Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757552 | 0.86 | LMNA (0.60) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL21715039 | 0.84 | LMNA (0.58) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL31483318 | 0.83 | ALDH1A1 (0.60) | LMNAHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL917955 | 0.83 | ALDH1A1 (0.60) | LMNAHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28221986 | 0.82 | POLB (0.48) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL25252086 | 0.81 | POLB (0.62) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL21715126 | 0.81 | PLA2G1B (0.56) | LMNAPOLBHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25252085 | 0.81 | POLB (0.62) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL312623 | 0.81 | LMNA (0.55) | LMNAPOLBHTTSMN1; SMN2ALOX15 | |
| SCHEMBL28575796 | 0.81 | TP53 (0.52) | LMNAPOLBHTTSMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696617-B2 | Method for alcoholysis of amide | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2020-06-30 | — | — | US | disclosed |
| US-20200055807-A1 | METHOD FOR ALCOHOLYSIS OF AMIDE | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2020-02-20 | — | — | US | disclosed |
| CN-107417594-A | A kind of method of acid amides alcoholysis | 凯莱英医药集团（天津）股份有限公司 | 2017-12-01 | — | — | CN | disclosed |
| US-7005450-B2 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | PHARMACIA CORPORATION (US) | 2006-02-28 | — | — | US | disclosed |
| US-20050256199-A1 | 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | PHARMACIA CORPORATION | 2005-11-17 | — | — | US | disclosed |
| CN-1217922-C | 2-Amino-2-alkyl-4-hexenoic and hexynoic acid derivatives as nitric oxide synthase inhibitors | PHARMACIA CORP (US) | 2005-09-07 | — | — | CN | disclosed |
| US-20040192779-A1 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | DURLEY RICHARD C (US) | 2004-09-30 | — | — | US | disclosed |
| US-6756406-B2 | ANTIARTHRITIC AGENTS; RHEUMATIC DISEASES; OSTEOARTHRITIS; INHIBITION OF THE INDUCIBLE NITRIC OXIDE SYNTHASE - INDUCED AFTER ACTIVATION OF VASCULAR SMOOTH MUSCLE, MACROPHAGES, ENDOTHELIAL CELLS BY ENOTOXIN AND CYTOKINES | PHARMACIA CORPORATION | 2004-06-29 | — | — | US | disclosed |
| CN-1474804-A | 2-amino-2-alkyl-4-hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | — | 2004-02-11 | — | — | CN | disclosed |
| EP-1317416-A2 | 2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | Pharmacia Corporation (US) | 2003-06-11 | — | — | EP | disclosed |
| US-20020128510-A1 | 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | PHARMACIA CORPORATION | 2002-09-12 | — | — | US | disclosed |
| WO-2002022559-A2 | 2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | PHARMACIA CORPORATION (US) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192779-A1 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | ALOX12, ALOX5, ALOX15 | LMNA 3169/4885POLB 2582/4885HTT 2535/4885 |
| US-20020128510-A1 | 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | ALOX12, ALOX5, ALOX15 | LMNA 3169/4885POLB 2582/4885HTT 2535/4885 |
| US-20200055807-A1 | METHOD FOR ALCOHOLYSIS OF AMIDE | ADH1A, ADH5, ADH1C | LMNA 963/4885POLB 299/4885HTT 4723/4885 |
| US-20050256199-A1 | 2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors | ALOX12, ALOX5, ALOX15 | LMNA 3169/4885POLB 2582/4885HTT 2535/4885 |
| US-10696617-B2 | Method for alcoholysis of amide | ADH5, ADH1A, ADH1C | LMNA 1293/4885POLB 444/4885HTT 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.