Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 10/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LTA | P01374 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602304 | 0.92 | RAD51 (0.58) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL31389378 | 0.92 | RAD51 (0.58) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL6397268 | 0.92 | RAD51 (0.58) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL29692691 | 0.92 | RAD51 (0.58) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| Lithium Ion SCHEMBL8492595 | 0.88 | RAD51 (0.58) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL5749384 | 0.88 | RAD51 (0.51) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL3936737 | 0.84 | RAD51 (0.50) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL6345692 | 0.84 | RAD51 (0.50) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL31427086 | 0.84 | RAD51 (0.50) | RAD51KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL29404354 | 0.84 | RAD51 (0.50) | RAD51KDM4EALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170290-B9 | Compounds having ultra-violet absorption properties | CIBA SC HOLDING AG (CH) | 2006-09-13 | — | — | EP | disclosed |
| EP-1170290-B1 | Compounds having ultra-violet absorption properties | CIBA SC HOLDING AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| EP-1170290-A2 | Compounds having ultra-violet absorption properties | Ciba SC Holding AG (CH) | 2002-01-09 | — | — | EP | disclosed |
| US-6045586-A | IMPROVING THE SUN PROTECTION FACTOR (SPF) OF TEXTILE FIBRE BY TREATING WITH 1,3,5-TRIAZINE DERIVATIVES OF GIVEN FORMULA | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |
| US-5741905-A | Triazine ultraviolet absorbers useful for improving the sun protection factor of textiles | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-04-21 | — | — | US | disclosed |
| EP-0693483-A1 | Compounds having ultra-violet absorption properties | CIBA-GEIGY AG (CH) | 1996-01-24 | — | — | EP | disclosed |