Sugi Predict

Sugi Predict / Compounds / SCHEMBL5280067

SCHEMBL5280067

SCHEMBL5280067

Cc1cc(C)c2[nH]c(=O)oc(=O)c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ GRIN2D O15399 1/20 0.44
▸ GRIN3B O60391 1/20 0.44
▸ GRIN1 Q05586 1/20 0.44
▸ GRIN2A Q12879 1/20 0.44
▸ GRIN2B Q13224 1/20 0.44
▸ GRIN2C Q14957 1/20 0.44
▸ GRIN3A Q8TCU5 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ ESR1 P03372 2/20 0.40
▸ ESR2 Q92731 2/20 0.40
▸ F2 P00734 1/20 0.39
▸ CFD P00746 1/20 0.39
▸ PARP1 P09874 2/20 0.39
▸ DAO P14920 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ MAOA P21397 1/20 0.38
▸ MAOB P27338 1/20 0.38
▸ NOS1 P29475 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21751078 0.82 ALDH1A1 (0.47) MAPTESR1ESR2F2CFD
SCHEMBL17767227 0.82 F2 (0.37) ABCB1MAPTGRIN2DGRIN3BGRIN1
SCHEMBL14698434 0.82 F2 (0.37) ABCB1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL30087001 0.82 LMNA (0.38) MAPTF2CFDSMN1; SMN2MAOA
SCHEMBL13208799 0.82 F2 (0.37) ABCB1MAPTGRIN2DGRIN3BGRIN1
SCHEMBL3208633 0.82 GSK3B (0.38) ABCB1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2906293 0.82 F2 (0.37) ABCB1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL634152 0.82 LMNA (0.38) MAPTF2CFDSMN1; SMN2MAOA
SCHEMBL2904782 0.78 NOS3 (0.40) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL17303417 0.78 MAOA (0.36) F2CFDMAOAMAOBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023211977-A1 TRYPTANTHRIN DERIVATIVES AND USES THEREOF VISCIENT BIO, INC. (US) 2023-11-02 — — WO disclosed
CN-112062730-B 4-oxo-3, 4-dihydro-1, 2, 3-benzotriazines as modulators of GPR139 武田药品工业株式会社 2023-09-29 — — CN disclosed
US-11173161-B2 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-11-16 — — US disclosed
EP-3536324-B1 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINES AS MODULATORS OF GPR139 TAKEDA PHARMACEUTICALS CO (JP) 2021-10-06 — — EP disclosed
CN-112062730-A 4-oxo-3, 4-dihydro-1, 2, 3-benzotriazines as modulators of GPR139 武田药品工业株式会社 2020-12-11 — — CN disclosed
CN-107108531-B 4-oxo-3, 4-dihydro-1, 2, 3-benzotriazines as modulators of GPR139 武田药品工业株式会社 2020-10-20 — — CN disclosed
US-20200129518-A1 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE MODULATORS OF GPR139 TAKEDA CALIFORNIA, INC. 2020-04-30 — — US disclosed
US-10561662-B2 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-02-18 — — US disclosed
EP-3536324-A1 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINES AS MODULATORS OF GPR139 Takeda Pharmaceutical Company Limited (JP) 2019-09-11 — — EP disclosed
EP-3221298-B1 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE DERIVATIVES AS MODULATORS OF GPR139 TAKEDA PHARMACEUTICALS CO (JP) 2019-04-03 — — EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
CN-101535276-A 2, 4-diaminopyrimidine fused bicyclic derivatives as ALK and c-MET inhibitors CEPHALON INC (US) 2009-09-16 — — CN disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
US-20090104145-A1 Mixtures of Anthranilamide Invertebrate Pest Control Agents E. I. DU PONT DE NEMOURS AND COMPANY 2009-04-23 — — US disclosed
EP-0918754-B1 ANTHRANILIC ACID DIAMIDES DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE AS ANTI-GASTRIN AGENTS ROTTAPHARM SPA (IT) 2007-12-05 — — EP disclosed
US-6075033-A Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents ROTTA RESEARCH LABORATORIUM S.P.A (IT) 2000-06-13 — — US disclosed
US-5441955-A Tuberculosis PATHOGENESIS CORPORATION (US) 1995-08-15 — — US disclosed
WO-1995013807-A1 INDOLO[2,1-b]QUINAZOLINE-6,12-DIONE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF PATHOGENESIS CORPORATION (US) 1995-05-26 — — WO disclosed
US-4137325-A Antisecretory oxamic acid esters AMERICAN HOME PRODUCTS CORPORATION (US) 1979-01-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200129518-A1 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE MODULATORS OF GPR139 GPR139, GPR3, GPR84 ABCB1 1343/4885MAPT 3503/4885GRIN2D 717/4885
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 ABCB1 1031/4885MAPT 4535/4885GRIN2D 767/4885
US-20090104145-A1 Mixtures of Anthranilamide Invertebrate Pest Control Agents NME4, NLN, STOM ABCB1 2338/4885MAPT 4815/4885GRIN2D 1674/4885
US-10561662-B2 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 GPR139, GPR3, GPR84 ABCB1 1343/4885MAPT 3503/4885GRIN2D 717/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT ABCB1 629/4885MAPT 3656/4885GRIN2D 1279/4885
US-11173161-B2 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 GPR139, GPR3, GPR84 ABCB1 1343/4885MAPT 3503/4885GRIN2D 717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.