SCHEMBL5369767

SCHEMBL5369767

NNc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1Cl

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
MAPT P10636 1/20 0.33
GAA P10253 3/20 0.32
PLAU P00749 1/20 0.32
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31
KMT2A Q03164 1/20 0.31
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16703446 0.87 ALDH1A1 (0.33) ALDH1A1MAPTGAAPLAUKDM4E
SCHEMBL241686 0.83 ALDH1A1 (0.42) ALDH1A1MAPTGAAPLAUKDM4E
Hydrochloric Acid SCHEMBL5745583 0.81 ALDH1A1 (0.41) ALDH1A1MAPTGAAPLAUKDM4E
SCHEMBL16702836 0.80 AR (0.39) ALDH1A1MAPTGAAPOLBSMN1; SMN2
SCHEMBL22310458 0.79 KMT2A (0.33) ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A
SCHEMBL16703818 0.77 RAPGEF4 (0.36)
SCHEMBL299601 0.76 ALDH1A1 (0.46) ALDH1A1GAAPLAUKDM4EPOLB
Hydrochloric Acid SCHEMBL5352321 0.75 RAPGEF4 (0.35) POLB
SCHEMBL11674968 0.72 ALDH1A1 (0.38) ALDH1A1MAPTGAAPLAUKDM4E
SCHEMBL2835169 0.72 ALDH1A1 (0.38) ALDH1A1MAPTGAAPLAUKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894442-B Substituted benzamide derivative or salt and composition acceptable by pesticides and application thereof 海利尔药业集团股份有限公司 2025-02-14 CN disclosed
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-05-18 US disclosed
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-05-18 US disclosed
CN-115894442-A Substituted benzamide derivative or salt acceptable as pesticide, composition and application thereof 海利尔药业集团股份有限公司 2023-04-04 CN disclosed
US-11490620-B2 Pesticidally active thiophene derivatives SYNGENTA PARTICIPATIONS AG (SE) 2022-11-08 US disclosed
EP-3665170-B1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-09-15 EP disclosed
US-10836732-B2 Compounds for combating arthropods BAYER ANIMAL HEALTH GMBH (DE) 2020-11-17 US disclosed
US-20200245624-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (SE) 2020-08-06 US disclosed
US-20200245624-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (SE) 2020-08-06 US disclosed
EP-3665170-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES Syngenta Participations AG (CH) 2020-06-17 EP disclosed
US-20160297765-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS ELANCO ANIMAL HEALTH GMBH (DE) 2016-10-13 US disclosed
US-20160280668-A1 NOVEL COMPOUNDS FOR COMBATING ARTHROPODS ELANCO ANIMAL HEALTH GMBH (DE) 2016-09-29 US disclosed
US-20160278379-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS ELANCO ANIMAL HEALTH GMBH (DE) 2016-09-29 US disclosed
EP-3066083-A1 NOVEL COMPOUNDS FOR COMBATING ARTHROPODS Bayer CropScience Aktiengesellschaft (DE) 2016-09-14 EP disclosed
CN-105873906-A Novel compounds for controlling arthropods 拜耳作物科学股份公司 2016-08-17 CN disclosed
WO-2015067648-A1 NOVEL COMPOUNDS FOR COMBATING ARTHROPODS BAYER CROPSCIENCE AG (DE) 2015-05-14 WO disclosed
US-7169955-B2 Perfluoroisopropylbenzene derivative NIHON NOHYAKU CO., LTD. (JP) 2007-01-30 US disclosed
US-20050113567-A1 Perfluoroisopropylbenzene derivative NIHON NOHYAKU CO., LTD. (JP) 2005-05-26 US disclosed
US-20030187233-A1 PERFLUOROISOPROPYBENZENE DERIVATIVE NIHON NOHYAKU CO., LTD. (JP) 2003-10-02 US disclosed
EP-1253128-A1 PERFLUOROISOPROPYLBENZENE DERIVATIVES Nihon Nohyaku Co., Ltd. (JP) 2002-10-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200245624-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES ACHE, DDT, GSTP1 ALDH1A1 522/4885MAPT 2764/4885GAA 382/4885
US-20030187233-A1 PERFLUOROISOPROPYBENZENE DERIVATIVE AFF1, CBR1, RER1 ALDH1A1 1079/4885MAPT 4649/4885GAA 4868/4885
US-11490620-B2 Pesticidally active thiophene derivatives ACHE, DDT, GSTP1 ALDH1A1 522/4885MAPT 2764/4885GAA 382/4885
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES ACHE, DDT, GSTP1 ALDH1A1 444/4885MAPT 2448/4885GAA 321/4885
US-10836732-B2 Compounds for combating arthropods PRDX4, SERPINB6, GSTA1 ALDH1A1 238/4885MAPT 4191/4885GAA 1023/4885
US-20160278379-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS CYP4X1, CYP4B1, SERPINB6 ALDH1A1 424/4885MAPT 3991/4885GAA 1592/4885
US-20160280668-A1 NOVEL COMPOUNDS FOR COMBATING ARTHROPODS PRDX4, CYP4X1, PRDX1 ALDH1A1 359/4885MAPT 4049/4885GAA 1577/4885
US-20050113567-A1 Perfluoroisopropylbenzene derivative FFAR3, CBR3, HCAR3 ALDH1A1 2953/4885MAPT 4742/4885GAA 4857/4885
US-20160297765-A1 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS CYP4X1, CYP4B1, SERPINB6 ALDH1A1 424/4885MAPT 3991/4885GAA 1592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.