Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | AGER | Q15109 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM6A | O15550 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213767 | 0.85 | PARP1 (0.51) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL21449055 | 0.83 | KDM4E (0.57) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL31368527 | 0.81 | KDM4E (0.55) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL9826240 | 0.81 | LMNA (0.56) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL8629880 | 0.80 | CA1 (0.57) | KDM4ETDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL2705046 | 0.80 | P2RX7 (0.41) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL9363595 | 0.80 | P2RX7 (0.49) | NAPRTLMNAP2RX7CA1CA2 | |
| SCHEMBL6479557 | 0.79 | KMT2A (0.54) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL27310244 | 0.77 | KDM4E (0.50) | NAPRTKDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL8537341 | 0.76 | FTO (0.49) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113248427-B | Sulfonyl nicotinic acid derivative, amido nicotinic acid derivative, preparation method and application thereof | 苏州大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113248427-B | Sulfonyl nicotinic acid derivative, amido nicotinic acid derivative, preparation method and application thereof | 苏州大学 | 2023-05-02 | — | — | CN | disclosed |
| EP-2970296-B1 | PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-12-21 | — | — | EP | disclosed |
| EP-2970296-A1 | PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9050345-B2 | Pyrrolotriazines as potassium ion channel inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-06-09 | — | — | US | disclosed |
| WO-2014143610-A1 | PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140256719-A1 | PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2014-09-11 | — | — | US | disclosed |
| US-20070135399-A1 | Heteroaromatic sulphonamide prodrugs | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-06-14 | — | — | US | disclosed |
| US-5512535-A | PRE- AND POSTEMERGENCE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0165753-B1 | HERBICIDAL THIOPHENESULFONAMIDES AND PYRIDINESULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| EP-0314302-A2 | Herbicidal o-carbomethoxy-sulfonylureas | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| WO-1989002700-A2 | HERBICIDAL O-CARBOMETHOXYSULFONYLUREAS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-04-06 | — | — | WO | disclosed |
| US-4784684-A | Herbicidal pyridinesulfonamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-11-15 | — | — | US | disclosed |
| US-4668279-A | PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-05-26 | — | — | US | disclosed |
| EP-0165753-A2 | Herbicidal thiophenesulfonamides and pyridinesulfonamides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135399-A1 | Heteroaromatic sulphonamide prodrugs | SULT2A1, SULT1E1, SULT1A1 | NAPRT 79/4885KDM4E 1199/4885TDP1 1762/4885 |
| US-20140256719-A1 | PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS | KCNJ4, KCNJ2, KCNA4 | NAPRT 1471/4885KDM4E 1004/4885TDP1 2842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.