Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | PTPRA | P18433 | 1/20 | 0.64 |
| ▸ | PTPRB | P23467 | 1/20 | 0.64 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.64 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.60 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.58 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.58 |
| ▸ | MPL | P40238 | 4/20 | 0.56 |
| ▸ | CTRC | Q99895 | 2/20 | 0.56 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11653446 | 0.87 | CTRB1 (0.56) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL11650539 | 0.87 | CTRB1 (0.56) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL3486861 | 0.84 | CTRB1 (0.76) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL11650543 | 0.84 | CYP1A2 (0.55) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL16689771 | 0.84 | CYP1A2 (0.84) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL11883462 | 0.84 | CYP1A2 (0.58) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL943732 | 0.83 | MPL (0.76) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL11883457 | 0.83 | THRB (0.59) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL3771521 | 0.82 | MPL (0.71) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL3771513 | 0.82 | MPL (0.71) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111296492-A | Diatomite-tea geometrid nuclear polyhedrosis virus composition and application thereof | 广西益才农业发展有限公司 | 2020-06-19 | — | — | CN | claimed |
| US-6639043-B1 | Producing polycarbonates having reduced levels of Fries rearrangement product | GENERAL ELECTRIC COMPANY | 2003-10-28 | — | — | US | claimed |
| CN-108473484-B | Compounds useful as TRPM8 modulators | 弗门尼舍公司 | 2021-06-29 | — | — | CN | disclosed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| CN-111296492-A | Diatomite-tea geometrid nuclear polyhedrosis virus composition and application thereof | 广西益才农业发展有限公司 | 2020-06-19 | — | — | CN | disclosed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356356-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | SENOMYX INC (US) | 2016-12-29 | — | — | US | disclosed |
| CN-101519537-A | Asymmetric azo complex dyes and process for their preparation | ABLE ADVANCED CHEMICALS CO LTD | 2009-09-02 | — | — | CN | disclosed |
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | AMBION, INC (US) | 2007-02-08 | — | — | US | disclosed |
| WO-2004076640-A2 | SMALL-MOLECULE INHIBITORS OF ANGIOGENIN AND RNASES AND IN VIVO AND IN VITRO METHODS OF USING SAME | AMBION, INC. (US) | 2004-09-10 | — | — | WO | disclosed |
| US-6639043-B1 | Producing polycarbonates having reduced levels of Fries rearrangement product | GENERAL ELECTRIC COMPANY | 2003-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032418-A1 | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same | RNASE1, RNASEH1, RNASEL | CYP1A2 4375/4885HIF1A 1080/4885CYP2C9 4801/4885 |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | TAS2R5, TAS1R1, TAS2R1 | CYP1A2 2167/4885HIF1A 1617/4885CYP2C9 1295/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | CYP1A2 4582/4885HIF1A 2571/4885CYP2C9 4437/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CYP1A2 4547/4885HIF1A 3487/4885CYP2C9 4487/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CYP1A2 4547/4885HIF1A 3487/4885CYP2C9 4487/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | CYP1A2 1422/4885HIF1A 2623/4885CYP2C9 309/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | CYP1A2 4547/4885HIF1A 3487/4885CYP2C9 4487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.