Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782578 | 0.78 | — | — | |
| Acrylic Acid SCHEMBL5705251 | 0.78 | — | — | |
| SCHEMBL1279982 | 0.74 | — | — | |
| SCHEMBL1561975 | 0.72 | TSHR (0.44) | — | |
| SCHEMBL1561700 | 0.72 | TGFBR1 (0.44) | — | |
| SCHEMBL7749797 | 0.71 | — | — | |
| Potassium Ion SCHEMBL3656408 | 0.69 | TGFBR1 (0.44) | — | |
| Potassium Ion SCHEMBL3660409 | 0.69 | TSHR (0.44) | — | |
| Lithium Ion SCHEMBL6898224 | 0.69 | TSHR (0.44) | — | |
| Acrylamide SCHEMBL3827026 | 0.68 | TSHR (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7172875-B2 | Identifying inhibitors of intracellular protein fibrillization | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-02-06 | — | — | US | disclosed |
| EP-1115663-B1 | METHOD OF DEWATERING DIFFICULT SLUDGES | NALCO CHEMICAL CO (US) | 2006-09-20 | — | — | EP | disclosed |
| US-20050153384-A1 | Identifying inhibitors of intracellular protein fibrillization | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-07-14 | — | — | US | disclosed |
| WO-2004073651-A2 | IDENTIFYING INHIBITORS OF INTRACELLULAR PROTEIN FIBRILLIZATION | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2004-09-02 | — | — | WO | disclosed |
| EP-1115663-A4 | METHOD OF DEWATERING DIFFICULT SLUDGES | NALCO CHEMICAL CO (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-1115663-A1 | METHOD OF DEWATERING DIFFICULT SLUDGES | NALCO CHEMICAL COMPANY (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6083404-A | MIXING WITH AN COAGULANT AND FLOCCULANT | NALCO CHEMICAL COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| WO-2000017112-A1 | METHOD OF DEWATERING DIFFICULT SLUDGES | NALCO CHEMICAL COMPANY (US) | 2000-03-30 | — | — | WO | disclosed |