SCHEMBL537507

SCHEMBL537507

CC(C)C(=O)Nc1nc(O)c2c(n1)[N+]=CN2

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.40
ALDH1A1 P00352 3/20 0.38
LMNA P02545 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ADORA2A P29274 1/20 0.36
TSHR P16473 2/20 0.34
NOS1 P29475 1/20 0.34
CDC7 O00311 1/20 0.33
KDM4E B2RXH2 2/20 0.32
GLA P06280 1/20 0.31
RECQL P46063 1/20 0.31
GAA P10253 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
CCNE1 P24864 1/20 0.30
CDK2 P24941 1/20 0.30
CDK5 Q00535 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8781884 0.84 CYP1A2 (0.38) ADORA1ALDH1A1KDM4E
SCHEMBL8886595 0.75 NOS1 (0.38) ADORA1ALDH1A1LMNAHSD17B10TSHR
SCHEMBL16316425 0.69 ADORA1 (0.56) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL30590049 0.66 ADORA1 (0.41) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL4777464 0.66 ADORA1 (0.41) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL6483424 0.66 ALDH1A1 (0.42) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL4777463 0.65 GDA (0.42) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL10995388 0.64 ADORA1 (0.42) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL537506 0.63 ADORA1 (0.41) ADORA1ALDH1A1LMNAHSD17B10ADORA2A
SCHEMBL20814443 0.61 ADORA1 (0.49) ADORA1ALDH1A1LMNAHSD17B10ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348522-A1 METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-11-02 US claimed
EP-2862868-B1 INTERMEDIATE FOR PRODUCTION OF NUCLEOSIDE ANALOGUE, AND METHOD FOR PRODUCING SAME DAIICHI SANKYO CO LTD (JP) 2020-04-08 EP claimed
EP-1152009-B2 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES DAIICHI SANKYO CO LTD (JP) 2017-09-06 EP claimed
US-9738681-B2 Intermediate for production of nucleoside analog and method for producing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-22 US claimed
US-20160068561-A9 Intermediate for Production of Nucleoside Analog and Method for Producing the Same DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-10 US claimed
US-20150152132-A1 Intermediate for Production of Nucleoside Analog and Method for Producing the Same DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-06-04 US claimed
EP-2862868-A1 INTERMEDIATE FOR PRODUCTION OF NUCLEOSIDE ANALOGUE, AND METHOD FOR PRODUCING SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-04-22 EP claimed
US-8957201-B2 Oligonucleotide analogues and methods utilizing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-02-17 US claimed
US-20110009471-A1 Oligonucleotide analogues and methods utilizing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-01-13 US claimed
US-7816333-B2 Oligonucleotide analogues and methods utilizing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2010-10-19 US claimed
US-20090149404-A1 Oligonucleotide analogues and methods utilizing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-06-11 US claimed
US-7335765-B2 Nucleoside and oligonucleotide analogues DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-02-26 US claimed
US-7314923-B2 Nucleoside and oligonucleotide analogues DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-01-01 US claimed
EP-1152009-B1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES SANKYO CO (JP) 2005-01-26 EP claimed
US-20030207841-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY LIMITED (JP) 2003-11-06 US claimed
US-20020147332-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY, LIMITED (JP) 2002-10-10 US claimed
EP-1152009-A1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES Sankyo Company, Limited (JP) 2001-11-07 EP claimed
US-20230348522-A1 METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-11-02 US disclosed
EP-1201678-A1 NOVEL BICYCLONUCLEOSIDE ANALOGUES Sankyo Company, Limited (JP) 2002-05-02 EP disclosed
EP-1152009-A1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES Sankyo Company, Limited (JP) 2001-11-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150152132-A1 Intermediate for Production of Nucleoside Analog and Method for Producing the Same RNGTT, NSUN2, RNMT ADORA1 874/4885ALDH1A1 2978/4885LMNA 887/4885
US-20160068561-A9 Intermediate for Production of Nucleoside Analog and Method for Producing the Same RNGTT, NSUN2, RNMT ADORA1 874/4885ALDH1A1 2978/4885LMNA 887/4885
US-20110009471-A1 Oligonucleotide analogues and methods utilizing the same NSUN2, RNGTT, DUT ADORA1 198/4885ALDH1A1 1693/4885LMNA 764/4885
US-20020147332-A1 Novel nucleoside and oligonucleotide analogues RNGTT, NSUN2, MTAP ADORA1 35/4885ALDH1A1 1208/4885LMNA 2615/4885
US-20090149404-A1 Oligonucleotide analogues and methods utilizing the same NSUN2, RNGTT, DUT ADORA1 198/4885ALDH1A1 1693/4885LMNA 764/4885
US-20030207841-A1 Novel nucleoside and oligonucleotide analogues RNGTT, NSUN2, MTAP ADORA1 35/4885ALDH1A1 1208/4885LMNA 2615/4885
US-20230348522-A1 METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE PFAS, ENPP1, NAAA ADORA1 2740/4885ALDH1A1 2704/4885LMNA 1660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.