SCHEMBL5645669

SCHEMBL5645669

C[Si](C)(C)C#Cc1ccc(S(N)(=O)=O)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 13/20 0.61
CA12 O43570 12/20 0.61
CA1 P00915 12/20 0.61
CA9 Q16790 12/20 0.61
CA4 P22748 3/20 0.52
CA14 Q9ULX7 2/20 0.52
CA5A P35218 3/20 0.47
CA5B Q9Y2D0 3/20 0.47
CA6 P23280 2/20 0.47
CA7 P43166 2/20 0.47
CA3 P07451 1/20 0.47
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
ALOX5 P09917 1/20 0.46
PTPN6 P29350 1/20 0.45
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
CA13 Q8N1Q1 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
AGO2 Q9UKV8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL710011 0.82 LOX (0.46)
SCHEMBL22558460 0.81 LMNA (0.43) CA2CA12CA1CA9TSHR
SCHEMBL2262111 0.79 CA1 (0.65) CA2CA12CA1CA9CA4
SCHEMBL1306384 0.78 GABRA1 (0.38) TSHR
SCHEMBL18946201 0.78 LMNA (0.47) CA2CA12CA1CA9TSHR
SCHEMBL5867219 0.78 CA2 (0.68) CA2CA12CA1CA9CA4
SCHEMBL28553405 0.77 CA2 (0.56) CA2CA1CA9
SCHEMBL1306505 0.76 APP (0.41)
SCHEMBL22243575 0.74 CA12 (0.63) CA2CA12CA1CA9CA4
SCHEMBL20610141 0.74 ALDH1A1 (0.49) CA2CA12CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893934-B1 INSULIN CONJUGATES SANOFI SA (FR) 2025-09-10 EP disclosed
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. 2025-08-07 US disclosed
US-20250206798-A1 INSULIN CONJUGATES SANOFI SA (FR) 2025-06-26 US disclosed
EP-4504179-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF Corbus Pharmaceuticals, Inc. (US) 2025-02-12 EP disclosed
CN-119325378-A Cannabinoid receptor 1 antagonists/inverse agonists and uses thereof 柯巴斯医药有限公司 2025-01-17 CN disclosed
US-12195510-B2 Insulin conjugates SANOFI (FR) 2025-01-14 US disclosed
WO-2023196556-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. (US) 2023-10-12 WO disclosed
WO-2023196556-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. (US) 2023-10-12 WO disclosed
CN-110997651-B Novel tetrazole compounds and their use in the treatment of tuberculosis 葛兰素史密斯克莱知识产权发展有限公司 2023-01-03 CN disclosed
US-20220048968-A1 INSULIN CONJUGATES SANOFI (FR) 2022-02-17 US disclosed
WO-2019034729-A1 NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-02-21 WO disclosed
US-20150051242-A1 RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME ZHEJIANG ZYLOX MEDICAL DEVICE CO., LTD. (CN) 2015-02-19 US disclosed
US-20150051242-A1 RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME ZHEJIANG ZYLOX MEDICAL DEVICE CO., LTD. (CN) 2015-02-19 US disclosed
US-7259266-B2 Benzopyran compounds useful for treating inflammatory conditions PHARMACIA CORPORATION (US) 2007-08-21 US disclosed
EP-1631562-A1 CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS Pharmacia Corporation (US) 2006-03-08 EP disclosed
EP-1615905-A2 BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS Pharmacia Corporation (US) 2006-01-18 EP disclosed
US-20050148627-A1 Benzopyran compounds for use in the treatment and prevention of inflammation related conditions CARTER JEFFERY (US) 2005-07-07 US disclosed
US-20050148777-A1 Benzopyran compounds useful for treating inflammatory conditions CARTER JEFFERY (US) 2005-07-07 US disclosed
WO-2004087687-A1 CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS PHARMACIA CORPORATION (US) 2004-10-14 WO disclosed
WO-2004087686-A2 BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS PHARMACIA CORPORATION (US) 2004-10-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148777-A1 Benzopyran compounds useful for treating inflammatory conditions PTGES2, PTGER2, PTGS2 CA2 2055/4885CA12 3875/4885CA1 4118/4885
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CNR1, CNR2, GPR119 CA2 4564/4885CA12 4522/4885CA1 4654/4885
US-20220048968-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R CA2 1521/4885CA12 453/4885CA1 1162/4885
US-12195510-B2 Insulin conjugates IAPP, INSR, IGF1R CA2 1521/4885CA12 453/4885CA1 1162/4885
US-20150051242-A1 RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME RICTOR, MTOR, RPTOR CA2 3528/4885CA12 3665/4885CA1 1298/4885
US-20250206798-A1 INSULIN CONJUGATES IAPP, INSR, IGF1R CA2 1521/4885CA12 453/4885CA1 1162/4885
US-20050148627-A1 Benzopyran compounds for use in the treatment and prevention of inflammation related conditions PTGES2, PTGER2, PTGES CA2 1814/4885CA12 3558/4885CA1 3613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.