Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | ATM | Q13315 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MYLK | Q15746 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | GMNN | O75496 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31033068 | 1.00 | KMT2A (0.77) | KMT2AATMCYP3A4NFKB1CYP1A2 | |
| SCHEMBL19856464 | 0.99 | KMT2A (0.75) | KMT2AATMCYP3A4NFKB1CYP1A2 | |
| SCHEMBL18138090 | 0.99 | KMT2A (0.75) | KMT2AATMCYP3A4NFKB1CYP1A2 | |
| SCHEMBL29437927 | 0.90 | KMT2A (0.88) | KMT2AATMCYP1A2MEN1CYP2C19 | |
| SCHEMBL25531 | 0.90 | KMT2A (0.88) | KMT2AATMCYP1A2MEN1CYP2C19 | |
| SCHEMBL15934204 | 0.84 | KMT2A (0.79) | KMT2AATMCYP1A2MEN1LMNA | |
| SCHEMBL14256516 | 0.82 | KMT2A (0.75) | KMT2AATMCYP1A2MEN1CYP2C19 | |
| SCHEMBL12604576 | 0.82 | KMT2A (0.75) | KMT2AATMCYP1A2MEN1CYP2C19 | |
| SCHEMBL29678142 | 0.82 | KMT2A (0.70) | KMT2AATMCYP1A2CYP2C19HIF1A | |
| SCHEMBL32677285 | 0.81 | KMT2A (0.74) | KMT2AATMCYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112697897-B | Derivatization reagent and application thereof | 中国药科大学 | 2022-09-23 | — | — | CN | disclosed |
| CN-112697897-A | Derivatization reagent and application thereof | 中国药科大学 | 2021-04-23 | — | — | CN | disclosed |
| US-10894777-B2 | TG2 inhibitor piperazine compounds and uses thereof | UNIVERSITY OF OTTAWA (CA) | 2021-01-19 | — | — | US | disclosed |
| EP-3442533-A1 | TG2 INHIBITOR COMPOUNDS AND USES THEREOF | University Of Ottawa (CA) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017179018-A1 | TG2 INHIBITOR COMPOUNDS AND USES THEREOF | UNIVERSITY OF OTTAWA (CA) | 2017-10-19 | — | — | WO | disclosed |
| WO-2017179018-A1 | TG2 INHIBITOR COMPOUNDS AND USES THEREOF | UNIVERSITY OF OTTAWA (CA) | 2017-10-19 | — | — | WO | disclosed |
| US-9173946-B2 | Bifunctional hydroxy-bisphosphonic acid derivatives | ATLANTHERA (FR) | 2015-11-03 | — | — | US | disclosed |
| US-9173946-B2 | Bifunctional hydroxy-bisphosphonic acid derivatives | ATLANTHERA (FR) | 2015-11-03 | — | — | US | disclosed |
| US-9040513-B2 | Process for preparing platinum-carbene complexes | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-05-26 | — | — | US | disclosed |
| US-20140086843-A1 | BIFUNCTIONAL HYDROXY-BISPHOSPHONIC ACID DERIVATIVES | ATLANTHERA (FR) | 2014-03-27 | — | — | US | disclosed |
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| US-20030068275-A1 | Coordination complexes for detecting analytes, and methods of making and using the same | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2003-04-10 | — | — | US | disclosed |
| EP-0836597-A1 | N-SUBSTITUTED PIPERAZINE NONOATES | THE UNITED STATES OF AMERICA (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5721365-A | N-substituted piperazine NONOates | HEALTH AND HUMAN SERVICES, DEPARTMENT OF, UNITED STATES, AS REPRESENTED BY ITS SECRETARY | 1998-02-24 | — | — | US | disclosed |
| WO-1996040665-A1 | N-SUBSTITUTED PIPERAZINE NONOATES | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140086843-A1 | BIFUNCTIONAL HYDROXY-BISPHOSPHONIC ACID DERIVATIVES | BPGM, PHPT1, PTH1R | KMT2A 4053/4885ATM 4849/4885CYP3A4 3864/4885 |
| US-20030068275-A1 | Coordination complexes for detecting analytes, and methods of making and using the same | SPR, CACYBP, CA13 | KMT2A 3832/4885ATM 3264/4885CYP3A4 483/4885 |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | LIPE, PNLIP, LPL | KMT2A 4150/4885ATM 1011/4885CYP3A4 2474/4885 |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | LIPE, PNLIP, LPL | KMT2A 4322/4885ATM 1103/4885CYP3A4 2867/4885 |
| US-10894777-B2 | TG2 inhibitor piperazine compounds and uses thereof | TGM2, TGM1, TGM3 | KMT2A 497/4885ATM 3030/4885CYP3A4 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.