Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5535948 | 0.89 | CCR2 (0.40) | THRBITGB3ITGA2BLMNASIGMAR1 | |
| SCHEMBL5530623 | 0.85 | SIGMAR1 (0.45) | THRBITGB3ITGA2BSIGMAR1 | |
| SCHEMBL5535143 | 0.85 | ITGB3 (0.37) | ITGB3ITGA2BLMNASIGMAR1MAPT | |
| SCHEMBL7387348 | 0.81 | MAPT (0.49) | LMNAHTTSIGMAR1MAPT | |
| SCHEMBL5530617 | 0.80 | SIGMAR1 (0.45) | THRBITGB3ITGA2BSIGMAR1 | |
| SCHEMBL7389203 | 0.79 | MAPT (0.47) | LMNAMAPT | |
| SCHEMBL7392101 | 0.78 | SIGMAR1 (0.46) | ITGB3ITGA2BSIGMAR1MAPT | |
| SCHEMBL7386854 | 0.78 | DGAT1 (0.42) | ITGB3ITGA2BLMNASIGMAR1MAPT | |
| SCHEMBL7473955 | 0.77 | MGLL (0.53) | ITGB3ITGA2BSIGMAR1 | |
| SCHEMBL7387950 | 0.77 | THRB (0.45) | THRBITGB3ITGA2BHTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416931-B1 | INHIBITORS OF POLYQ-AGGREGATION | MAX PLANCK GESELLSCHAFT (DE) | 2007-06-13 | — | — | EP | claimed |