Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.75 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.75 |
| ▸ | JUN | P05412 | 4/20 | 0.70 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tylophorine SCHEMBL31497488 | 1.00 | HIF1A (0.75) | HIF1AEPAS1JUNEHMT2DRD1 | |
| (S)-Tylophorine SCHEMBL523625 | 1.00 | HIF1A (0.75) | HIF1AEPAS1JUNEHMT2DRD1 | |
| Tylophorine SCHEMBL30193979 | 1.00 | HIF1A (0.75) | HIF1AEPAS1JUNEHMT2DRD1 | |
| Tylophorine SCHEMBL8977400 | 1.00 | HIF1A (0.75) | HIF1AEPAS1JUNEHMT2DRD1 | |
| (S)-Tylophorine SCHEMBL30116767 | 1.00 | HIF1A (0.75) | HIF1AEPAS1JUNEHMT2DRD1 | |
| (S)-Tylophorine SCHEMBL5610438 | 0.99 | HIF1A (0.73) | HIF1AEPAS1JUNEHMT2 | |
| SCHEMBL13222745 | 0.96 | HIF1A (0.81) | HIF1AEPAS1JUNEHMT2 | |
| SCHEMBL30637462 | 0.96 | HIF1A (0.81) | HIF1AEPAS1JUNEHMT2 | |
| SCHEMBL13222766 | 0.94 | HIF1A (0.80) | HIF1AEPAS1JUNEHMT2 | |
| SCHEMBL13222824 | 0.93 | JUN (0.81) | HIF1AEPAS1JUNDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 267 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119504742-A | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-02-25 | — | — | CN | claimed |
| US-20240115678-A1 | PERSONALIZED MULTIDISCIPLINARY CANCER THERAPY | VELTMEYER JAMES (US) | 2024-04-11 | — | — | US | claimed |
| WO-2024026505-A2 | DISRUPTION OF TELOCYTE ACTIVITY | PATEL AMIT (US) | 2024-02-01 | — | — | WO | claimed |
| CN-116903617-A | Preparation method of 7-demethoxy tylophorine reference substance | 上海诗丹德标准技术服务有限公司 | 2023-10-20 | — | — | CN | claimed |
| CN-109422742-B | 9-substituted tylophorine derivative, preparation thereof and application thereof in activity of resisting tobacco mosaic virus | 南开大学 | 2021-07-06 | — | — | CN | claimed |
| CN-109418278-A | Application of the tylophorine dehydrogenation derivative in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | claimed |
| CN-109422742-A | 9 tylophorine derivatives replaced and its preparation and the application in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | claimed |
| CN-106866662-A | A kind of luxuriant and rich with fragrance a pair of horses going side by side Indolizidine alkaloid and preparation method thereof | 江西农业大学 | 2017-06-20 | — | — | CN | claimed |
| CN-106478589-A | Tylophorine contains trifluoromethyl derivative and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-106478590-A | Tylophorine fluorine-containing derivant and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-105130985-A | Phenanthroindolizidine alkaloid quaternary ammonium salt derivative and preparation and plant virus resisting application thereof | UNIV NANKAI | 2015-12-09 | — | — | CN | claimed |
| CN-103509012-A | Phenanthroindolizidine alkaloid C14-site aminated derivatives, and preparation and anti-plant virus activity thereof | UNIV NANKAI | 2014-01-15 | — | — | CN | claimed |
| CN-101899043-B | Tylophora ovata base analogs with anti-tumor activity and preparation method and use thereof | UNIV NANJING SCIENCE & TECH | 2013-06-05 | — | — | CN | claimed |
| CN-102827163-A | Method for extracting tylophorine from tylophora florlbunda | NANJING ZHENGLIANG MED TECH CO | 2012-12-19 | — | — | CN | claimed |
| CN-102649790-A | (13aS, 14S)-14-amino phenanthroindolizidine alkaloid derivatives and preparation as well as plant virus resisting activity thereof | UNIV NANKAI | 2012-08-29 | — | — | CN | claimed |
| CN-101899043-A | Tylophora ovata base analogs with anti-tumor activity and preparation method and use thereof | UNIV NANJING SCIENCE & TECH | 2010-12-01 | — | — | CN | claimed |
| CN-101875657-A | Application of tylophorine-type alkaloid organic acidic salt derivatives in pesticide | UNIV NANKAI | 2010-11-03 | — | — | CN | claimed |
| WO-2007046113-A2 | NOVEL PHARMACEUTICAL COMPOSITION COMPRISING ALKALOID AND PROCESS THEREOF | PANACEA BIOTEC LTD. (IN) | 2007-04-26 | — | — | WO | claimed |
| WO-2006003676-A1 | A NOVEL METHOD TO INHIBIT INFLAMMATION AND TUMOR GROWTH BY TYLOPHORA ALKALOIDS | SECRETARY, DEPARTMENT OF ATOMIC ENERGY (IN) | 2006-01-12 | — | — | WO | claimed |
| CN-122094703-A | Multichain chimeric polypeptides and their use in the treatment of advanced solid tumors | — | 2026-05-26 | — | — | CN | disclosed |
| CN-122094976-A | Multichain chimeric polypeptides and uses thereof | — | 2026-05-26 | — | — | CN | disclosed |
| CN-119504742-B | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-10-28 | — | — | CN | disclosed |
| CN-119504742-B | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-10-28 | — | — | CN | disclosed |
| EP-4408435-B1 | COMPOSITION COMPRISING HESPERIDIN, CITRAL AND SODIUM ALGINATE AS A FILM-FORMING SUBSTANCE FOR PROPHYLAXIS OF INFECTIONS | MVS PHARMA GMBH (DE) | 2025-08-13 | — | — | EP | disclosed |
| WO-2025096770-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | IMMUNITYBIO, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025096644-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF ADVANCED SOLID TUMORS | IMMUNITYBIO, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| US-20250136663-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | IMMUNITYBIO, INC. | 2025-05-01 | — | — | US | disclosed |
| US-20250134974-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF ADVANCED SOLID TUMORS | IMMUNITYBIO, INC. | 2025-05-01 | — | — | US | disclosed |
| CN-119552094-A | HDAC inhibitors, methods of making and uses thereof | 安徽中医药大学 | 2025-03-04 | — | — | CN | disclosed |
| WO-2025043183-A1 | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL CANCERS | EIGEN THERAPEUTICS INC. (US) | 2025-02-27 | — | — | WO | disclosed |
| CN-119504742-A | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-119504742-A | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-119504742-A | Total synthesis method of tylophorine and antofine | 陕西师范大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-119059850-B | Method for promoting domestication growth rate of tissue culture seedlings of radix ginseng tylophora and application | 云南省农业科学院药用植物研究所 | 2025-01-24 | — | — | CN | disclosed |
| WO-2025016002-A1 | METHOD FOR PREPARING REFERENCE SUBSTANCE OF ANTOFINE | 上海诗丹德标准技术服务有限公司 | 2025-01-23 | — | — | WO | disclosed |
| CN-119059850-A | Method for promoting domestication growth rate of tissue culture seedlings of radix ginseng tylophora and application | 云南省农业科学院药用植物研究所 | 2024-12-03 | — | — | CN | disclosed |
| WO-2024189607-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT | DIDENKO KIRILL (MX) | 2024-09-19 | — | — | WO | disclosed |
| EP-4408435-A1 | COMPOSITION COMPRISING HESPERIDIN, CITRAL AND A FILM-FORMING SUBSTANCE FOR PROPHYLAXIS OF INFECTIONS | MVS Pharma GmbH (DE) | 2024-08-07 | — | — | EP | disclosed |
| US-12024545-B2 | Methods of treating aging-related disorders | HCW Biologics, Inc. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12018071-B2 | Single-chain chimeric polypeptides and uses thereof | HCW Biologics, Inc. (US) | 2024-06-25 | — | — | US | disclosed |
| EP-4384200-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES | HCW Biologics, Inc. (US) | 2024-06-19 | — | — | EP | disclosed |
| US-12011496-B2 | Topical macqui berry formulation | Tracie Martyn International, Inc. (US) | 2024-06-18 | — | — | US | disclosed |
| US-11987619-B2 | Single-chain chimeric polypeptides and uses thereof | HCW Biologics, Inc. (US) | 2024-05-21 | — | — | US | disclosed |
| CN-117957013-A | Multichain chimeric polypeptides and their use in the treatment of liver disorders | HCW生物科技公司 | 2024-04-30 | — | — | CN | disclosed |
| US-20240132561-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2024-04-25 | — | — | US | disclosed |
| US-20240124543-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2024-04-18 | — | — | US | disclosed |
| US-20240124544-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2024-04-18 | — | — | US | disclosed |
| US-11957667-B2 | Inhibitors of positive strand RNA viruses | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2024-04-16 | — | — | US | disclosed |
| US-20240115678-A1 | PERSONALIZED MULTIDISCIPLINARY CANCER THERAPY | VELTMEYER JAMES (US) | 2024-04-11 | — | — | US | disclosed |
| WO-2024026505-A2 | DISRUPTION OF TELOCYTE ACTIVITY | PATEL AMIT (US) | 2024-02-01 | — | — | WO | disclosed |
| US-20240033256-A1 | INHIBITORS OF POSITIVE STRAND RNA VIRUSES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2024-02-01 | — | — | US | disclosed |
| US-11884712-B2 | Multi-chain chimeric polypeptides and uses thereof | HCW Biologics, Inc. (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230398151-A1 | METHODS FOR STIMULATING PROLIFERATION OR DIFFERENTIATION OF AN IMMUNE CELL WITH A MULTI-CHAIN CHIMERIC POLYPEPTIDE | HCW Biologics, Inc. (US) | 2023-12-14 | — | — | US | disclosed |
| CN-115541746-B | Construction method and identification method of fingerprint of different-base radix cynanchi atrati and Laogui | 广东一方制药有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117143133-A | Polysubstituted hydrogenated phenanthrene derivative, and preparation method and application thereof | 安徽师范大学 | 2023-12-01 | — | — | CN | disclosed |
| US-20230381238-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2023-11-30 | — | — | US | disclosed |
| US-20230372399-A1 | METHODS OF TREATING AGING-RELATED DISORDERS | IMMUNITYBIO, INC. | 2023-11-23 | — | — | US | disclosed |
| CN-116903617-A | Preparation method of 7-demethoxy tylophorine reference substance | 上海诗丹德标准技术服务有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116569844-B | Tissue culture rapid propagation method for inducing cluster buds by utilizing stem sections of ginseng tylophora | 云南省农业科学院药用植物研究所 | 2023-09-19 | — | — | CN | disclosed |
| US-20230272027-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2023-08-31 | — | — | US | disclosed |
| US-11738052-B2 | Multi-chain chimeric polypeptides and uses thereof | HCW Biologics, Inc. (US) | 2023-08-29 | — | — | US | disclosed |
| US-11730762-B2 | Methods for stimulating proliferation or differentiation of an immune cell with a multi-chain chimeric polypeptide | HCW Biologics, Inc. (US) | 2023-08-22 | — | — | US | disclosed |
| CN-116569844-A | Tissue culture rapid propagation method for inducing cluster buds by utilizing stem sections of ginseng tylophora | 云南省农业科学院药用植物研究所 | 2023-08-11 | — | — | CN | disclosed |
| US-20230233538-A1 | COMPOSITION FOR TREATING CORONAVIRUS DISEASE-19, COMPRISING PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID DERIVATIVES, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS ACTIVE INGREDIENT | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-07-27 | — | — | US | disclosed |
| EP-4205742-A1 | COMPOSITION FOR TREATING CORONAVIRUS-19 INFECTION, COMPRISING PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID DERIVATIVE, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT | Seoul National University R & DB Foundation (KR) | 2023-07-05 | — | — | EP | disclosed |
| WO-2023121486-A1 | COMPOSITIONS AND COMPOUNDS FOR TREATING COVID-19 | INTERNATIONAL PATENT HOLDINGS LLC (KN) | 2023-06-29 | — | — | WO | disclosed |
| US-11672826-B2 | Methods of treating aging-related disorders | HCW Biologics, Inc. (US) | 2023-06-13 | — | — | US | disclosed |
| CN-111303132-B | Anticancer compound and preparation method and application thereof | 辽宁孚音生物科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-111269222-B | Compound and preparation method and application thereof | 辽宁孚音生物科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| US-20230125173-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES | HCW Biologics, Inc. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230128292-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2023-04-27 | — | — | US | disclosed |
| WO-2023052310-A1 | COMPOSITION COMPRISING HESPERIDIN, CITRAL AND A FILM-FORMING SUBSTANCE FOR PROPHYLAXIS OF INFECTIONS | MSV PHARMA GMBH (DE) | 2023-04-06 | — | — | WO | disclosed |
| EP-4157460-A1 | METHODS OF TREATING AGING-RELATED DISORDERS | HCW Biologics, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| EP-4159208-A1 | COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS OF AN INFECTION | MVS Pharma GmbH (DE) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023019215-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES | HCW Biologics, Inc. (US) | 2023-02-16 | — | — | WO | disclosed |
| US-20230039157-A1 | SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2023-02-09 | — | — | US | disclosed |
| US-20230023389-A1 | SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2023-01-26 | — | — | US | disclosed |
| US-11548891-B1 | Quaternary ammonium salts of phenanthroindolizidine and phenanthroquinolizidine alkaloids as hypoxia-targeted anticancer agents | BATTERJEE MEDICAL COLLEGE (SA) | 2023-01-10 | — | — | US | disclosed |
| EP-4103601-A2 | METHODS OF TREATING AGE-RELATED AND INFLAMMATORY DISEASES | HCW Biologics, Inc. (US) | 2022-12-21 | — | — | EP | disclosed |
| EP-4103599-A1 | METHODS OF ACTIVATING REGULATORY T CELLS | HCW Biologics, Inc. (US) | 2022-12-21 | — | — | EP | disclosed |
| US-11518792-B2 | Multi-chain chimeric polypeptides and uses thereof | HCW Biologics, Inc. (US) | 2022-12-06 | — | — | US | disclosed |
| CN-115380045-A | Method for activating regulatory T cells | HCW生物科技公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113135987-B | Active peptides derived from Caprin1 and application thereof | 浙江师范大学 | 2022-07-12 | — | — | CN | disclosed |
| CN-114617909-A | New anti-aging application of tylophora yunnanensis | 华东理工大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-114409649-A | Method for synthesizing indolizidine alkaloid | 安阳师范学院 | 2022-04-29 | — | — | CN | disclosed |
| EP-3987010-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| US-20220105017-A1 | TOPICAL MACQUI BERRY FORMULATION | TRACIE MARTYN INT INC (US) | 2022-04-07 | — | — | US | disclosed |
| CN-114269903-A | Multi-chain chimeric polypeptides and uses thereof | HCW生物科技公司 | 2022-04-01 | — | — | CN | disclosed |
| US-11266675-B2 | Methods of treatment of viral infection and uses of anti-HSC70 inhibitors | CITY UNIVERSITY OF HONG KONG (HK) | 2022-03-08 | — | — | US | disclosed |
| CN-110177527-B | Device and method for adjusting insertion depth of needle for medicament delivery | 科尼尔赛德生物医学公司 | 2022-02-01 | — | — | CN | disclosed |
| US-20220008399-A1 | INHIBITORS OF POSITIVE STRAND RNA VIRUSES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-01-13 | — | — | US | disclosed |
| US-20220008399-A1 | INHIBITORS OF POSITIVE STRAND RNA VIRUSES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-01-13 | — | — | US | disclosed |
| US-20210338724-A1 | METHODS OF TREATING AGE-RELATED AND INFLAMMATORY DISEASES | IMMUNITYBIO, INC. | 2021-11-04 | — | — | US | disclosed |
| CN-113365663-A | Single-chain chimeric polypeptides and uses thereof | HCW生物科技公司 | 2021-09-07 | — | — | CN | disclosed |
| WO-2021163369-A2 | METHODS OF TREATING AGE-RELATED AND INFLAMMATORY DISEASES | HCW Biologics, Inc. (US) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021163298-A1 | METHODS OF ACTIVATING REGULATORY T CELLS | HCW Biologics, Inc. (US) | 2021-08-19 | — | — | WO | disclosed |
| CN-113135987-A | Active peptides derived from Caprin1 and application thereof | 浙江师范大学 | 2021-07-20 | — | — | CN | disclosed |
| EP-3843788-A1 | SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3844182-A1 | SINGLE-CHAIN AND MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3843756-A2 | METHODS OF TREATING AGING-RELATED DISORDERS | HCW Biologics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3844181-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| CN-109422742-B | 9-substituted tylophorine derivative, preparation thereof and application thereof in activity of resisting tobacco mosaic virus | 南开大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-113015744-A | Single-chain chimeric polypeptide and multi-chain chimeric polypeptide and application thereof | HCW生物科技公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-112996805-A | Multi-chain chimeric polypeptides and uses thereof | HCW生物科技公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-112888445-A | Methods of treating conditions associated with aging | HCW生物科技公司 | 2021-06-01 | — | — | CN | disclosed |
| US-20210137981-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-05-13 | — | — | US | disclosed |
| US-10993897-B2 | Topical macqui berry formula | Tracie Martyn International, Inc. (US) | 2021-05-04 | — | — | US | disclosed |
| US-20210100840-A1 | SINGLE-CHAIN AND MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | IMMUNITYBIO, INC. | 2021-04-08 | — | — | US | disclosed |
| CN-108299433-B | Substituted phenanthrene compounds with spiro structures and preparation method and application thereof | 天津工业大学 | 2021-03-23 | — | — | CN | disclosed |
| US-20210070826-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210070825-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210060064-A1 | METHODS OF TREATING AGING-RELATED DISORDERS | IMMUNITYBIO, INC. | 2021-03-04 | — | — | US | disclosed |
| CN-112133449-A | Method and device for predicting induced hepatotoxicity, computer equipment and storage medium | 中南大学 | 2020-12-25 | — | — | CN | disclosed |
| WO-2020257639-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2020-12-24 | — | — | WO | disclosed |
| CN-108610342-B | Novel aza-polycyclic compound and preparation method and application thereof | 中南大学 | 2020-12-15 | — | — | CN | disclosed |
| CN-110283170-B | Preparation of compound and application of compound in inhibiting growth of various tumor cells | 清华大学 | 2020-11-06 | — | — | CN | disclosed |
| CN-110283170-B | Preparation of compound and application of compound in inhibiting growth of various tumor cells | 清华大学 | 2020-11-06 | — | — | CN | disclosed |
| CN-107266434-B | Phenanthroindolizidine alkaloid 6-position derivative, preparation thereof, plant virus resisting activity and anticancer activity | 南开大学 | 2020-08-07 | — | — | CN | disclosed |
| CN-111303132-A | Anticancer compound and preparation method and application thereof | 天津孚音生物科技发展有限公司 | 2020-06-19 | — | — | CN | disclosed |
| US-20200190174-A1 | SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | IMMUNITYBIO, INC. | 2020-06-18 | — | — | US | disclosed |
| CN-111269222-A | Compound and preparation method and application thereof | 天津孚音生物科技发展有限公司 | 2020-06-12 | — | — | CN | disclosed |
| WO-2020047333-A1 | SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020047299-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020047473-A1 | SINGLE-CHAIN AND MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | HCW Biologics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020047462-A2 | METHODS OF TREATING AGING-RELATED DISORDERS | HCW Biologics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| US-20200071374-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | IMMUNITYBIO, INC. | 2020-03-05 | — | — | US | disclosed |
| US-20190328760-A1 | METHODS OF TREATMENT OF VIRAL INFECTION AND USES OF ANTI-HSC70 INHIBITORS | CITY UNIVERSITY OF HONG KONG (HK) | 2019-10-31 | — | — | US | disclosed |
| WO-2019204471-A1 | TREATMENT OF HEPATITIS C | YALE UNIVERSITY (US) | 2019-10-24 | — | — | WO | disclosed |
| CN-110283170-A | A kind of compound preparation and its application in inhibition kinds of tumor cells growth | 清华大学 | 2019-09-27 | — | — | CN | disclosed |
| CN-110283170-A | A kind of compound preparation and its application in inhibition kinds of tumor cells growth | 清华大学 | 2019-09-27 | — | — | CN | disclosed |
| CN-107445956-B | A kind of fully synthetic new method of 13a- hydroxyl tylophorine | 南开大学 | 2019-07-26 | — | — | CN | disclosed |
| US-20190151227-A1 | TOPICAL MACQUI BERRY FORMULA | TRACIE MARTYN INT INC (US) | 2019-05-23 | — | — | US | disclosed |
| CN-106748820-B | A kind of luxuriant and rich with fragrance methyl aminated compounds of substitution and its synthetic method | 天津工业大学 | 2019-04-19 | — | — | CN | disclosed |
| CN-109418278-A | Application of the tylophorine dehydrogenation derivative in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109418278-A | Application of the tylophorine dehydrogenation derivative in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109418278-A | Application of the tylophorine dehydrogenation derivative in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422742-A | 9 tylophorine derivatives replaced and its preparation and the application in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422742-A | 9 tylophorine derivatives replaced and its preparation and the application in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-109422742-A | 9 tylophorine derivatives replaced and its preparation and the application in activity of resisting tobacco mosaic virus | 南开大学 | 2019-03-05 | — | — | CN | disclosed |
| CN-108610342-A | A kind of novel azepine and polycyclic compound and its preparation method and application | 中南大学 | 2018-10-02 | — | — | CN | disclosed |
| CN-108299433-A | One kind carries the substitution phenanthrene class compound and its preparation method and application of spirane structure | 天津工业大学 | 2018-07-20 | — | — | CN | disclosed |
| WO-2018104172-A1 | COMPOUNDS FOR TREATING BARTH SYNDROME | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-06-14 | — | — | WO | disclosed |
| CN-107915547-A | A kind of radix tylophorae plantation special fertilizer and preparation method | 融安县飞煌原生草药材专业合作社 | 2018-04-17 | — | — | CN | disclosed |
| CN-107896841-A | A kind of implantation methods of radix tylophorae | 融安县飞煌原生草药材专业合作社 | 2018-04-13 | — | — | CN | disclosed |
| CN-107864857-A | A kind of inducing culture of radix tylophorae tissue cultures | 融安县飞煌原生草药材专业合作社 | 2018-04-03 | — | — | CN | disclosed |
| CN-107864814-A | A kind of method for improving radix tylophorae percentage of fertile fruit | 融安县飞煌原生草药材专业合作社 | 2018-04-03 | — | — | CN | disclosed |
| CN-107793220-A | A kind of nutrient solution for improving radix tylophorae Pollen Activity | 融安县飞煌原生草药材专业合作社 | 2018-03-13 | — | — | CN | disclosed |
| CN-107711501-A | A kind of tissue culture and rapid propagation method of radix tylophorae | 融安县飞煌原生草药材专业合作社 | 2018-02-23 | — | — | CN | disclosed |
| CN-107691127-A | A kind of radix tylophorae root media and preparation method | 融安县飞煌原生草药材专业合作社 | 2018-02-16 | — | — | CN | disclosed |
| CN-107445956-A | A kind of fully synthetic new method of 13a hydroxyls tylophorine | 南开大学 | 2017-12-08 | — | — | CN | disclosed |
| CN-107266434-A | Phenanthroindolizididerivative pyridine alkaloid 6- bit derivants and its preparation, Antiphytoviral, active anticancer | 南开大学 | 2017-10-20 | — | — | CN | disclosed |
| CN-105130985-B | Phenanthroindolizididerivative pyridine alkaloid quaternary ammonium salt derivatives and its preparation and Antiphytoviral application | 南开大学 | 2017-08-25 | — | — | CN | disclosed |
| CN-107011043-A | A kind of tobacco disease resistance foliar fertilizer | 四川省烟草公司泸州市公司 | 2017-08-04 | — | — | CN | disclosed |
| US-9708310-B2 | Phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof, preparation method and use thereof | CHINA MEDICAL UNIVERSITY (TW) | 2017-07-18 | — | — | US | disclosed |
| CN-104497077-B | The extraction separation method of chromone ketoside compounds and the application in easing pain and diminishing inflammation medicine is prepared | 广东省中药研究所 | 2017-06-27 | — | — | CN | disclosed |
| CN-106866662-A | A kind of luxuriant and rich with fragrance a pair of horses going side by side Indolizidine alkaloid and preparation method thereof | 江西农业大学 | 2017-06-20 | — | — | CN | disclosed |
| CN-105394058-B | Two optically pure isomers and its germicidal applications of NK007 | 南开大学 | 2017-06-16 | — | — | CN | disclosed |
| US-20170152257-A1 | PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID HAVING A HYDROXYL GROUP ON THE PHENANTHRENE RING THEREOF, PREPARATION METHOD AND USE THEREOF | CHINA MEDICAL UNIVERSITY (TW) | 2017-06-01 | — | — | US | disclosed |
| CN-106748820-A | The luxuriant and rich with fragrance methyl aminated compounds of one kind substitution and its synthetic method | 天津工业大学 | 2017-05-31 | — | — | CN | disclosed |
| WO-2017050262-A1 | PHENANTHROINDOLIZIDINE ALKALOID QUATERNARY AMMONIUM SALT DERIVATIVES, AND PREPARATION THEREOF AND APPLICATION THEREOF IN RESISTANCE TO PLANT VIRUSES | 南开大学 | 2017-03-30 | — | — | WO | disclosed |
| CN-105461716-B | Two NK007 optical pure isomers and synthesis and application thereof | 南开大学 | 2017-03-22 | — | — | CN | disclosed |
| CN-106478589-A | Tylophorine contains trifluoromethyl derivative and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478589-A | Tylophorine contains trifluoromethyl derivative and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478589-A | Tylophorine contains trifluoromethyl derivative and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478590-A | Tylophorine fluorine-containing derivant and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478590-A | Tylophorine fluorine-containing derivant and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478590-A | Tylophorine fluorine-containing derivant and preparation method thereof | 上海药明康德新药开发有限公司 | 2017-03-08 | — | — | CN | disclosed |
| US-20170027853-A1 | TOPICAL MACQUI BERRY FORMULATION | TRACIE MARTYN INTERNATIONAL, LLC | 2017-02-02 | — | — | US | disclosed |
| CN-103965091-B | The preparation of 2-(2,3,6,7-tetramethoxy-9-phenanthrene methyl) pyrroles | 江苏蓝丰生物化工股份有限公司 | 2016-12-28 | — | — | CN | disclosed |
| CN-106166167-A | The preparation method of a kind of tylophora alkaloids extract and detection method thereof | 广西慧宝源制药有限公司 | 2016-11-30 | — | — | CN | disclosed |
| CN-106061496-A | Cd44 binding peptides | 交换成像技术股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| US-9463153-B2 | Topical macqui berry formulation | Trade Martyn International, LLC (US) | 2016-10-11 | — | — | US | disclosed |
| CN-105796622-A | Tylophora total alkaloids purification method and application thereof | 广西慧宝源制药有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105532453-A | Two-step culturing method for seeding formation tissue of Tylophora kerrii | GUANGXI BOTANICAL GARDEN MEDICINAL PLANTS | 2016-05-04 | — | — | CN | disclosed |
| CN-105461716-A | Two NK007 optical pure isomers and synthesis and application thereof | UNIV NANKAI | 2016-04-06 | — | — | CN | disclosed |
| CN-105169031-A | Medicament for treating heatstroke and preparation method of medicament | ZHANG SHIHAI | 2015-12-23 | — | — | CN | disclosed |
| US-9216977-B2 | Antofine and cryptopleurine derivatives as anticancer agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2015-12-22 | — | — | US | disclosed |
| CN-103509012-B | Phenanthroindolizididerivative pyridine alkaloid C14 position amination derivative and preparation thereof and anti-phytoviral activity | NANKAI UNIVERSITY (CN) | 2015-12-16 | — | — | CN | disclosed |
| CN-105130985-A | Phenanthroindolizidine alkaloid quaternary ammonium salt derivative and preparation and plant virus resisting application thereof | UNIV NANKAI | 2015-12-09 | — | — | CN | disclosed |
| CN-105106700-A | Composition for treating heat stroke and preparation method of composition | ZHANG SHIHAI | 2015-12-02 | — | — | CN | disclosed |
| CN-103130806-B | The inner western pyridine alcaloid-derivatives of phenanthro-indoles (quinoline) and preparation, anti-TMV activity, HIV (human immunodeficiency virus)-resistant activity and antitumour activity | NANKAI UNIVERSITY (CN) | 2015-11-25 | — | — | CN | disclosed |
| CN-105037357-A | Phenanthroindolizidine compound and NF kB inhibitor containing same as active ingredient | YAKULT HONSHA KK | 2015-11-11 | — | — | CN | disclosed |
| US-9174979-B2 | Phenanthroindolizidine compound and NFκB inhibitor containing same as active ingredient | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2015-11-03 | — | — | US | disclosed |
| CN-104840840-A | Traditional Chinese medicine external lotion for treating calcaneodynia and preparation method | LI NIANHU | 2015-08-19 | — | — | CN | disclosed |
| EP-2351754-B1 | PHENANTHROINDOLIZIDINE COMPOUND AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | YAKULT HONSHA KK (JP) | 2015-06-24 | — | — | EP | disclosed |
| US-20150150770-A1 | METHODS OF TREATING SKIN | TRACIE MARTYN INTERNATIONAL INC (US) | 2015-06-04 | — | — | US | disclosed |
| CN-104547662-A | Preparation for clearing away heart fire for resuscitation, nourishing yin and promoting generation of body fluid for acute infantile convulsion and preparation method of preparation | HAO GUIHUA | 2015-04-29 | — | — | CN | disclosed |
| CN-104491347-A | Acupuncture point paste for treating acute infantile convulsions and preparation method of acupuncture point paste | HAO GUIHUA | 2015-04-08 | — | — | CN | disclosed |
| CN-104497077-A | Extraction separation method of chromone glycoside compound and application of chromone glycoside compound in preparation of analgesic anti-inflammatory medicine | GUANGDONG TRADITIONAL CHINESE MEDICINE RES INST | 2015-04-08 | — | — | CN | disclosed |
| EP-2351753-B1 | PHENANTHROINDOLIZIDINE DERIVATIVE AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | YAKULT HONSHA KK (JP) | 2015-02-11 | — | — | EP | disclosed |
| CN-104258238-A | External application path for fracture patients and preparation method thereof | ZHANG XIANGCAI | 2015-01-07 | — | — | CN | disclosed |
| CN-104258239-A | Orthopedic postoperative blood-activating recovery drug and preparation method thereof | ZHANG XIANGCAI | 2015-01-07 | — | — | CN | disclosed |
| US-20140377338-A1 | TOPICAL MACQUI BERRY FORMULATION | TRACIE MARTYN INTERNATIONAL, LLC | 2014-12-25 | — | — | US | disclosed |
| CN-102186850-B | Phenanthroindolizidine derivative and nfkb inhibitor containing same as active ingredient | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2014-10-29 | — | — | CN | disclosed |
| US-8828458-B2 | Topical macqui berry formulation | TRACIE MARTYN INTERNATIONAL, LLC | 2014-09-09 | — | — | US | disclosed |
| CN-103965091-A | Preparation of 2-(2,3,6,7-tetramethoxy-9-phenanthrmethylmethyl)pyrrole | JIANGSU LANFENG BIOCHEMICAL CO LTD | 2014-08-06 | — | — | CN | disclosed |
| CN-103960229-A | Tylophorine malate (NK-007) water aqua and preparation method thereof, and application of tylophorine malate water aqua in prevention and treatment of viral diseases of tobacco, capsicum and tomatoes | JIANGSU LANFENG BIOCHEMICAL CO LTD | 2014-08-06 | — | — | CN | disclosed |
| CN-103960230-A | Tylophorine malate (NK-007) microemulsion and preparation method thereof, and application of tylophorine malate microemulsion in prevention and treatment of viral diseases of tobacco | JIANGSU LANFENG BIOCHEMICAL CO LTD | 2014-08-06 | — | — | CN | disclosed |
| US-20140155961-A1 | METHODS OF TREATING SKIN | Tracie Martyn International, Inc. (US) | 2014-06-05 | — | — | US | disclosed |
| US-8658605-B2 | Bioactivity composition of Reevesia formosana | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2014-02-25 | — | — | US | disclosed |
| EP-2429997-B1 | 2-AZATRIPHENYLENE MATERIALS FOR ORGANIC LIGHT EMITTING DIODES | UNIVERSAL DISPLAY CORP (US) | 2014-01-15 | — | — | EP | disclosed |
| CN-103509012-A | Phenanthroindolizidine alkaloid C14-site aminated derivatives, and preparation and anti-plant virus activity thereof | UNIV NANKAI | 2014-01-15 | — | — | CN | disclosed |
| US-8569327-B2 | Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-10-29 | — | — | US | disclosed |
| EP-2633884-A1 | Obesity small molecules | Akron Molecules GmbH (AT) | 2013-09-04 | — | — | EP | disclosed |
| CN-101899043-B | Tylophora ovata base analogs with anti-tumor activity and preparation method and use thereof | UNIV NANJING SCIENCE & TECH | 2013-06-05 | — | — | CN | disclosed |
| CN-103130806-A | Phenanthroindo(quio)lizidine alkaloid derivative, and preparation, anti-TMV activity, anti-HIV activity and anti-tumor activity thereof | UNIV NANKAI | 2013-06-05 | — | — | CN | disclosed |
| CN-101953864-B | Cynanchum otophyllum aglycone and medical application of extractive containing same | INST PHARM & TOXICOLOGY AMMS | 2013-05-22 | — | — | CN | disclosed |
| US-8440649-B2 | Phenanthroindolizidine analogues | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-05-14 | — | — | US | disclosed |
| US-8440649-B2 | Phenanthroindolizidine analogues | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-05-14 | — | — | US | disclosed |
| US-20130030007-A1 | Obesity Small Molecules | AKRON MOLECULES GMBH (AT) | 2013-01-31 | — | — | US | disclosed |
| CN-102827163-A | Method for extracting tylophorine from tylophora florlbunda | NANJING ZHENGLIANG MED TECH CO | 2012-12-19 | — | — | CN | disclosed |
| CN-102827163-A | Method for extracting tylophorine from tylophora florlbunda | NANJING ZHENGLIANG MED TECH CO | 2012-12-19 | — | — | CN | disclosed |
| CN-102827163-A | Method for extracting tylophorine from tylophora florlbunda | NANJING ZHENGLIANG MED TECH CO | 2012-12-19 | — | — | CN | disclosed |
| EP-2521594-A2 | OBESITY SMALL MOLECULES | Akron Molecules GmbH (AT) | 2012-11-14 | — | — | EP | disclosed |
| US-20120283220-A1 | ANTOFINE AND CRYPTOPLEURINE DERIVATIVES AS ANTICANCER AGENTS | NIH-DEITR | 2012-11-08 | — | — | US | disclosed |
| US-20120258923-A1 | BIOACTIVITY COMPOSITION OF Reevesia formosana | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-10-11 | — | — | US | disclosed |
| CN-102626432-A | Method for extracting alkaloid from tylophora | NANJING ZELANG MEDICAL TECH CO | 2012-08-08 | — | — | CN | disclosed |
| US-8188089-B2 | Tylophorine analogs as antitumor agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188089-B2 | Tylophorine analogs as antitumor agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-20120114719-A1 | Topical Macqui Berry Formulation | TRACIE MARTYN INTERNATIONAL, LLC (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120029018-A1 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-02 | — | — | US | disclosed |
| US-20120029018-A1 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-02 | — | — | US | disclosed |
| CN-101138612-B | Antineoplastic preparations and method of preparing the same | GUILIN SHANGYUAN PLANT PRODUCT CO., LTD. (CN) | 2011-12-07 | — | — | CN | disclosed |
| CN-102186849-A | Phenanthroindolizidine compounds and NF κ B inhibitors containing the same as active ingredient | YAKULT HONSHA KK | 2011-09-14 | — | — | CN | disclosed |
| CN-102186850-A | Phenanthroindolizidine derivative and nfkb inhibitor containing same as active ingredient | YAKULT HONSHA KK | 2011-09-14 | — | — | CN | disclosed |
| US-20110201637-A1 | PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-08-18 | — | — | US | disclosed |
| US-20110201638-A1 | PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-08-18 | — | — | US | disclosed |
| EP-2351753-A1 | PHENANTHROINDOLIZIDINE DERIVATIVE AND NF B INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | Kabushiki Kaisha Yakult Honsha (JP) | 2011-08-03 | — | — | EP | disclosed |
| EP-2351754-A1 | PHENANTHROINDOLIZIDINE COMPOUND AND NF B INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | Kabushiki Kaisha Yakult Honsha (JP) | 2011-08-03 | — | — | EP | disclosed |
| WO-2011083150-A2 | OBESITY SMALL MOLECULES | AKRON MOLECULES GMBH (AT) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011049704-A1 | ANTOFINE AND CRYPTOPLEURINE DERIVATIVES AS ANTICANCER AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-04-28 | — | — | WO | disclosed |
| CN-101953864-A | Cynanchum otophyllum aglycone and medical application of extractive containing same | INST PHARM & TOXICOLOGY AMMS | 2011-01-26 | — | — | CN | disclosed |
| CN-101899043-A | Tylophora ovata base analogs with anti-tumor activity and preparation method and use thereof | UNIV NANJING SCIENCE & TECH | 2010-12-01 | — | — | CN | disclosed |
| CN-101875657-A | Application of tylophorine-type alkaloid organic acidic salt derivatives in pesticide | UNIV NANKAI | 2010-11-03 | — | — | CN | disclosed |
| US-20100272790-A1 | Methods of Treating Skin | TRACIE MARTYN INTERNATIONAL, LLC (US) | 2010-10-28 | — | — | US | disclosed |
| US-20100216773-A1 | PHENANTHROINDOLIZIDINE ANALOGUES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-08-26 | — | — | US | disclosed |
| US-20100216773-A1 | PHENANTHROINDOLIZIDINE ANALOGUES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-08-26 | — | — | US | disclosed |
| US-7776915-B2 | Topical formulations and methods of use | TRACIE MARTYN INTERNATIONAL, LLC (US) | 2010-08-17 | — | — | US | disclosed |
| WO-2010027424-A3 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-06-03 | — | — | WO | disclosed |
| WO-2010027424-A2 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010027424-A2 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-03-11 | — | — | WO | disclosed |
| CN-100586286-C | Plant antiviral agent, preparation method and application thereof | YUCHENG YAO | 2010-02-03 | — | — | CN | disclosed |
| EP-1968975-A4 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1968975-A4 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20080300254-A1 | Tylophorine Analogs as Antitumor Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| US-20080300254-A1 | Tylophorine Analogs as Antitumor Agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| EP-1968975-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1968975-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2008-09-17 | — | — | EP | disclosed |
| CN-101138612-A | Antineoplastic preparations and method of preparing the same | BEIJING WEIMINGBAO BIOLOG TECH (CN) | 2008-03-12 | — | — | CN | disclosed |
| CN-101084761-A | Plant antiviral agent, preparation method and application thereof | YUCHENG YAO (CN) | 2007-12-12 | — | — | CN | disclosed |
| WO-2007081540-A3 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007081540-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007081540-A2 | TYLOPHORINE ANALOGS AS ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007046113-A2 | NOVEL PHARMACEUTICAL COMPOSITION COMPRISING ALKALOID AND PROCESS THEREOF | PANACEA BIOTEC LTD. (IN) | 2007-04-26 | — | — | WO | disclosed |
| US-20070065396-A1 | Topical macqui berry formulation | TRACIE MARTYN INTERNATIONAL, LLC | 2007-03-22 | — | — | US | disclosed |
| EP-1482937-A4 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | UNIV YALE (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20060216251-A1 | Topical formulations and methods of use | TRACIE MARTYN INTERNATIONAL, LLC (US) | 2006-09-28 | — | — | US | disclosed |
| WO-2006003676-A1 | A NOVEL METHOD TO INHIBIT INFLAMMATION AND TUMOR GROWTH BY TYLOPHORA ALKALOIDS | SECRETARY, DEPARTMENT OF ATOMIC ENERGY (IN) | 2006-01-12 | — | — | WO | disclosed |
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-06 | — | — | US | disclosed |
| EP-1482937-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2004-12-08 | — | — | EP | disclosed |
| CN-1156475-C | Cynanchun Komarovii extract and its application | 南开大学 | 2004-07-07 | — | — | CN | disclosed |
| WO-2003070166-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2003-08-28 | — | — | WO | disclosed |
| CN-1321642-A | Cynanchun komarovii extract and its application | UNIV NANKAI (CN) | 2001-11-14 | — | — | CN | disclosed |
| CN-1035057-C | Method of preventing polymer scale formation | SHINETSU CHEMICAL CO (JP) | 1997-06-04 | — | — | CN | disclosed |
| US-4970212-A | ADMINISTERING CYTOSTATIC ALKALOIDS EXTRACTED FROM PLANTS | NOWICKY WASSILI (AT) | 1990-11-13 | — | — | US | disclosed |
| CN-1040206-A | Prevent to form the method for polymer scale formation | SHINETSU CHEMICAL CO (JP) | 1990-03-07 | — | — | CN | disclosed |
| US-4816462-A | ANTITUMOR AGENTS, FLUORESCENCE | NOWICKY WASSILI (AT) | 1989-03-28 | — | — | US | disclosed |
| US-4816462-A | ANTITUMOR AGENTS, FLUORESCENCE | NOWICKY WASSILI (AT) | 1989-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (27 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132561-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-11548891-B1 | Quaternary ammonium salts of phenanthroindolizidine and phenanthroquinolizidine alkaloids as hypoxia-targeted anticancer agents | H1-3, H1-4, H1-2 | HIF1A 8/4885EPAS1 1860/4885JUN 2264/4885 |
| US-20200071374-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-20170152257-A1 | PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID HAVING A HYDROXYL GROUP ON THE PHENANTHRENE RING THEREOF, PREPARATION METHOD AND USE THEREOF | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, PAH, HIPK4 | HIF1A 487/4885EPAS1 592/4885JUN 2252/4885 |
| US-20140155961-A1 | METHODS OF TREATING SKIN | CUTA, LIPA, DLAT | HIF1A 1922/4885EPAS1 1493/4885JUN 3920/4885 |
| US-20100272790-A1 | Methods of Treating Skin | CUTA, LIPA, DLAT | HIF1A 1922/4885EPAS1 1493/4885JUN 3920/4885 |
| US-11957667-B2 | Inhibitors of positive strand RNA viruses | EIF2AK2, POLRMT, NSUN3 | HIF1A 1661/4885EPAS1 2985/4885JUN 3784/4885 |
| US-20210060064-A1 | METHODS OF TREATING AGING-RELATED DISORDERS | GLA, GZMB, TSLP | HIF1A 1131/4885EPAS1 3710/4885JUN 807/4885 |
| US-11518792-B2 | Multi-chain chimeric polypeptides and uses thereof | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-20220008399-A1 | INHIBITORS OF POSITIVE STRAND RNA VIRUSES | EIF2AK2, POLRMT, NSUN3 | HIF1A 1661/4885EPAS1 2985/4885JUN 3784/4885 |
| US-20150150770-A1 | METHODS OF TREATING SKIN | CUTA, LIPA, DLAT | HIF1A 1922/4885EPAS1 1493/4885JUN 3920/4885 |
| US-20210070825-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-11672826-B2 | Methods of treating aging-related disorders | GLA, GZMB, TSLP | HIF1A 1131/4885EPAS1 3710/4885JUN 807/4885 |
| US-20240124543-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-20230128292-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
| US-20240033256-A1 | INHIBITORS OF POSITIVE STRAND RNA VIRUSES | POLRMT, EIF2AK2, NSUN3 | HIF1A 1447/4885EPAS1 2860/4885JUN 3522/4885 |
| US-20110201638-A1 | PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | NFKBIA, NFKB2, NFKB1 | HIF1A 1332/4885EPAS1 2353/4885JUN 118/4885 |
| US-20120258923-A1 | BIOACTIVITY COMPOSITION OF Reevesia formosana | RPS7, RPS10, RPS20 | HIF1A 3930/4885EPAS1 3962/4885JUN 3145/4885 |
| US-20060216251-A1 | Topical formulations and methods of use | CPT1B, SLC25A20, CPT1A | HIF1A 1311/4885EPAS1 1047/4885JUN 4118/4885 |
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | IRF3, ILF3, ATL3 | HIF1A 3833/4885EPAS1 3827/4885JUN 2439/4885 |
| US-20120283220-A1 | ANTOFINE AND CRYPTOPLEURINE DERIVATIVES AS ANTICANCER AGENTS | XPO5, TYMP, CA5A | HIF1A 1409/4885EPAS1 2295/4885JUN 4522/4885 |
| US-20080300254-A1 | Tylophorine Analogs as Antitumor Agents | RPL30, RPL18A, RPP30 | HIF1A 3670/4885EPAS1 4609/4885JUN 4504/4885 |
| US-20110201637-A1 | PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | NFKBIA, NFKB2, NFKB1 | HIF1A 1335/4885EPAS1 2130/4885JUN 113/4885 |
| US-20120029018-A1 | 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES | ABCB1, TYMP, PAH | HIF1A 869/4885EPAS1 4051/4885JUN 2549/4885 |
| US-20230233538-A1 | COMPOSITION FOR TREATING CORONAVIRUS DISEASE-19, COMPRISING PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID DERIVATIVES, OPTICAL ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS ACTIVE INGREDIENT | ACE, ACE2, DPP9 | HIF1A 724/4885EPAS1 1744/4885JUN 2719/4885 |
| US-20100216773-A1 | PHENANTHROINDOLIZIDINE ANALOGUES | DPP4, PAH, ACE | HIF1A 562/4885EPAS1 702/4885JUN 1076/4885 |
| US-20210070826-A1 | MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF | TNFSF11, HDGF, CD2BP2 | HIF1A 1549/4885EPAS1 764/4885JUN 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.