SCHEMBL578359

SCHEMBL578359

CCCCC(F)C([O])(F)F

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPT P10636 1/20 0.35
DNM1 Q05193 2/20 0.35
TSHR P16473 2/20 0.34
CYP3A4 P08684 2/20 0.34
FDPS P14324 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CA2 P00918 5/20 0.34
CA1 P00915 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
FAAH O00519 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21313332 0.93 MAPT (0.43) MAPTFDPSCA1FAAH
SCHEMBL578777 0.84
SCHEMBL45380 0.79 DNM1 (0.38) ALDH1A1TDP1MAPTDNM1TSHR
SCHEMBL831154 0.76 MAPT (0.38) MAPTDNM1TSHRFDPSSMN1; SMN2
SCHEMBL23825077 0.75 FDPS (0.36) ALDH1A1MAPTDNM1FDPSCA2
SCHEMBL22398662 0.75 DNM1 (0.35) ALDH1A1TDP1MAPTDNM1TSHR
SCHEMBL833676 0.75 DNM1 (0.35) ALDH1A1TDP1MAPTDNM1TSHR
SCHEMBL23825068 0.75 FDPS (0.36) ALDH1A1MAPTDNM1FDPSCA2
SCHEMBL45136 0.75 DNM1 (0.35) ALDH1A1TDP1MAPTDNM1TSHR
SCHEMBL28292487 0.75 DNM1 (0.35) ALDH1A1TDP1MAPTDNM1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3992177-B1 DERIVATIVE COMPOUND INTRODUCING BIPHENYL GROUP INTO NOVEL AMINOALKANOIC ACID AND ANTIFUNGAL PHARMACEUTICAL COMPOSITION COMPRISING SAME AMTIXBIO CO LTD (KR) 2024-05-08 EP disclosed
EP-4349329-A1 BENZYLOXY-BENZYLAMINYL AMINO ACID DERIVATIVE FOR ADJUSTING TSLP/TSLPR SIGNAL TRANSMISSION Amtixbio Co., Ltd. (KR) 2024-04-10 EP disclosed
US-20230067422-A1 AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AND USE OF THE SAME AMTIXBIO CO., LTD. (KR) 2023-03-02 US disclosed
US-20230056812-A1 METHOD FOR PREPARING AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AMTIXBIO CO., LTD. (KR) 2023-02-23 US disclosed
US-20230053855-A1 PHARMACEUTICAL COMPOSITION COMPRISING AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AMTIXBIO CO., LTD. (KR) 2023-02-23 US disclosed
WO-2022255801-A1 BENZYLOXY-BENZYLAMINYL AMINO ACID DERIVATIVE FOR ADJUSTING TSLP/TSLPR SIGNAL TRANSMISSION (주)앰틱스바이오 2022-12-08 WO disclosed
US-20220144755-A1 NOVEL AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AND ANTIFUNGAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AMTIXBIO CO., LTD. (KR) 2022-05-12 US disclosed
EP-3992177-A1 DERIVATIVE COMPOUND INTRODUCING BIPHENYL GROUP INTO NOVEL AMINOALKANOIC ACID AND ANTIFUNGAL PHARMACEUTICAL COMPOSITION COMPRISING SAME Amtixbio Co., Ltd. (KR) 2022-05-04 EP disclosed
CN-114051496-A Derivative compound for introducing biphenyl group into novel amino alkanoic acid and antifungal pharmaceutical composition comprising same 阿米蒂比奥有限公司 2022-02-15 CN disclosed
US-20200199065-A1 FUNCTIONAL DERIVATIVE COMPOUNDS OF ALANINE AND PROLINE AMINO ACIDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AMTIXBIO CO., LTD. (KR) 2020-06-25 US disclosed
US-20120220593-A1 Substituted Acrylamide Derivative and Pharmaceutical Composition Comprising the Same DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-08-30 US disclosed
US-8143446-B2 Substituted acrylamide derivative and pharmaceutical composition comprising the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-03-27 US disclosed
US-20120040936-A1 CYCLIC COMPOUND HAVING SUBSTITUTED PHENYL GROUP DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-02-16 US disclosed
EP-2418203-A1 CYCLIC COMPOUND HAVING SUBSTITUTED PHENYL GROUP Daiichi Sankyo Company, Limited (JP) 2012-02-15 EP disclosed
US-20110269746-A1 CYCLIC COMPOUND HAVING HETERO ATOM DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-11-03 US disclosed
EP-2380878-A1 CYCLIC COMPOUND HAVING HETERO ATOM Daiichi Sankyo Company, Limited (JP) 2011-10-26 EP disclosed
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-11-26 US disclosed
US-20090118199-A1 SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DAIICHI SANKYO COMPANY , LIMITED (JP) 2009-05-07 US disclosed
EP-1908466-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Daiichi Sankyo Company, Limited (JP) 2008-04-09 EP disclosed
EP-1880720-A1 SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Daiichi Sankyo Company, Limited (JP) 2008-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120040936-A1 CYCLIC COMPOUND HAVING SUBSTITUTED PHENYL GROUP BMP2, BMP4, BMP6 ALDH1A1 2092/4885TDP1 4614/4885MAPT 4571/4885
US-20090292024-A1 SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PTMS, C1S, ACP3 ALDH1A1 298/4885TDP1 3856/4885MAPT 3124/4885
US-20230053855-A1 PHARMACEUTICAL COMPOSITION COMPRISING AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AHR, AADAC, GABBR1 ALDH1A1 1001/4885TDP1 3446/4885MAPT 1422/4885
US-20110269746-A1 CYCLIC COMPOUND HAVING HETERO ATOM BMP2, BMP4, BMP1 ALDH1A1 3358/4885TDP1 4811/4885MAPT 4445/4885
US-20090118199-A1 SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME ACR, NAT1, C1S ALDH1A1 75/4885TDP1 1470/4885MAPT 2207/4885
US-20220144755-A1 NOVEL AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AND ANTIFUNGAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AADAC, GABBR1, AHR ALDH1A1 1163/4885TDP1 3777/4885MAPT 2190/4885
US-20230067422-A1 AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AND USE OF THE SAME GABBR1, AADAC, GABBR2 ALDH1A1 628/4885TDP1 3705/4885MAPT 2615/4885
US-20230056812-A1 METHOD FOR PREPARING AMINOALKANOIC ACID DERIVATIVE CONTAINING BIPHENYL GROUP AKR7A2, CYP51A1, APEH ALDH1A1 613/4885TDP1 3497/4885MAPT 2911/4885
US-20200199065-A1 FUNCTIONAL DERIVATIVE COMPOUNDS OF ALANINE AND PROLINE AMINO ACIDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME PEPD, BCAT1, ANPEP ALDH1A1 1968/4885TDP1 2289/4885MAPT 1844/4885
US-20120220593-A1 Substituted Acrylamide Derivative and Pharmaceutical Composition Comprising the Same ACR, NAT1, C1S ALDH1A1 75/4885TDP1 1470/4885MAPT 2207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.