Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 3/20 | 0.45 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL5712918 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7941570 | 0.97 | ALDH1A1 (0.47) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL20954078 | 0.94 | ALDH1A1 (0.47) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL20954075 | 0.94 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL9775691 | 0.94 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL5907607 | 0.92 | ALDH1A1 (0.45) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL11062591 | 0.91 | ALDH1A1 (0.50) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7941579 | 0.86 | ALDH1A1 (0.43) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL7567172 | 0.86 | ALDH1A1 (0.43) | ALDH1A1CA4CA1TSHRTP53 | |
| Methacrylic Acid SCHEMBL8412858 | 0.86 | LMNA (0.53) | ALDH1A1CA4CA1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7883767-B2 | two or more consecutive pore-coating layers to a porous support to achieve very hydrophilic composite materials; 1st gel polymer layer having both hydrophobic and hydrophilic properties, second polymer layer which durably coats the surface of the first polymer layer being more hydrophilic than first | MCMASTER UNIVERSITY (CA) | 2011-02-08 | — | — | US | claimed |
| CN-106397640-B | water-soluble antibacterial acrylic polymer silver salt | 王式禹 | 2019-01-18 | — | — | CN | disclosed |
| WO-2017066540-A1 | NANOCRYSTALLINE CELLULOSE AND POLYMER-GRAFTED NANOCRYSTALLINE CELLULOSE AS RHEOLOGY MODIFYING AGENTS FOR MAGNESIUM OXIDE AND LIME SLURRIES | ECOLAB USA INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| CN-104130751-B | Bio-based alcohol aircraft deicing anti-freeze fluid and preparation method thereof | 中国民用航空总局第二研究所 | 2016-08-17 | — | — | CN | disclosed |
| CN-103154006-B | Process for preparing acryloxysilanes | 道康宁公司 | 2016-07-06 | — | — | CN | disclosed |
| EP-1291334-B1 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | TAKEMOTO OIL & FAT CO LTD (JP) | 2013-10-23 | — | — | EP | disclosed |
| CN-1239528-C | Anti-coagulation agent and anti-coagulation method for blast furnace water granulated slag or particle size adjustment thereof | STEEL PIPE & MINING INDUSTRY C (JP) | 2006-02-01 | — | — | CN | disclosed |
| US-6936673-B2 | Anti-bonding methods for blast furnace slag or its grading adjusted slag | TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) | 2005-08-30 | — | — | US | disclosed |
| US-20050065306-A1 | Anti-bonding methods for blast furnace slag or its grading adjusted slag | KOKAN MINING CO., LTD., A CORPORATION OF JAPAN | 2005-03-24 | — | — | US | disclosed |
| US-6835758-B2 | Water compatible energy curable compositions containing malemide derivatives | SUN CHEMICAL CORPORATION | 2004-12-28 | — | — | US | disclosed |
| US-20040110859-A1 | Water compatible energy curable compositions containing malemide derivatives | SUN CHEMICAL CORPORATION | 2004-06-10 | — | — | US | disclosed |
| US-20030110896-A1 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | KOKAN MINING CO., LTD. | 2003-06-19 | — | — | US | disclosed |
| CN-1407118-A | Anti-coagulation agent and anti-coagulation method for blast furnace water granulated slag or particle size adjustment thereof | STEEL PIPE & MINING INDUSTRY C (JP) | 2003-04-02 | — | — | CN | disclosed |
| EP-1291334-A2 | Anti-bonding agents and methods for blast furnace slag or its grading adjusted slag | Takemoto Yushi Kabushiki Kaisha (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-0303747-B1 | Acrylic polymer and cement composition containing it | GRACE W R & CO (US) | 1994-02-16 | — | — | EP | disclosed |
| US-4968734-A | COPOLYMER OF METH!ACRYLIC ACID AND HYDROXYALKYL (METH)ACRYLATE AS PLASTICIZER | W. R. GRACE & CO.-CONN. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0303747-A2 | Acrylic polymer and cement composition containing it | W.R. Grace & Co.-Conn. (US) | 1989-02-22 | — | — | EP | disclosed |