Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.40 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL29061129 | 0.95 | ALDH1A1 (0.45) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL29061142 | 0.95 | ALDH1A1 (0.43) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL28861161 | 0.95 | ALDH1A1 (0.43) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL7941579 | 0.95 | ALDH1A1 (0.43) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL28087404 | 0.91 | ALDH1A1 (0.36) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL1168962 | 0.86 | ALDH1A1 (0.45) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL5712918 | 0.86 | ALDH1A1 (0.45) | ALDH1A1CA1TSHRTP53LMNA | |
| Acrylic Acid SCHEMBL3273158 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL7941570 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CA1TSHRTP53LMNA | |
| Methacrylic Acid SCHEMBL11359770 | 0.83 | CA1 (0.50) | ALDH1A1CA1LMNACA4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103304734-A | Preparation method of thixotropic thickening agent for ternary amphoteric neutral ink | UNIV GUANGZHOU | 2013-09-18 | — | — | CN | claimed |
| CN-101955566-A | Ternary zwitterionic hair holding polymer for hair and preparation method thereof | UNIV GUANGZHOU | 2011-01-26 | — | — | CN | claimed |
| EP-0161763-A1 | Water swellable copolymers having high water absorbency | Pony Industries Incorporated (US) | 1985-11-21 | — | — | EP | claimed |
| CN-107793526-B | PH-sensitive oil-water double-absorption resin, preparation method and application thereof in well cementation | 中国石油大学(华东) | 2020-05-12 | — | — | CN | disclosed |
| CN-103304734-B | A kind of preparation method of ternary both sexes Neutral writing ink thixotropic thickner | GUANGZHOU UNIVERSITY (CN) | 2015-10-28 | — | — | CN | disclosed |
| CN-103304734-A | Preparation method of thixotropic thickening agent for ternary amphoteric neutral ink | UNIV GUANGZHOU | 2013-09-18 | — | — | CN | disclosed |
| CN-101955566-A | Ternary zwitterionic hair holding polymer for hair and preparation method thereof | UNIV GUANGZHOU | 2011-01-26 | — | — | CN | disclosed |
| EP-1236748-A1 | Polymer flocculents and preparation thereof | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2002-09-04 | — | — | EP | disclosed |
| US-5969005-A | INK COMPRISING WATER, COLORING MATERIAL, WATER SOLUBLE ORGANIC SOLVENT, POLYMER CONTAINING CARBOXYL GROUP, WATER SOLUBLE ORGANIC COMPOUND VAPORIZABLE ON HEATING, COMPOUND HAVING ETHER GROUP AND HYDROXYL GROUP | FUJI XEROX CO., LTD (JP) | 1999-10-19 | — | — | US | disclosed |