Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247031 | 0.93 | LMNA (0.41) | LMNAMETRECQLTP53ALDH1A1 | |
| SCHEMBL5245990 | 0.90 | P2RX7 (0.42) | LMNADDR1CYP1A2CYP2C19P2RX7 | |
| SCHEMBL5247254 | 0.89 | HPGD (0.44) | LMNAROCK2RECQLTP53ALDH1A1 | |
| SCHEMBL5244456 | 0.87 | LMNA (0.57) | LMNAALDH1A1MIFMAPT | |
| SCHEMBL5245295 | 0.86 | LMNA (0.44) | LMNAROCK2METROCK1RECQL | |
| SCHEMBL5249308 | 0.86 | RIPK1 (0.46) | LMNAROCK2ROCK1RECQLALDH1A1 | |
| SCHEMBL5244366 | 0.86 | CCR1 (0.45) | LMNAROCK2TP53ALDH1A1MAPT | |
| SCHEMBL5250067 | 0.86 | P2RX7 (0.39) | LMNAMETRECQLTP53ALDH1A1 | |
| SCHEMBL5249047 | 0.85 | LMNA (0.38) | LMNAROCK2ROCK1RECQLTP53 | |
| SCHEMBL5247403 | 0.84 | LMNA (0.39) | LMNAROCK2ROCK1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |