC LENS MATERALS AND DEVICES RAD51, ERCC1, LANCL2 ALDH1A1 1638/4885NPC1 3423/4885RAB9A 4861/4885
US-20260042269-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES CRYZ, STRA6, PHOSPHO1 ALDH1A1 1714/4885NPC1 3265/4885RAB9A 3206/4885
US-20100298446-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS ATRIP, ATR, MACF1 ALDH1A1 1684/4885NPC1 4834/4885RAB9A 4042/4885
US-12595368-B2 UV/HEVL-filtering contact lenses UACA, HSPA4L, RAD54L ALDH1A1 1073/4885NPC1 3998/4885RAB9A 4835/4885
US-12570784-B2 Method for making embedded hydrogel contact lenses CRYAB, CRYZ, CRYAA ALDH1A1 2345/4885NPC1 3173/4885RAB9A 3508/4885
US-20120029111-A1 AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF PIGS, ELOVL1, HACD2 ALDH1A1 2932/4885NPC1 491/4885RAB9A 4312/4885
US-20260042268-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES STRA6, CRYZ, SMCHD1 ALDH1A1 969/4885NPC1 2645/4885RAB9A 2421/4885
US-12638614-B2 Method for making silicone hydrogel contact lenses SMCHD1, CRYAA, CRYZ ALDH1A1 2364/4885NPC1 4772/4885RAB9A 4110/4885
US-20260131506-A1 METHOD FOR MAKING EMBEDDED HYDROGEL CONTACT LENSES CRYZ, CRYAB, CRYAA ALDH1A1 905/4885NPC1 3947/4885RAB9A 4338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.