Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL1168962 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7941570 | 0.97 | ALDH1A1 (0.47) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL20954078 | 0.94 | ALDH1A1 (0.47) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL20954075 | 0.94 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL9775691 | 0.94 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL5907607 | 0.92 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL11062591 | 0.91 | ALDH1A1 (0.50) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7941579 | 0.86 | ALDH1A1 (0.43) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7567172 | 0.86 | ALDH1A1 (0.43) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL8412858 | 0.86 | LMNA (0.53) | ALDH1A1CA4CA1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006112533-A1 | WATER-CONTAINING GEL FORM AND PRODUCTION METHOD THEREOF | SHOWA DENKO K.K. (JP) | 2006-10-26 | — | — | WO | disclosed |
| US-20060079640-A1 | Adhesive composition for dermal patch and production process thereof | SHOWA DENKO K.K. (JP) | 2006-04-13 | — | — | US | disclosed |
| EP-1558225-A1 | ADHESIVE COMPOSITION FOR DERMAL PATCH AND PRODUCTION PROCESS THEREOF | Showa Denko K.K. (JP) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004039358-A1 | ADHESIVE COMPOSITION FOR DERMAL PATCH AND PRODUCTION PROCESS THEREOF | SHOWA DENKO K.K. (JP) | 2004-05-13 | — | — | WO | disclosed |
| US-4797223-A | ANIONIC, CATIONIC OR NONIONIC SURFACTANTS | ROHM AND HAAS COMPANY (US) | 1989-01-10 | — | — | US | disclosed |