Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.57 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.57 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.57 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.57 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.57 |
| ▸ | P2RY6 known ✓ | Q15077 | 1/20 | 0.57 |
| ▸ | P2RY11 | Q96G91 | 9/20 | 0.79 |
| ▸ | RECQL | P46063 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.79 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.79 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | PKM | P14618 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 3/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.79 |
| ▸ | APEX1 | P27695 | 3/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11474334 | 0.89 | P2RY11 (0.76) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| Suramin SCHEMBL414636 | 0.88 | RECQL (1.00) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL29438489 | 0.86 | P2RY11 (0.75) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL11406414 | 0.86 | P2RY11 (0.78) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL17903265 | 0.85 | P2RY11 (0.78) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL5501853 | 0.84 | P2RY11 (0.77) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL11758251 | 0.81 | SIRT2 (0.64) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL29438482 | 0.80 | P2RY11 (0.74) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL11407249 | 0.80 | P2RY11 (0.74) | P2RY11RECQLKMT2AHSD17B10TDP1 | |
| SCHEMBL30205447 | 0.80 | HPSE (0.62) | P2RY11RECQLKMT2AHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240009152-A1 | METHODS OF MANUFACTURE OF SURAMIN | PERFECT DAYLIGHT LIMITED (MC) | 2024-01-11 | — | — | US | disclosed |
| EP-4188356-A1 | METHODS OF MANUFACTURE OF SURAMIN | Perfect Daylight Limited (MC) | 2023-06-07 | — | — | EP | disclosed |
| WO-2022026627-A1 | METHODS OF MANUFACTURE OF SURAMIN | PERFECT DAYLIGHT LIMITED (US) | 2022-02-03 | — | — | WO | disclosed |
| EP-1237853-B1 | A PROCESS FOR REMOVING TRACE SOLVENT FROM A MATERIAL | PFIZER SCIENCE & TECH LTD (IE) | 2007-03-28 | — | — | EP | disclosed |
| US-6684526-B2 | Process for removing trace solvent from a material | PFIZER SCIENCE AND TECHNOLOGY IRELAND, LIMITED (IE) | 2004-02-03 | — | — | US | disclosed |
| US-20020152629-A1 | Process for removing trace solvent from a material | PFIZER SCIENCE AND TECHNOLOGY IRELAND LIMITED (IE) | 2002-10-24 | — | — | US | disclosed |
| EP-1237853-A1 | A PROCESS FOR REMOVING TRACE SOLVENT FROM A MATERIAL | Warner Lambert Research and Development Ireland Limited (IE) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044173-A1 | A PROCESS FOR REMOVING TRACE SOLVENT FROM A MATERIAL | WARNER LAMBERT RESEARCH AND DEVELOPMENT IRELAND LIMITED (IE) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240009152-A1 | METHODS OF MANUFACTURE OF SURAMIN | SRM, SMS, NUDT1 | ADORA3 632/4885GABRA1 2977/4885P2RY2 527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.